Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx
Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx
... MV, Dinarello CA:Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1- induced cytokine syn-thesis and blocks the binding of IL-1 to its type ... enhanced the production of IL-1Ra by human synovial fibroblasts and articular chondrocytes in the presence of the proinflammatory cytokines IL-1 and TNF-α. This might explain some of the protective ... http://arthritis-research.com/content/6/3/R181Research article The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytesGaby Palmer1, Danielle...
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Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
... behavioracross the day in contrast to endpoint where the majorityreported consistency in behavior. Further, at study end-point the majority of caregivers reported that handlingchanges in their child's ... socialinteractions since beginning the study medication, and 91.9% were satisfied with the efficacy of the study medi-cation on their child's attention. The majority of caregiv-ers (93.1%) indicated ... moderate in intensity, and the most commonlyreported AEs included headache, decreased appetite, insomnia, and abdominal pain. Seven subjects discontinued the study dueto intolerable AEs (n = 3) and...
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Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"
... history can be obtained by asking the indi-vidual “how many times do you laugh during your regular day?” and have the individual rate their level on a scale of one to ten. Furthermore, other ... hepatobiliary system, genitourinary system, reproductive system, CNS and psychiatric conditions, and then to specify the name of that con-dition. If the participant failed to indicate the name of the ... pertaining to age, gender, city of residence, annual income, and education were in- cluded. Specifically, age, gender and city of residence defined the parameters of the samples. Measurement of...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... domains or by specific phosphopeptides that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk for gastric atrophy. The biological ... especially cagA positive strains, plays a crucial role in the development of gastric atrophy and cancer [2,3]. CagA/ src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) interaction...
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Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes docx
... cytochromesP450 has identified domains in the primary sequence of human CYP17 which are involved in the catalytic activity of the enzyme, i.e. substrate docking and binding, the active site including ... formation of 16a-hydroxyprogesterone. Both expressed enzymes had nolyase activity towards PROG or 17-OHPROG.Understanding of the complexity of hydroxylase and lyase activity of CYP17 by way of primary ... quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248.26. Conley,A.J.&Bird,I.M.(1997)TheroleofcytochromeP45017a-hydroxylase and 3b-hydroxysteroid dehydrogenase...
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Báo cáo Y học: An active site homology model of phenylalanine ammonia-lyase from Petroselinum crispum docx
... amino acids in the chain A of the model, 43were outside of the likely Phi/Psi combinations in the Ramachandran plot (including Gly and Pro). Most of the deviations were found in the 64–531 and ... play a role in binding the carboxylate moiety of the substrate, whereasresidues Y1 10 and N260 can interact with amine/ammonia in the substrate and product, respectively. In the case of HAL it ... distances (A˚) in models for the zwitterionicL-phenylalanine binding (A), for the r-complex intermediate containing (B), and for the E-cinnamate/ammonia binding (C) state of the PAL active site...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
... protein quality between Pfg27A and the rest of the constructs was retained. Therefore, the differing proteinsolubilities were inherent in the constructs and could not bemodulated by varying the ... proteins were expressed and purified. Our results show that the fusion proteins werelabile and only partially soluble in five of the constructsresulting in very poor yields. Intriguingly, in the ... highlight the central issue that solubility of fusion proteins is not necessarily indicative of either properfolding or of increased solubility of the protein of interest.We propose that the success...
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Báo cáo Y học: Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis ppt
... Afterdetermination of the enzyme activity with the standardenzyme assay, the kinetic studies (Km, kcat) were completedfor the active muteins and for the wild-type enzyme.Enzyme and protein assaysProtein ... biosyntheticchain starting from tryptamine and secologanin and cata-lyses the conversion of polyneuridine aldehyde into the nextstable pathway intermediate, epivellosimine (Fig. 1). The enzyme ... replaced by alanine, the activity of the enzyme was lost completely (Table 2). With the Cys muteins, the results were variable. After mutatingCys213 and 257, the specific activity of the enzyme was...
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Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx
... withCa2+calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1,frenatin 3 and caerin 1. 9, all inhibit the activity of calcineu-rin, but at ... the presence of increasing concentrations of Ca2+calmodulin, the inhibition dropped by 50% in each case. In addition,these peptides also inhibit the activity of calcineurin, anotherenzyme that ... partly because they s howstructural similarity to the human brain endomorphins (e.g.YPWG-NH2) [23]. The sequences of two tryptophyllins areas follows: tryptophyllin L1, FPWL-NH2; tryptophyllinL2,...
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Báo cáo y học: "Hereditary angioedema: beyond international consensus - circa December 2010 - The Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie Lecture" pps
... pub-lished in HAE prophylaxis and therapy and these haveled to the licensing of pdC1INH (Berinert®,CSLBehr-ing; Cinryze®, ViroP harma; Ceto r-n®, Sanquin) in manyparts of the world; bradykinin ... C1 INHIBITOR (C1INH) If “failing” on demand therapy with any of the angioedema event therapies (AERx’s; pdC1INH, rhC1INH, bradykinin B2 receptor antagonist, kallikrein inhibibitor): Then ... per year with incapacity of 4 to 8 days. A step-up therapy with flaring, stabilize, and then reduce backto on demand is in use in many clinics in Canada and depending on the patient, is likely...
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