Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps

... 258 Rajinder Raina et al.Tabl e 1 . Effects of chronic dermal application of cypermethrin on enzymes, blood glutathione and lipid peroxidation in Wistar rats ParametersDays after dermal applicationControl ... study may be due to either the inhibition of GSH synthesis or increased utilization of GSH for detoxification of toxicant induced free radicals [33]. The decrease in SOD, blood GSH and GSH-Px suggests ... 1975.5. Chinopoulos C, Tretter L, Rozsa A, Adam-Vizi V. Effect of cypermethrin on oxidative stress after dermal application 259Exacerbated responses to oxidative stress by an Na+ load in isolated...

Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc

... oxidative stress, and we now show the response of this organism to oxidative stress and the role of PARP during development. We used hydroxylamine (HA) to induce in situ generation of H2O2 and monitored ... effect of benzamide, a PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited ... observed during oxidative stress (Fig. 4A,B). Under oxidative stress, partial inhi-bition of PARP activity led to altered growth, suggest-ing that oxidative stress could be leading to cell cyclearrest...

Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx

... and release of cytochrome c from mitochondria in F9 cells exposed to hydrogen peroxide, and our resultsFig. 7. Suppression of oxidative stress- inducedapoptosis in F9 cells by a potent p38 inhibitor.F9, ... caspase-3,poly(ADP-ribose)polymerasecleavage,cytochrome crelease and activation of p38 mitogen-activated protein kinase(p38). Furthermore, oxidative stress- induced apoptosis wassuppressed by SB202190, a potent inhibitor of p38, in F9cells. ... fractionatedinto mitochondrial and cytosolic fractions and cytochrome cwas examined by Western blotting, a large amount of cytochrome c was found in mitochondria with only a smallamount in the cytosolic...

báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx

... University of Lausanne. Writ-teninformedconsentwasobtainedpriortostartofthestudy, in addition to questionnaires destined to collectinformation on possible confounding factors (cigarettesmoke, eating ... only 10% of urate is excreted in the urine (theremaining 90% being recirculated by the renal system[3]), an increase of this antioxidant in blood will alsolead to an increase in urine. The ... and 73 ± 12% (n = 5), respectively.Urinary concentrations of 8OHdG were ratioed to crea -tinine for normalization, and the results expressed in terms of μg 8OHdG/g cre atinine. The creatinine...

Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc

... efficient. 1 Introduction Learning to read and write Chinese characters is a challenging task for learners of Chinese. To read everyday news articles, one needs to learn thou-sands of Chinese characters. ... read-ing ability, e.g., (Siok and Fletcher, 2001). Moreo-ver, the ability to detect and apply phonological consistency in GPCs, including the roles of PCs in PSCs in Chinese, plays an instrumental ... characters learning: System design and development, Proc. of the Int’l Conf. on Edutainment, 559–564. C Y. Lee. 2009. The cognitive and neural basis for learning to reading Chinese, J. of Basic Education,...

Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx

... studies of inactive and active Src, the SH2 and SH3 domains are believed to form a ‘regulatory apparatus’. Binding of the phos-phorylated C-terminus to the SH2 domain and ⁄ orbinding of the SH2-kinase ... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to thesubstrate and thereby preventing interaction of the substrate with the kinase domain. For ... state of the kinase by preventing itfrom reverting to the auto-inhibitory state [33]. In Src and Abl kinases, the SH2 domain can act in conjunctionwith an additional SH2 or SH3 domain to maintain...

Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modiﬁcation of the 20S proteasome docx

... a critical role in the function of many proteins, including enzymes, transcription factors and membrane proteins [35]. In a previous report, weconcluded that oxidative stress induced proteasomeglutathionylation ... °C and afterwards applied to 20% SDS–PAGE. Lane 1represents standard Grx2 (ST-Grx2) incubated in standard bufferwithout n-PT, and lanes 2–4 represent of Grx2 incubation in thepresence of n-PT ... after simultaneous incubation of proteasomepreparations with cardiolipin and Grx2. The resultsobtained showed 25% and 65% increased chymotryp-sin-like activity and 61% and 100% increased post-acidic...

Báo cáo khoa học: Function of microRNA-375 and microRNA-124a in pancreas and brain doc

... miR-375 and the 3¢-UTR of myotrophinmRNA was shown to repress myotrophin translation and result in the inhibition of insulin secretion. In addition to its role in exocytosis control, myotrophinis ... insulin exocytosis machinery[miR-124a increases the levels of synaptosomal-associated protein 25 (SNAP25), Ras-related proteinRab-3A (Rab3A) and synapsin-1A and decreases those of Rab27A and ... ﬁndings representanother interesting aspect of the action of myotrophin in cells and may explain the mechanism by whichmiR-375 also mediates insulin exocytosis. Of course,more work needs to...

Báo cáo khoa học: "Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis" potx

... Immunohistochemical stainingrevealed exclusive nuclear staining of the neoplastic cellsfor cyclin D1, cyclin E and PCNA. Cyclin D1 expressionwas detected in 56.3% of the adenomas and in 61.5% of the ... T., Morris R. and Klein-Szanto A.J.P. Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms. Mol.Carcinogenesis 1997, ... for cyclin D1, cyclin E, PCNA and HPRTrevealed product bands of the expected size. The results of autoradiography are shown in Figure 1. The width and intensity of the cyclin D1, cyclin E and PCNA...

Báo cáo khoa học: "Prevalence of Bartonella henselae and Bartonella clarridgeiae in cats and dogs in Korea" ppsx

... KoreaIntroduction The genus Bartonella (B.) includes at least 20 species and subspecies, and several of these are human pathogens [22]. Clinical manifestations of Bartonella infection include ... Control for the detection and differentiation of Bartonella henselae and B. clarridgeiae: an examination of cats in Trinidad. BMC Infect Dis 2005, 5, 63.16. Rolain JM, Locatelli C, Chabanne ... Raoult D. Prevalence of Bartonella clarridgeiae and Bartonella henselae in domestic cats from France and detection of the organisms in erythrocytes by immunofluorescence. Clin Diagn Lab Immunol...

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