báo cáo khoa học: "Down-regulation of TM4SF is associated wi

báo cáo khoa học: "Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma" ppt

... gastric carcinoma tissues, we investigated the expression of these three TM4SF members to determine whether they correlate with the invasiveness and metastatic ability of gastric carcinoma cells. Materials ... binding of integrins to their ligands or on integrin-mediated static cell adhe- sion to the extracellular matrix [35]. Instead, they regu- late post-ligand b...

Ngày tải lên : 09/08/2014, 01:24

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Báo cáo khoa học: " Higher initial tidal volumes associated with the subsequent development of acute lung injury in dose-response relationship" docx

... the consistency of the findings with those of other animal and human studies are reassuring. As noted in the accompanying editorial [5], it is surprising that 30% of subjects in this study ... address the issue of whether certain PEEP-based strategies can mediate the potential risks of low tidal volume ventilation. Recommendation Based on the results of...

Ngày tải lên : 12/08/2014, 23:20

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báo cáo khoa học: "Apple skin patterning is associated with differential expression of MYB10" ppsx

... diversity in the MYB10 coding region in ‘Hon- eycrisp’, with no evidence suggesting that the blushed/ striped phenomeno n is associated with modifications at the primary DNA sequence level within the ... upstream of the coding region is unknown. We did not find any evidence of transposable element sequences within the highly methylated promoter region of MYB10....

Ngày tải lên : 11/08/2014, 11:20

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báo cáo hóa học:" A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study" pdf

... 3 indicates the number of patients car- rying the haplotype consisting of the -173 C and the -794 CATT 7 allele. Accordingly, these patients display the -173 SNP C/C or G/C genotype in combination ... confirmed these findings. The relative risks for poor outcome of the two polymorphisms and combination of both were 1.6, 1.84 and 1.80. This effect size was in line w...

Ngày tải lên : 18/06/2014, 15:20

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Tài liệu Báo cáo khoa học: Mouse recombinant protein C variants with enhanced membrane afﬁnity and hyper-anticoagulant activity in mouse plasma pptx

... folded membrane-binding domain [9,10]. This Ca 2+ binding requires the presence of Gla residues. The Gla domains within the protein C family comprise 44 amino acids and contain between nine and 11 ... when the saturation binding levels of the protein C variants were compared, for any of the phospholipid mem- branes tested, implying a different mode of binding between the...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx

... over-expressing the interacting PDZ domains, the resulting response of OR2AG1 to odorant is modiﬁed in that the rapid decay of signal is impaired. We ﬁnally examined the effect of deletion of the components ... and discovered that up to 30% of receptors contain putative PDZ binding motifs in their C-termini, following the previ- ously outlined rules of binding...

Ngày tải lên : 18/02/2014, 13:20

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Tài liệu Báo cáo khoa học: Evidence for noncooperative metal binding to the a domain of human metallothionein ppt

... goal is to elucidate the metallation mechanisms of the individual domains, in the hope, initially, of simplifying the interpretation of the metallation details of the two-domain protein. The results ... investigated the metal-binding reactivity of the isolated a domain of human metallothionein isoform 1a, with speciﬁc emphasis on resolving the debate co...

Ngày tải lên : 19/02/2014, 00:20

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Báo cáo khoa học: Androgen receptor function is modulated by the tissue-speciﬁc AR45 variant ppt

... variant composed of a unique N-terminal extension linked to the DNA-binding domain (DBD), hinge region and ligand-binding domain (LBD) of the AR. The restricted expression pattern, the inhibitory ... activity, depending on the respective levels of each protein and of cofactors such as TIF2 and b-catenin. This study raises the possibility of a role of AR45 in modu...

Ngày tải lên : 07/03/2014, 16:20

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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot

... towards the understanding of the mechanisms of this disorder. This minireview summarizes the advances in CCM molecular genetics and the remaining gaps in this ﬁeld. In addition to the identiﬁcation ... detected in the six remaining lesions. Several hypotheses may be raised to explain this absence of mutation including the incomplete sensitiv- ity of this type...

Ngày tải lên : 15/03/2014, 10:20

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Báo cáo khoa học: Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway potx

... whether the SLe x level of InR on insulin-responsive cells in diabetic patients was changed. This may reveal the role of the sugar chains on InR in the pathogenesis of diabetes. In summary, the ... 1 mg % of leupeptin and pepstatin). After protein determination, cell lysate contain- ing 500 lg protein was incubated with 5 lg of one of the following antibodies (...

Ngày tải lên : 16/03/2014, 12:20

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