Báo cáo y học: "Cytokines in systemic lupus erythematosus, London, UK" ppt

... of Meeting report Cytokines in systemic lupus erythematosus, London, UK Anisur Rahman Centre for Rheumatology, Department of Medicine, University College London, London, UK Corresponding author: ... many different cytokines may be involved. Second, although many cytokines may be involved in the pathogenesis of SLE, research thus far has concentrated on a small group of cytokines...

Ngày tải lên: 09/08/2014, 01:22

... this disease. Keywords: Epstein–Barr virus, Epstein–Barr virus type, systemic lupus erythematosus, virus burden Introduction Systemic lupus erythematosus (SLE) is an idiopathic dis- ease characterized by variable ... in EBV type distribution in Figure 1 Epstein–Barr virus (EBV) typing of normal individuals and patients with systemic lupus erythematosus (SLE) in mouthwash s...

Ngày tải lên: 09/08/2014, 01:23

... reliably and relatively easily determined; and (3) ascertaining that there is a close relationship between the marker and the outcome or characteristic of interest. In systemic lupus erythematosus ... likely utility in SLE, and to propose a schema through which to test and apply them. The review of the literature was done by traditional methods: searching by key words and search engin...

Ngày tải lên: 09/08/2014, 01:23

... Further RCTs on early SSc are needed to assess the real efficacy of CYC in inducing remission and increasing survival. In a previous issue of Arthritis Research & Therapy, Nannini and colleagues ... by a well-conducted meta-analysis and concluded that cyclophosphamide (CYC) treatment does not induce a statistically significant improve- ment in lung function in systemic sclerosis...

Ngày tải lên: 09/08/2014, 01:22

... important signaling pathways involved in the control of the IL-1/IL-1Ra balance in human monocytes, in so far as inhibition of phosphatidylinositide 3 kinase delta markedly decreases IL-1 while increasing ... the main problem is in fact the inhibition of repair activity. Any type of chronic joint inflammation, whether infectious, inflammatory, or autoimmune, will result in joint des...

Ngày tải lên: 09/08/2014, 14:22

... Therapy, in which they describe cytokine patterns of inflamed joints from patients with Behçet’s disease (BD). The authors show that neutrophils and T lymphocytes are involved in a Th1-skewed inflammatory ... terminated while TNF blockage was continued. Cytokines were evaluated in the resected colon by analyzing mRNA expression levels of cytokine genes as previously described [2]. Becau...

Ngày tải lên: 09/08/2014, 14:22

... is included in the study. Results showed a 5% to 10% improvement in prediction using combined versus single biomarkers – a definite improvement on existing biomarkers. This is an important principle ... efficacy of intervention and diagnostic) recommendations [4]. As the authors comment, the use of the current suboptimal method for determining OA radiographically is a weakness and only ea...

Ngày tải lên: 09/08/2014, 14:22

... from Pharmingen-Becton Dickin- son (San Diego, CA, USA). Biotinylated antibodies were detected using an allophycocyanin-conjugated streptavidin antibody (Pharmingen-Becton Dickinson). Staining was ... units. The analysis was done blind and 50 glomeruli per section were analysed. Flow cytometry Flow cytometry was performed using a three colour staining on spleen cells and thymocytes and analys...

Ngày tải lên: 09/08/2014, 07:20

... expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int Immunol 2001, 13:1583-1593. 9. Youinou P, Lydyard PM, Mageed RA: B cells underpin lupus immunopathology. Lupus ... = interleukin; MHC = major histocompatibility complex; SLE = systemic lupus erythematosus. Available online http://arthritis-research.com/content/5/4/157 Introduction: B cell...

Ngày tải lên: 09/08/2014, 01:21

... procollagen prolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX) and lysyl hydroxylases (procollagen lysyl hydroxylase and procollagen lysyl hydroxylase 2). Similar links between hypoxia and ... changes in systemic and cellular oxygen concentrations induce a tightly regulated machinery of short-acting and long-acting response pathways to keep the supply of oxygen within the physiolo...

Ngày tải lên: 09/08/2014, 01:22