Báo cáo y học: "Role of Genetic Polymorphisms in Therapeutic Response to Anti-Asthma Therapy" pot

... regarding potential phenotypic and genotypic indicators of response to therapy because one or the combination of both of these tools will likely be a clue to a patient’s response to therapy. References 1. ... therapy, focusing on a potential genetic clue to medication response. Key words: asthma, genetic polymorphisms O ur understanding of the pathophysiology and t...

Ngày tải lên: 08/08/2014, 21:20

... Excessive production of IFN-γ in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J Immunol ... developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun 2008, 9:379-382. 12. Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nak...

Ngày tải lên: 09/08/2014, 13:22

... production of soluble osteoclastogenic cytokines. Blood 2000, 96:1873-1878. 8. Miyaura C, Onoe Y, Inada M, Maki K, Ikuta K, Ito M, Suda T: Increased B-lymphopoiesis by interleukin 7 induces bone loss in ... pathway. This is supported by recent findings demonstrating TNFα-independent IL-7-driven inflammatory and bone-destructive activity [6,7]. IL-7 is also able to regulate joint pathol...

Ngày tải lên: 09/08/2014, 10:23

... the Y2 38 mutants to catalyse D -alanine/ oxygen catalysis was measured by enzyme-monitored turnover [21]. Air-saturated solutions of Y2 38 mutant enzymes and of D -alanine were mixed in the stopped-flow spectrophotometer ... phe- nylalanine and serine in the enzyme from the yeast Rhodo- torula gracilis. The mutated proteins are catalytically competent thus eliminating Tyr238 as an...

Ngày tải lên: 17/03/2014, 17:20

... at present, able to fully rationalize. Replacement of the distal His42 by alanine renders the H42A enzyme essentially inactive, which is presumably directly linked to the very poor reactivity of this ... performed by global analysis and numerical integration methods using PROKIN software (Applied Photophysics). RESULTS Mass spectrometry The integrity of the variant proteins was exam...

Ngày tải lên: 18/03/2014, 01:20

... described [16]. In brief, for each genotyping experi- ment 10 ng DNA was used in a total volume of 5 μl containing 1 × TaqMan ® Genotyping Master Mix (Applied Biosystems Foster City, CA, USA). ... Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study 5. PLoS ONE 2008, 3:e1948. 17. Olerup O, Zetterquist H:...

Ngày tải lên: 09/08/2014, 14:20

... (nGNTInfer), inferring transcriptional regulatory networks from high-throughput data (nTRNInfer), inferring protein-protein interactions by parsimony principle (nInferPPI), inferring protein-protein ... correlated with clinical informatics, including patient complaints, history, therapies, clinical symptoms and signs, physician’s examinations, biochemical analyses, imaging profiles, path...

Ngày tải lên: 10/08/2014, 09:22

... representation of the potential pro-inflammatory role of IL-33 in normal skin and in skin inflammation (atopic dermatitis and psoriasis). Damage to the skin such as by scratching in response to an allergen ... accessory protein (IL-1RAcP) [4-6]. Sig- naling is induced through the cytoplas mic Toll-interleu- kin-1 receptor (TIR) domain of IL-1RAcP. This leads to recruitment...

Ngày tải lên: 11/08/2014, 03:20

... 7 of 8 (page number not for citation purposes) clinical location is necessary prior to using such debride- ment tools, particularly as hydro-surgery consoles are becoming increasingly used in ... this study was therefore to evaluate the potential for aerosolization of microbes during hydrode- bridement therapy and additionally determine the effec- tiveness of hydro surgery in re...

Ngày tải lên: 10/08/2014, 21:23

... These include include b-conglycinin, glycinin, soy vacuolar protein, Kunitz trypsin inhibitor, and other proteins [83,87-89]. Awazuhara et al detected IgE- and IgG4-binding proteins in soybean ... predominant proteins in soybean are the storage proteins, namely 7S globulin (conglycinin) and 11S globulin (glycinin), which comprise approxi- mately 80% of the total proteins [26]. Oth...

Ngày tải lên: 31/10/2012, 14:59