... alanine scanning of the L-CDR3 and H-CDR3 loops of antibody mAb4E11. This scanning allowed us to identify the residues of these loops that contributed to the energetics and kinet- ics of the interaction ... mAb4E11 and its antigen. It showed that the residues of diversity, H-Trp96 and H-Glu97, and the residues of junction, L-Trp96, H-Gly95 and H-G...
Ngày tải lên: 19/02/2014, 07:20
... that the isolated canonical EF-hand alone has an intrinsic tendency to form a dimer, which is in agreement with the EF-hand pairing paradigm. Clearly, the canonical EF-hand motif alone is able ... engineered protein CD2 .STIM1. EF increased, indicating that the inserted EF-hand motif at least partially maintains the natural helical structure after grafting. The Ca 2...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học "ADIABATIC TEMPERATURE RISE AND REACTION RATE OF MASS STRUCTURE IN LOTTE CENTER HANOI PROJECT " pptx
... measured results (Center) The value compared between measured and analyzed (Center) ADIABATIC TEMPERATURE RISE AND REACTION RATE OF MASS STRUCTURE IN LOTTE CENTER HANOI PROJECT Dr. KIM ... thermal crack index is over 1.0 and a curing time of mass- section foundation decreases within 18 days through minimizing binders in concrete and adjusting...
Ngày tải lên: 07/03/2014, 03:20
Báo cáo khóa học: O-acetylation and de-O-acetylation of sialic acids in human colorectal carcinoma docx
... (1989) O-acetylation and de -O-acetylation of sialic acids. O-acetylation of sialic acids in the rat liver Golgi apparatus involves an acetyl intermediate and essential histidine and lysine residues–a ... questions concerning the occurrence and enzymatic processes involved in the O-acetylation and de -O-acetylation of sialic acids in human colonic ti...
Ngày tải lên: 07/03/2014, 14:20
Báo cáo khoa học: Protein stabilization by compatible solutes Effect of diglycerol phosphate on the dynamics of Desulfovibrio gigas rubredoxin studied by NMR docx
... Protein stabilization by compatible solutes Effect of diglycerol phosphate on the dynamics of Desulfovibrio gigas rubredoxin studied by NMR Pedro Lamosa 1 , David L. ... dynamic behaviour of proteins in the presence of solutes is expected to shed light on the stabilization phenomenon. Desulfovibrio gigas rubredoxin (RdDg), a small iron...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast docx
... point mutations in the native Hsp90 of yeast render cells much more sensitive to Hsp90 inhibitor drugs To test whether mutations in the native Hsp90 chaperone of yeast influence sensitivity to Hsp90 ... of Hsp90 system cochaperones and plasma membrane ATP binding cassette (ABC) transporters can sensitize cells to Hsp90 drugs Hsp90 wor...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf
... al. Oxymethylene diadenosine polyphosphate analogs FEBS Journal 276 (2009) 15461553 ê 2009 The Authors Journal compilation ê 2009 FEBS 1551 Novel diadenosine polyphosphate analogs with oxymethylene ... to understand their biological functions has been through the use of Np n NÂ analogs. Here, we present the results of studies using novel diadenosine polyphosph...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3 pot
... (5Â-TCCCGTGTGT GCAGACCATCTTGAAT -3 ), H528A forward primer (5Â-TCCCGTGTGTCAAGACGCTCTTGAAT -3 ) or H 52 8S forward primer (5Â-TCCCGTGTGTCAAGACTCTCTTG AAT -3 ) and reverse primer (5Â-AGTCCCGGGGTGTT CATGTATGCTC -3 ). ... C, Cai Z, Kim YC, Kumar R, Yuan F, Shi PY, Kao C & Luo G (2005) Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf
... Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 Maya Guncheva 1 , Ivaylo Ivanov 2 , ... atoms of the main chain CO groups of LeuB387 and TrpB240, Od 1 atom of AsnB241, and Oc atom of SerB386 and is expected to stabilize the po...
Ngày tải lên: 16/03/2014, 16:20
Báo cáo khoa học: NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon ¨ Methanosarcina mazei Go1 pot
... to the NrpRI ⁄ NrpRII complex decreases the binding affinity of NrpRI to the operator as well as decreasing the NrpRII binding affinity to the general transcription factors, potentially by inducing ... studied the binding properties of NrpRII to the general transcription factors – TATA-binding protein (TBP) and the archaeal homolog of the eukaryotic gen...
Ngày tải lên: 29/03/2014, 21:20
Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx
... FEBS 4993 MINIREVIEW Relaxin-3 ⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka Department of Basic Geriatrics, Kyoto Prefectural University ... Relaxin-3 is so named because it has a motif that can interact with the relaxin receptor. By contrast to other relaxins, relaxin-3 is mainly expressed in the...
Ngày tải lên: 29/03/2014, 21:20
Báo cáo khoa học: "Collaborative control initiatives targeting zoonotic agents of alveolar echinococcosis in the northern hemisphere" ppsx
... because of the cost of the drug, the replacement of sled-dogs by machines decreased remarkably the incidence of alveolar echinococcosis in the island. However, with the presence of other definitive ... Taken together, these findings indicate that invasion of young infected foxes into the territories left by the hunted foxes could maintain or increase th...
Ngày tải lên: 07/08/2014, 20:23
Báo cáo khoa học: "general overview with a seasonal assessment silver fir forest in the Vosges mountains (France)" docx
... class="bi x0 y0 w1 h0" alt="" Review article Aluminium toxicity in declining forests: a general overview with a seasonal assessment in a silver fir forest in the Vosges mountains ... performant Ca/Al ratio and is used in a declining fir stand in the Vosges mountains (eastern France). A potential Al toxicity phase was observ...
Ngày tải lên: 08/08/2014, 19:21
Báo cáo khoa học: "Marjolin''''s ulcers: theories, prognostic factors and their peculiarities in spina bifida patients" ppsx
... Access Marjolin’s ulcers: theories, prognostic factors and their peculiarities in spina bifida patients Peter M Nthumba Abstract Background: Due to improved care, more and more children born with spina bifida ... different prognostic factors, with a view to applying these to spina bifida patients. This understanding would aid the healthcare worker in develop...
Ngày tải lên: 09/08/2014, 03:23
Báo cáo khoa học: " Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors" docx
... Central Page 1 of 7 (page number not for citation purposes) Radiation Oncology Open Access Research Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral ... pro- tocol for patients with medically inoperable small periph- eral stage I lung cancer and single small peripheral lung metastases. Continu...
Ngày tải lên: 09/08/2014, 10:21