Báo cáo y học: "DEK binding to class II MHC Y-box sequences is gene- and allele-specific" pptx

... manner to the Y- box motifs in the promoter regions of several class II MHC genes, and that gene- and allele-specific Y- box poly- morphisms could affect DEK binding activity. In this study, we ... probes and competitors: HIV-2 DEK -binding site, class II MHC Y- box motifs (DQA1, DRA, DQB, and DRB), and related sequences. Probes and competitors include only...

Ngày tải lên: 09/08/2014, 01:23

... between this residue and the preceding amino acid is easily hydrolysed to yield a truncated pr otein and a C-terminal polypeptide, which is N-terminally blocked b y a pyroglutamyl residue [23]. To our ... 2520. 19. Hofmeister, A.E. & Buckel, W. (1992) (R.)-lactyl-CoA dehydra- tase from Clostridium propionicum. Stereochem istry of the dehy- dration of (R)-2-hydroxybutyryl-CoA...

Ngày tải lên: 17/03/2014, 17:20

... [2,19]. To the best of our knowledge, this is the first time that this particular isoform has been found to be specifically and exclusively overexpressed in cancer cells. Typically, TAp73 isoforms ... Cancer Cell 1, 49–52. 2 Tokuchi Y, Hashimoto T, Kobayashi Y, Hayashi M, Nishida K, Hayashi S, Imai K, Nakachi K, Ishikawa Y, Nakagawa K et al. (1999) The expression of p73 is increase...

Ngày tải lên: 29/03/2014, 09:20

... lupus erythematosus, coding for the immunoreceptor PD-1 [1]. The polymorphism identified, named PD1.3 and whose allele A is strongly associated with the disease, is so far the only polymorphism within ... pathways and identify susceptibility genes or susceptibility effects that might be epistatic, additive or independent. Similarly, the psoriasis study analyzed a region previously ide...

Ngày tải lên: 09/08/2014, 01:23

... strains. Discussion RA histology is typically characterized by pronounced synovial hyperplasia, also called 'pannus'. The RA pannus produces proinflammatory cytokines and proteases, and invades ... factors such as cytokines and growth factors [7-9], nuclear factor-kB activation [10], and angiogenesis [11]. The fibroblast-like synoviocyte (FLS) is a key player in this pro...

Ngày tải lên: 09/08/2014, 10:23

... Dunfee RL, Stanton J, Bogdan D, Taylor J, Kunstman K, Bell JE, Wolinsky SM, Gabuzda D: Macrophage entry mediated by HIV Envs from brain and ly mphoid tissues is determined by the capacity to use low ... assigned sequences into one of four classes: (i) Brain; (ii) Meninges, choroid plexus, and CSF; (iii)Bloodandlymphoid ;and( iv)Other.Meninges, choroid plexus, and CSF were grouped...

Ngày tải lên: 10/08/2014, 05:21

... It is easy to say, "the issue is communication," and it is easy to say "we have to talk to each other." But it is hard to collaborate, make meaning, and improvise. It is difficult ... transfer to more improvisa- tory, informal conversation. [61]. Summary The theory developed here is grounded in both the litera- ture of complex adaptive systems t...

Ngày tải lên: 11/08/2014, 05:21

... examined very easily by means of t his method. This method is applicable to the analysis of phosphorylated residues o n LBR fragments and protein kinases responsible for the phosphorylation. This method ... the binding of LBR to chromatin is important for c larifying the p hysiological function of the phosphorylation, and such work is currently underway. It was suggested that...

Ngày tải lên: 22/02/2014, 04:20

... variability of synovial membrane his- tology, immunohistology, and cytokine mRNA expression in patients with rheumatoid arthritis. J Rheumatol 1999, 26:777- 784. 19. Hub E, Rot A: Methods for study of ... immuno- histochemistry or flow cytometry have the advantage of molecular identification, but can not show definitively if the receptors bind ligands. Immunohistochemistry showed that both...

Ngày tải lên: 09/08/2014, 03:24

... set enrichment analysis; H3K4 me3: histone H3 trimethyl-lysine 4; H3K27 me3: histone H3 trimethyl-lysine 27; HIF-1: Hypoxia-inducible factor-1; MAT: Model-based Analysis of Tiling-array; qPCR: quantitative ... simi- lar to the findings for Myc, which preferentially binds to sites with H3K4 and H3K79 methylation and histone H3 acetyla- tion [30,31]. Although Myc and HIF-1 binding...

Ngày tải lên: 09/08/2014, 20:20