Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt

... signifi- cantly inhibited at nanomolar concentrations of RWJ 67657, and mRNA expression was also decreased, by nearly 50% at 10 nM. Inhibition of p38 MAPK activity leads to reduced TNF-α mRNA expression ... biosynthesis. Nat Cell Biol 1999, 1:94-97. 21. Bhattacharyya A, Pathak S, Datta S, Chattopadhyay S, Basu J, Kundu M: Mitogen-activated protein kinases and...

Ngày tải lên: 09/08/2014, 01:23

... regulation to maintain a narrow window between essential and pathological expression of BACE1. Sequential cleavage of amyloid precursor protein by BACE-1 and γ-secretase represents a central event ... proposed actions of BACE1-AS, promoting target mRNA stability by duplex formation and inhibiting miRNA-induced mRNA decay and translational repression, serve to ele...

Ngày tải lên: 09/08/2014, 20:22

... metabolism Aconoidasida Agaricomycotina Alveolata Amoebozoa Annelida Apicomplexa Archaeplastida Arthropoda Ascidiacea Ascomycota Bacillariophyta Basidiomycota Bikonta Bilateria Eumetazoa (Bilateria ... Heterolobosea Lophotrochozoa Magnoliophyta Mammalia Metamonada Metazoa Metazoa & Choanoflagellata Micromonas Mucoromycotina Nematoda Oomycetes Opisthokonta Ostreococcus Pelagophyceae &...

Ngày tải lên: 09/08/2014, 22:23

... American hos- pitals who were Association members. Systematic random sampling was done by choosing one of every three names obtained (from a random start point) for a total mailing of 780 yielding ... executives can have more than personal economic setbacks. Health- care financial instability caused by such major change in management is enormous and initiates placing the f...

Ngày tải lên: 26/10/2012, 08:57

... birth-year cohort from a defined affluent geographical area and followed up to the age of 7 and 10 years. The study includes medical record examination and a ‘spectral analysis’ in remaining and ... regional quality program for asthma diag- nosis is nowadays shared, but was more lax 15 years ago than today, which introduces a possible bias since many of the NA cases...

Ngày tải lên: 26/10/2012, 09:48

... properties of yeast poly (A) polymerase and on the intracellular role of dinucleoside polyphosphates, a family of compounds of increasing metabolic and regulatory interest [7–11]. MATERIALS AND METHODS Materials Poly (A) ... poly (A) catalyzed by yeast poly (A) polymerase. The relative activity of diadenosine polyphosphates as effectors of the poly (A) synthesis was as...

Ngày tải lên: 21/02/2014, 01:21

... interacting molecules and includes various polysaccharides such as mycolic acid–arabinogalactan and lipoarabinomannan, as well as a variety of complex glycoli- pids [1]. Among the interesting and ... MS analysis of the products obtained by permethylation and hydrolysis, andalsoby 1 H-NMR. Oligosaccharide CO3-2 appeared to be a trisaccharide, as MALDI-TOF MS analysis of the...

Ngày tải lên: 22/02/2014, 07:20

... [6–8]. Hydroxylation by clavaminic acid synthase (CAS/ORF5), followed by hydrolysis of the guanidino side-chain catalysed by proclavaminate amidino hydrolase (PAH/ORF4) yields proclavaminic acid ... racemic mixtures of certain amino acids with side chains containing polar groups. The side-chain selectivity of the acetyl-acceptor was probed, assaying L -aspartate and D -aspartate...

Ngày tải lên: 08/03/2014, 22:20

... alanine according to the so-called randomising pathway with succinate a s a symmet- ric intermediate, C. propionicum ferments alanine via the nonrandomising pathway with acrylyl-CoA as c haracter- istic ... ). Detection of glutamate 324 as the catalytic carboxylate of propionate CoA-transferase As the sequence analysis d id not allow an unequivocal identi®cation of the catalytic glu...

Ngày tải lên: 17/03/2014, 17:20

... Abcam (Cambridge, MA, USA); rabbit polyclonal antibody against enolase, mouse mono- clonal antibody against annexin II and rabbit polyclonal antibody against annexin II from Santa Cruz (Santa Cruz, CA, ... This cleavage was inhibited by an MMP inhibitor, N-(R)-[2-(hydrox- yaminocarbonyl)-methyl]-4-methylpentanoyl-l-naphthyl- alanyl-l-alanine-2-aminoethyl amide (TAPI-1), but not by a m...

Ngày tải lên: 17/03/2014, 17:20