... activity, thereby providingfurther strength to the < /b> argument that additional mecha-nisms, other than the < /b> inhibition of < /b> NF-jB, account for the< /b> inhibition by dexamethasone. However, the < /b> basis of < /b> ... ligand-binding studies (Fig. 6). It is pos-sible that at these high concentrations RU486 is acting in aGR-independent manner. Notwithstanding the < /b> inhibition athigh doses, it is clear that at ... contrast, the < /b> inhibition of < /b> NF-jB-dependent tran-scription by high c oncentrations of < /b> RU486 correlated v eryclosely, in terms of < /b> both apparent efficacy a nd potency, with the < /b> inhibition of < /b> COX/PGES...