Báo cáo khoa học: "Mutations of p53 Tumor Suppressor Gene in Spontaneous Canine Mammary Tumors" doc

... the p53 gene mutations might be involved in the development of canine mammary tumors and contribute to the prognostic status in canine m ammary carcinomas. Key w ords : dog, mammary tumor, p53 gene ... frameshift mutations in exon 4, 5, 6, and 7 of the p53 gene have been detected in canine mammary Table 2. Mutations in p53 exons 5-8 identified in ca...

Ngày tải lên: 07/08/2014, 15:20

... decrease in the levels of hDlg protein in the human epithelial cell line HeLa when exposed to osmotic shock. This is independent of the phosphorylation state of hDlg, is prevented by preincubating ... guanylate kinase-like region [4]. Functions of hDlg are related to the establishment and maintenance of cell polarity and the adhesion integrity of intestinal epithelial cells [5...

Ngày tải lên: 23/03/2014, 06:20

Ngày tải lên: 07/08/2014, 18:21

... as brain tumors and skin melanomas. To clarify the role of p53 gene, the effect of BNCT on oral squamous cell carcinoma (SCC) cells showing either wild- (SAS/neo) or mutant-type (SAS/mp53) p53 ... h (Figure 6). The protein level of cdc2 increased from 12 h after BNCT, and this was maintained until 48 h. An increase in the phosphorylation of cdc2 occurred at 12 h, indicating cel...

Ngày tải lên: 09/08/2014, 10:20

... role of AP-2a and AP-2e in chondrogenesis. Overview of the differen- tiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of ... helix–span–helix domain at the C-terminus shown in blue medi- ates dimerization and, together with the basic domain, (red) DNA-binding. ‘*’, amino acids that are identical in all seque...

Ngày tải lên: 16/02/2014, 09:20

... consists of a prodo- main, a catalytical domain with a conserved zinc bind- ing sequence, a cysteine-rich disintegrin-like domain, a transmembrane domain and a rather short cytoplasmic domain (Fig. ... mat- uration of the enzyme. Accordingly, the viral delivery of furin into the brain of AD model mice increased a-secretase activity and reduced b-amyloid protein (Ab) production in in...

Ngày tải lên: 16/02/2014, 09:20

... & Barter P (2006) Effect of inhibiting cholesteryl transfer protein on the kinetics of high-density lipoprotein cholesteryl ester transport in plasma: in vivo studies in rabbits. Arterioscl Thromb ... be sufficient to inhibit lysosomal degradation of modified proteins. Interestingly, apoB from oxidized LDL has been shown to accumulate in secondary lysosomes in macrophages be...

Ngày tải lên: 19/02/2014, 02:20

... lines indicate intron 6 of 75 bp in fragments B and C, 3¢ portion of 35 bp in intron 5 in fragments C and D, and 3¢ portion of 25 bp in intron 6 in fragments F and I. The number at the right of ... of alternative promoters in DNASE1 results in no generation of protein isoforms. The 5¢-UTR of eukaryotic mRNA in uences the initi- ation step of protein synthesis an...

Ngày tải lên: 19/02/2014, 06:20

... con- taining DNA spots (5 lg each) corresponding to inter- nal fragments of ADC or cruzipain genes. The latter (used as a control) is a housekeeping gene that encodes the main cysteine proteinase of ... to a-amanitin of the transcription of arginine decarboxylase (ADC) and cruzipain genes in transformed Trypano- soma cruzi. Permeable parasites were preincubated at 0 °C for 5 min...

Ngày tải lên: 19/02/2014, 07:20

... with a linearized plasmid containing a 553-bp fragment of b3Gal-T5 cDNA, that includes the initial 360 bp of the coding sequence and 192 bp of the 5¢ untranslated region of the gene, placed in the ... purification of the included volume of the column in (A), large O-glycans (j), obtained as the included volume of the column in (C), and small O-glycans (s), obtained as the...

Ngày tải lên: 19/02/2014, 12:20