Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... signifi-cantly inhibited at nanomolar concentrations of RWJ 67657, and mRNA expression was also decreased, by nearly 50% at 10 nM. Inhibition of p38 MAPK activity leadsto reduced TNF-α mRNA expression ... biosynthesis. Nat Cell Biol 1999, 1:94-97.21. Bhattacharyya A, Pathak S, Datta S, Chattopadhyay S, Basu J,Kundu M: Mitogen-activated protein kinases and nuclear fac-tor-kappaB regulate Helicobacter pylori-mediated ... undercontrol of the p38 MAPK route. Inhibition of the p38 MAPKroute may inhibit production not only of TNF-α, but also of otherinflammatory mediators produced by macrophages, and indirectly of inflammatory...
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Báo cáo y học: " Evidence for natural antisense transcript-mediated inhibition of microRNA function" ppsx
... regulation to maintain a narrowwindow between essential and pathological expression of BACE1. Sequential cleavage of amyloid precursor protein by BACE-1 and γ-secretase represents a central event ... proposedactions of BACE1-AS, promoting target mRNA stability by duplex formation and inhibiting miRNA-induced mRNA decay and translational repression, serve to ele-vate BACE1 concentrations.Alzheimer's ... revealed by RACE and high-density tiling arrays. Genome Res 2005, 15:987-997.3. Gustincich S, Sandelin A, Plessy C, Katayama S, Simone R, Lazarevic D, Hayashizaki Y, Carninci P: The complexity...
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Báo cáo y học: " Strong functional patterns in the evolution of eukaryotic genomes revealed by the reconstruction of ancestral protein domain repertoi" doc
... metabolismAconoidasidaAgaricomycotinaAlveolataAmoebozoaAnnelidaApicomplexaArchaeplastidaArthropodaAscidiaceaAscomycotaBacillariophytaBasidiomycotaBikontaBilateriaEumetazoa (Bilateria ... HeteroloboseaLophotrochozoaMagnoliophytaMammaliaMetamonadaMetazoaMetazoa & ChoanoflagellataMicromonasMucoromycotinaNematodaOomycetesOpisthokontaOstreococcusPelagophyceae & BacillariophytaPezizomycotinaPlasmodiumPoalesPrasinophyceaePrimatesProtostomiaPucciniomycotinaRodentiaSaccharomycotinaSordariomycetesTeleosteiTheileriaTracheophytaUnikontaUrochordataUrochordata ... commonlyemployed for microarray analysis [48], to the functions of lost and gained domains enabled us to obtain a moredetailed view of the interplay between domain losses and gains (Tables 3 and...
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Báo cáo y học: "CEO- CNE Relationships: Building an Evidence-Base of Chief Nursing Executive Replacement Costs"
... American hos-pitals who were Association members. Systematic random sampling was done by choosing one of every three names obtained (from a random start point) for a total mailing of 780 yielding ... executives can have more than personal economic setbacks. Health-care financial instability caused by such major change in management is enormous and initiates placing the facility in crisis ... that may con-tribute to CNE longevity in position; an ethically diverse CNE deficit exists; and, CNE turnover and vacancy rates impact an organization’s financial health and quality of care....
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Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974
... birth-year cohort from a defined affluent geographical area and followed up to the age of 7 and 10 years. The study includes medical record examination and a ‘spectral analysis’ in remaining and ... regional quality program for asthma diag-nosis is nowadays shared, but was more lax 15 years ago than today, which introduces a possible bias since many of the NA cases were early diagnosed. Yet, ... Asthma could also be seen as a respiratory maladap-tation to modern lifestyles and to our increasingly artificial habitats and habits; not the least a progres-sive decrease of general physical...
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Tài liệu Báo cáo Y học: Dinucleoside polyphosphates stimulate the primer independent synthesis of poly(A) catalyzed by yeast poly(A) polymerase ppt
... properties of yeast poly (A) polymerase and on the intracellular role of dinucleosidepolyphosphates, a family of compounds of increasingmetabolic and regulatory interest [7–11].MATERIALS AND METHODSMaterialsPoly (A) ... poly (A) catalyzed by yeast poly (A) polymerase. The relativeactivity of diadenosine polyphosphates as effectors of the poly (A) synthesis was assayed as in Fig. 4, using0.05 mM [a- 32P]ATP as substrate, ... cleaving factors and a polyadenylationfactor [4,5]. The core yeast poly (A) polymerase appears tohave a molecular mass of around 63 kDa [3]. Separatedform the complex, the core yeast enzyme catalyzes...
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Tài liệu Báo cáo Y học: Trehalose-based oligosaccharides isolated from the cytoplasm of Mycobacterium smegmatis Relation to trehalose-based oligosaccharides attached to lipid docx
... interacting molecules and includes variouspolysaccharides such as mycolic acid–arabinogalactan and lipoarabinomannan, as well as a variety of complex glycoli-pids [1]. Among the interesting and ... MS analysis of the products obtained by permethylation and hydrolysis,andalsoby1H-NMR.Oligosaccharide CO3-2 appeared to be a trisaccharide, asMALDI-TOF MS analysis of the peracetylated oligosac-charide ... lipidMasaya Ohta1, Y. T. Pan2, Roger A. Laine3 and Alan D. Elbein21Department of Biochemistry, Fukuyuma University, Japan;2Department of Biochemistry and Molecular Biology,University of...
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Báo cáo Y học: ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity potx
... [6–8].Hydroxylation by clavaminic acid synthase (CAS/ORF5),followed by hydrolysis of the guanidino side-chain catalysed by proclavaminate amidino hydrolase (PAH/ORF4) yieldsproclavaminic acid ... racemicmixtures of certain amino acids with side chains containingpolar groups.The side-chain selectivity of the acetyl-acceptor wasprobed, assayingL-aspartate and D-aspartate,L -a- amin-oadipic acid,L-leucine, ... chiral starting materials for pharmaceutical production. Incubation of ORF6 with N-acetylornithine and arginine to produce N-acetylarginine, followed by incubation with CAS and appropriate cofactors...
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Báo cáo Y học: Propionate CoA-transferase from Clostridium propionicum Cloning of the gene and identi®cation of glutamate 324 at the active site pdf
... alanine according to theso-called randomising pathway with succinate a s a symmet-ric intermediate, C. propionicum ferments alanine via thenonrandomising pathway with acrylyl-CoA as c haracter-istic ... ).Detection of glutamate 324 as the catalyticcarboxylate of propionate CoA-transferaseAs the sequence analysis d id not allow an unequivocalidenti®cation of the catalytic glutamate of propionate CoA-transferase, ... sequence of Escherichia c oli K-12. Science 277, 1453±1474.28. Kawarabayasi, Y. , Hino, Y. , Horikawa, H., Yamazaki, S.,Haikawa, Y. , Jinno, K., Takahashi, M., Sekine, M., Baba, S.,Ankai, A. , et al....
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Báo cáo Y học: Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces docx
... Abcam (Cambridge, MA, USA);rabbit polyclonal antibody against enolase, mouse mono-clonal antibody against annexin II and rabbit polyclonalantibody against annexin II from Santa Cruz (Santa Cruz,CA, ... This cleavagewas inhibited by an MMP inhibitor, N-(R)-[2-(hydrox-yaminocarbonyl)-methyl]-4-methylpentanoyl-l-naphthyl-alanyl-l-alanine-2-aminoethyl amide (TAPI-1), but not by a mixture of inhibitors ... metalloproteinase; PVDF, poly(vinylidene difluoride); siRNA, small interfering RNA; TAPI-1, N-(R)-[2-(hydroxyaminocarbonyl)-methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine-2-aminoethyl amide;...
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