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Báo cáo y học: "Innovative combination strategy to enhance effect and diminish adverse effects of glucocorticoids: another promise" pot

Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc

Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc

... cofactor forL. donovani interaction with ECM and BM. Both Zn2+ and free sulfhydryls may be required for LBP binding site onlaminin a s e videnced by the stimulatory and inhibitory effects of ... protein of Leishmaniais stimulated by zinc and may involve lamininzinc-finger like sequencesKeya Bandyopadhyay, Sudipan Karmakar, Abhijit Ghosh and Pijush K. DasMolecular Cell Biology Laboratory, ... [26] and RGD [27] did not show any inhibitoryactivity (data n ot shown). A ll these molecules with adher-ence inhibitory activity could effectively block lamininbinding to LBP (Table 2).Tyrosine...
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Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

... activation of the corresponding phosphatases.Lastly, our data reveal a multiplicity of effects of cellstresses on translation regulators, and their profoundinhibitory effect on protein synthesis. ... consequences of toxic effects leading to a loss of cell viability.In view of this substantial inhibition of proteinsynthesis, it will be important to consider their effects on protein synthesis ... of 0.5mL,andtrypanbluewasaddedtoaconcentrationof0.4% (w/v) to the cell suspension. Cells were transferred to ahaemocytometer and inspected visually for their ability to exclude the stain. Viability...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf

Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf

... form, affinity chroma-tography was then used to purify PAK68. The autophos-phorylation and kinase activity of PAK were stimulated bybinding to activated Rac/Cdc42, which thereby directlymodulates ... antibodies, and poly-clonal antibodies to PAK65 and to PAK62 were obtainedfrom Santa Cruz Biotech, Inc. Polyclonal antibodies to human gp91phox and Rac1 were kindly provided by D. J.Lambeth (School of ... 95%neutrophil granulocytes.Measurements of reactive oxygen speciesSuperoxide generating activity was spectrophotometricallyassayed by monitoring SOD-inhibitable ferricytochrome creduction...
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Báo cáo y học: "Maternal Outcomes According to Placental Position in Placental Previa"

... level of prior to surgery, 1 day after surgery, and 3 days after surgery, the amount of transfusion during surgery, estimated blood loss during operation, pla-cental accreta, hysterectomy, myomectomy, ... parity, history of cesarean section and history of abortion should be adjusted when demographic investigation on placenta previa is pursued [1]. In our study, in addition, to evaluate the effect ... risk factors for peripartum hysterectomy are previous cesarean section, history of abortion, and complete previa [6]. Until now, placental previa has been classified by the degree of encroachment...
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Báo cáo y học: " Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance"

... inflam-mation, fatty liver and IMT to explore as to which of these factors are related to IMT. Subjects and Methods Subjects A total of 86 obese Chinese children were enrolled from July 2008 to March ... intra-assay and inter-assay coefficient of variations were less than 2.1% and 4.4%, respectively. Plasma levels of IL-6 and TNF were measured by en-zyme-linked immunosorbent assay method (Ju Ying ... care and organization. This work was supported, in part, by grant of Zhejiang Science and Technology Agency (2008C03002-1) and Zhejiang Major Medical and Health Science and Technology &...
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Báo cáo y học: " A Practical Approach to Managing Patients with HCV Infection"

... assessment of the severity of the liver disease. During each follow-up, signs and symptoms of possible adverse effects should be evaluated. If treatment is continued in the presence of adverse effects, ... weighed by the severity of disease, the predicted success rate, the anticipated adverse effects and the cost and availability of the drugs. The decision to treat should never be made by the physician ... Selection of Patients for Treatment of Chronic HCV 1) Why to Treat HCV Infection The treatment of HCV is justified by the natural history and the outcome of chronic infection and liver injury that...
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Báo cáo y học:

Báo cáo y học: "A Practical Approach to Management of Chronic Hepatitis B"

... treatment [16]. 4. Indications of HBV Treatment Historically, levels of HBV DNA and ALT, and histological activity of liver biopsy have been used as the three main factors to determine if a patient ... On-treatment Monitoring and Duration of Therapy Patients who receive HBV treatment should be monitored regularly. The interval of follow-up visits may vary depending on regimen and duration of the HBV ... HBV is not directly pathogenic to hepatocytes and host immune response to HBV antigens expressed on the infected hepatocytes is the principle determinants of the liver injury. Thus, a high HBV...
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Báo cáo Y học: Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice pdf

Báo cáo Y học: Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice pdf

... [5–16]. How-ever, very few cases of human obesity are reported to be caused by genetic factors [17], leaving western-typediet and sedentary lifestyle, physical inactivity and imbalance in caloric ... in thedelivery of nonhydrolyzed dietary lipids to adiposetissue. Taken together, our data establish that ApoE isa key mediator of diet-induced obesity in response to western-type diet.ResultsApoE ... contribute to the accu-mulation of excess lipids in the liver in response to western-type diet (Fig. 6A). Effects of ApoE and LDLr deficiency on the directdelivery of dietary lipids to adipose...
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Báo cáo Y học: Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I pptx

Báo cáo Y học: Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I pptx

... interesting to analyze the binding specificity of thedifferent types of importin a toNLD-INLSandtotheputative NLD-I type NLSs present in other nuclearproteins.ACKNOWLEDGEMENTSWe wish to thank ... 265–306.14. Miyamoto, Y. , Imamoto, N., Sekimoto, T., Tachibana, T., Seki,T., Tada, S., Enomoto, T. & Yoneda, Y. (1997) Differential modes of nuclear localization signal (NLS) recognition by three ... analysis of the recognition of a nuclear locali-zation signal by the nuclear import factor karyopherin alpha. Cell94, 193–204.21. Conti, E. & Kuriyan, J. (2000) Crystallographic analysis of...
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Báo cáo hóa học:

Báo cáo hóa học: " A New Strategy to Improve Proactive Route Updates in Mobile Ad Hoc Networks" ppt

... metric. Another way to determine if an update is required is bymonitoring the nearby topology and disseminating updatepackets only when a minimum level of topology change oc-curs. To do this, ... periodically maintains the nearby topology by employ-ing a proactive routing strategy (such as distance vector orlink state) and maintain approximate routes or on-demandroutes for faraway nodes.In ... data to send to the destination). The advantage of on-demand protocolsis that they reduce the amount of bandwidth usage and re-dundancy by determining and maintaining routes when theyare required....
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