Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx

... http:/ /arthritis- research.com/content/6/3/R213 Research article Induction of IL-10-producing CD4 + CD25 + T cells in animal model of collagen-induced arthritis by oral administration of type II collagen So-Youn ... antigen administration [8]. Although much of the RA pathogenesis remains to be elucidated, it has been reported that joint proteins, probabl...

Ngày tải lên: 09/08/2014, 01:23

... may enhance this response by inducing innate immunity through TLR triggering at the same time. Preliminary data suggest that a combination of both TCR and TLR activation causes induction of Tregs ... trial, patients suffering from recent-onset type 1 diabetes were treated by subcutaneous injections with epitope p277, the same epitope that enhances Treg function in vitro [61]. In...

Ngày tải lên: 09/08/2014, 14:20

... [39,40]. In mediating its suppressive effects, TGF-β signals through the type I and type II TGF-β serine–threonine kinase receptors, T RI and T RII. Interaction of the TGF-β ligand with these receptors ... and documentation of their in vivo potential was an important next step. In pursuit of this goal, recent studies demonstrated for the first time that the transfer of...

Ngày tải lên: 09/08/2014, 06:22

... similar in many respects to chronic in- flammation, due to its accumulation of lymphocytic infiltrates and long term induction of tissue remodel- ing. Therefore, we wanted to determine whether there ... S, Holt PG. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction...

Ngày tải lên: 03/11/2012, 11:24

... 1383 Increase in the steady-state level of the (2–5)A synthetase transcripts by LPS The effect of LPS on the steady-state level of (2–5)A synthetase transcripts, SD25A-1, was monitored by Nor- thern ... shown that the mitogen-activated protein k inase pathway is involved in the cell response to LPS [22]. Until now a potential involvement o f this pathway in the (2–5)A syntheta...

Ngày tải lên: 21/02/2014, 15:20

... vector +1 0 10 20 +446 RLU ETS A -734 GTACGCGGGACCGTCCTCCTGCCTACCCCTCCTTTTGCGACCAATCACCTTCGGGAATGGGGTCTCAGTCACACACACC CCAACACACACACACACACACACACACACACACACACACCACCACCACCACCACCACCACCACCACCACCACCACCAC CACCACCACCACCACCACACAGCGAGTGAGAGACTCAGTCTCTTCCTCCTCCTCCTCCTCCTCCTCCTCTCCCCCTCCCC CTCCCCTCCGTTTCCCACTTCTCGTCCCCTCCCCTCCTCCCCTCTCCCTCTTCCCCGTCTTCTCGTTCGTTCGTTTGCTCTT ETS TTCCTGT GACTGACTTGTCCGCACTAAC...

Ngày tải lên: 17/03/2014, 17:20

... an interesting autoantigen and may rep- resent a unique pathway leading to aggressive subtypes of RA. It is thus interesting to investigate this model further and to compare it with other models, ... the different strains do not exhibit a convincing correlation with arthritis susceptibility. Thus, high levels of antibodies to G6PI do not always lead to arthritis, indicating that othe...

Ngày tải lên: 09/08/2014, 07:20

... differ- entiation into the proinflammatory type of macrophages by increasing TNF receptors in RA, which is thought to partly explain the poor clinical efficacy of IL-10 therapy in the patients. Figure ... samples tested. Figure 2 Induction of monocyte expression of type 1 and type 2 interleukin-10 receptor (IL-10R1/2) by culture supernatants of rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 08:22

... expres- sion also indicates the possibility of a signal transduction path- way akin to that induced by the inflammatory cytokine pathway. Our data also indicate that the virulence gene loci (namely, Sar and ... might indicate the involvement of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by S. aureus. S. aureus culture supernatants and cell lysate...

Ngày tải lên: 09/08/2014, 08:23

... T cells in manifestations elsewhere than in the joints of patients with HCMV-seropositive rheumatoid arthritis. Introduction T cells are likely to play an important role in the pathogenesis of ... while the other dominant subset was clearly restricted (Figure 4c). Two patients did not display any of these distinct patterns of TCR-Vβ distribution. In all 13 patients,...

Ngày tải lên: 09/08/2014, 10:21