Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc

... signaling via CD20 Commentary B cells as a therapeutic target in autoimmune disease Jörg J Goronzy and Cornelia M Weyand Departments of Medicine and Immunology, Mayo Clinic, Rochester, MN, USA Corresponding ... diseases. Preliminary clinical studies suggest therapeutic benefits in patients with classic autoantibody-mediated syndromes, such as autoimmune cytopenias. Treat...

Ngày tải lên: 09/08/2014, 01:21

... between syno +/+ and syno +/− mice. No advanced synovial cell hyperplasia was detected in CIA-syno +/− mice, even though inflammatory cell infiltration was clearly observed in them. Detailed analysis ... Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Kitajima I, Nishioka K, Yamamoto K, Takeda T, Hatanaka M, et al.: Induction of inflammatory arthropathy resembling rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 07:20

... suggest a causal relationship between PBC and infection, such as case clustering within well-demarcated geographical areas and an increased risk of recurrence after liver transplanta- tion with increasing ... μmol/L), C-reactive protein (75 mg/L), alanine aminotransferase (ALAT, 120 U/L), gamma-glutamyl trans- ferase (ү-GT, 240 U/L) and bilirubin (27 μmol/L). A test for malaria was nega...

Ngày tải lên: 11/08/2014, 14:20

... the patient, diagnosis and preparation of this case report: Zulifqar Ali, Irshad Ahmad and Zikria Rasheed of the Department of Surgery, Madina Teaching Hospital, Faisalabad, Pakistan; Saadia Hameed ... Department of Pathology, Madina Teach- ing Hospital and University Medical College Faisalabad, Pakistan; and Rana Qaiser Mehmood of the Department of Pathology, Punjab Medical College, Faisalab...

Ngày tải lên: 11/08/2014, 14:20

... Case report Open Access Serous labyrinthitis as a manifestation of cat scratch disease: a case report Ilias Kantas 1 *, Michael Katotomichelakis 2 , Marinos Vafiadis 1 , Zografia V Kaloutsa 1 and ... with many clinical manifestations as well as a cosmopolitan emerging human pathogen [3]. Typical CSD can occur in all ages. Usually, 3 to 10 days after contact with an infected cat,...

Ngày tải lên: 11/08/2014, 17:21

... presentation may vary from asymptomatic to swelling of external genitalia, dysuria, poor urinary stream or retention, bloody or purulent urethral discharge and ascending urinary tract infection [1,2]. Depending ... this act as an indication of an impul- sive behavior, self-punishing in nature that may aggravate to suicide [1]. The psychiatric evaluation is controversial as many of these...

Ngày tải lên: 11/08/2014, 19:21

... of granulation tissue has been associ- ated with a number of factors notably mechanical irrita- tion and microbial infection with bacteria such as P. aeruginosa and S. aureus [5], as well as fungi ... several microlaryngoscopy, laser and dilatation procedures to restore airway lumen, and had a soft silastic stent in situ to maintain luminal pat- ency. However, he continued to have...

Ngày tải lên: 11/08/2014, 23:21

... 62:101-107. 36. Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, et al: Genetic association between the interleukin-2 receptor-alpha gene and ... suggesting a role of IL-2 as a key player in Treg cell plasticity and heteroge- neity. These studies also shape our thinking as some human trials have been initiated that use...

Ngày tải lên: 18/06/2014, 16:20

... BM by increasing T cell activation, a phenomenon that results in increased T cell proliferation and life span. Ovx increases T cell activation by enhancing antigen presentation by BM macrophages ... confirmed in humans, it will, perhaps, be appropriate to classify osteoporosis as an inflammatory, or even an autoimmune condition and certainly new therapeutic ‘immune’ targets will e...

Ngày tải lên: 09/08/2014, 10:20

... protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells Franca Majone* 1 , Roberto Luisetto 1 , Daniela Zamboni 1 , ... Zamboni 1 , Yoichi Iwanaga 2 and Kuan-Teh Jeang 2 Address: 1 Department of Biology, University of Padua, Padua, Italy and 2 Laboratory of Molecular Microbiology, NIAID, NIH, Bethe...

Ngày tải lên: 13/08/2014, 09:21