Ngày tải lên: 07/08/2014, 20:23
... flask-shaped invaginations of the plasma membrane and also by the presence of the structural protein caveolin (isoforms 1–3) [1]. Caveo- lin-1 and caveolin-2 are found in most cell types, inclu- ding ... iden- tified herein, which further justifies referring to all of them as caveolae, was demonstrated by their content of both caveolin-1 and caveolin-2. The coexistence of caveo...
Ngày tải lên: 16/03/2014, 13:20
Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... [238–240]. Even in the absence of pro- tein–protein interactions, factors can assist each other’s binding to DNA within nucleosomes. This principle is illustrated in the model shown in Fig. 7A. In this ... transcribed regions of active genes in human T cells [124]. In a study in yeast, mutations were introduced alone or in combination in lysines 5, 8, 12 and 16 in th...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
... repressing the indicated targets and presumably hundreds of other as yet unidentified targets. (B) miR-34a and the miR-34a-binding site in the 3¢ UTR of genes shown in (A). miRNAs and cell signaling ... signaling pathways but, in turn, the induced miRNAs regulate these pathways by repressing the expression of components of the signal- ing pathways and, in some cases, com...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Expression and secretion of interleukin-1b, tumour necrosis factor-a and interleukin-10 by hypoxia- and serum-deprivation-stimulated mesenchymal stem cells Implications for their paracrine roles ppt
... [ 3 H]-Thymidine or [ 3 H]-proline (Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China) was added to each well to a final concentration of 1 lCiÆmL )1 during the last 6 h of incubation. ... P i washes and incubation with the nuclear stain 4¢,6-diamidino-2-phenylindone for 20 min, the MSCs were washed in NaCl ⁄ P i for 10 min and mounted in gelvatol fo...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx
... differently from the rest of the promoters. Of these, amino acid residues 243 and 275 are involved in DNA binding and 244 and 246 are in very close proximity to DNA binding. This indi- cates that p53R2 ... within the safety margin are classified as having unknown severity. In Table 9, the prediction accuracy is shown using difference sizes of the safety margin. By increasing...
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Isolation and characterization of four type 2 ribosome inactivating pulchellin isoforms from Abrus pulchellus seeds docx
... chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry 12, 3121–3126. 21 Olsnes S & Pihl A (1973) Isolation and properties of abrin: a toxic protein inhibiting protein ... suboptimal binding of GalNAc in one or both binding pockets of P I. However, in striking contrast with the rescue of protein synthesis observed for P I and P II, protection against...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
... (PX) domain in the N-terminus. PX domains occur in a variety of proteins involved in cell signaling, mem- brane trafficking, and polarity establishment, and func- tion as phosphoinositide-binding modules ... in the testis and fetal brain. The Noxo1c protein contains an additional five amino acids in the N-terminal PX domain, a phosphoinosi- tide-binding module; the domain play...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Production and characterization of a secreted, C-terminally processed tyrosinase from the filamentous fungus Trichoderma reesei ppt
... Ltd, Chinchester. 12 Lerch K, Huber M, Schneider H, Drexel R & Linzen B (1986) Different origins of metal binding sites in binuclear copper proteins, tyrosinase and hemocyanin. J Inorg Biochem ... Westerholm-Parvinen 1 , Nisse Kalkkinen 2 , Johanna Buchert 1 and Kristiina Kruus 1 1 VTT Technical Research Centre of Finland, Espoo, Finland 2 Protein Chemistry Research Group and...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Cloning and characterization of CBL-CIPK signalling components from a legume (Pisum sativum) ppt
... [7,8]. CBL proteins contain four Ca 2+ -binding EF hand motifs [9] and functions by interacting and regulating a group of Ser ⁄ Thr pro- tein kinases called CBL-interacting protein kinases Keywords abscisic ... calcineurin B-like protein (CBL) and CBL interacting protein kinases (CIPK) are limited to Arabidopsis and rice and their functional role is only beginning to emerge. Here,...
Ngày tải lên: 19/02/2014, 07:20