Báo cáo khoa học: "Topology of Scavenger Receptor Class B Type I (SR-BI) on Brush Border Membrane" docx
Báo cáo khoa học: "Topology of Scavenger Receptor Class B Type I (SR-BI) on Brush Border Membrane" docx
... isa functional unit of < /b> SR-BI in rabbit BBMV. Evidence ispresented to show that SR-BI in rabbit BBMV is onlyfunctional when it is part of < /b> a complex which is linked bydisulfide bridges. This ... apo A -I overlay analysis of < /b> rabbitBBMVTo confirm SR-BI in rabbit BBMV, we selected three antiSR-BI antibodies which were raised against differentdomain of < /b> SR-BI (Figure 3) based on predicted ... Compassi, S., Boffelli, D., Werder,Topology of < /b> Scavenger < /b> Receptor < /b> Class < /b> B Type I (SR-BI) on Brush Border Membrane 267ResultsIn vitrotranslation and predicted topology of < /b> rabbitBBMVIn vitro...
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... successively.The immunoreactive bands were visualized using diamino-benzidine (DAB) (Boster Biological Technology, Wuhan,Hubei, China). The following antibodies were used: rabbitSRBI polyclonal antibody ... theexpression of < /b> VSMC differentiation marker genesinduced by all-trans retinoic acid [4]; KLF4 couldinduce inhibition of < /b> proliferation of < /b> VSMC, which ismechanistically linked to a KLF4-induced ... JB (2001) LungKruppel-like factor contains an autoinhibitory domainthat regulates its transcriptional activation by bindingWWP1, an E3 ubiquitin ligase. J Biol Chem 276,29299–29306.25 Ai...
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Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains pptx
... transactivation activity through the repression and associationdomains (or the titration of < /b> co-repressors), resulting in conformational changes from conformation I (or II) into III or IV. In contrast, ... concentration of < /b> GRIP1 might depend on its homo-oligomerization status, which is mainly deter-mined by the involvement of < /b> its C-terminal region inprotein–protein interactions, including self-association,repression ... self-association of < /b> GRIP1 (Figs 1–5), we examined therelationship between transactivation and co-activation of < /b> GRIP1, using a series of < /b> C-truncations to monitorits co-activator functions in the...
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Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines docx
... this effect of < /b> leptin is mediatedby activation of < /b> STAT5.An unexpected finding was the capability of < /b> Tyr1138,which is located within a canonical box3 consensusmotif, to mediate activation of < /b> ... chemilumines-cence using the primary antibodies mentioned above andhorseradish peroxidase-labeled secondary antibody. Blotswere re-used after stripping the primary antibody by incu-bation in ... with asubstitution of < /b> Tyr1141 for phenylalanine or with adeletion of < /b> the C-terminus including Tyr1141 were stillable to induce DNA binding of < /b> overexpressedSTAT 5B in electrophoretic mobility...
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Báo cáo khoa học: Improvement of ecdysone receptor gene switch for applications in plants: Locusta migratoria retinoid X receptor (LmRXR) mutagenesis and optimization of translation start site pptx
... transformation of< /b> ArabidopsisBinary vectors for stable transformation of < /b> Arabidopsis tha-liana were constructed in pCAMBIA2300 vectors (CAM-BIA, Canberra, Australia). To construct the binary vectorfor ... luciferase activity. The plants containing theCfEcR:SHILmRXR switch exhibited low backgroundactivity of < /b> luciferase in the absence of < /b> ligand. On appli-cation of < /b> 16–80 nm methoxyfenozide, the luciferaseactivity ... organ, is valuable for theexpression of < /b> transgenes whose constitutive overexpres-sion is likely to compromise plant viability or fertility.In addition, gene switches are useful to reduce environ-mental...
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
... different constraints on theability of < /b> DNAzymes to hybridize (in comparison withantisense oligonucleotides) because of < /b> the bulky nature of < /b> the activity centre acting as a barrier to accessiblesites ... Downregulation of < /b> urokinase plasminogen acti-vator receptor < /b> expression inhibits Erk signalling withconcomitant suppression of < /b> invasiveness due to loss of< /b> uPAR-beta1 integrin complex in colon cancer ... control. Statistical evaluation showed thatthe effect of < /b> Dz720 in reduction of < /b> uPAR protein concentrations inthe Saos-2 cells was significant as shown by ***P < 0.01.Inhibition of < /b> uPAR by...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... in Fig. 4.Preincubation of < /b> the cells with bikunin during 2 h before100 nMPMA stimulation results in a concentration-depen-dent inhibition of < /b> the induction of < /b> [125 I] DIP-uPA binding(which ... function analysis of < /b> urinary trypsininhibitor (UTI): identification of < /b> binding domains and signalingproperty of < /b> UTI by analysis of < /b> truncated proteins. Biochim.Biophys. Acta 1547, 26–36.29. Fujii, ... bikunin-inducedsuppression of < /b> uPAR expression and ERK activation areshifted towards higher bikunin concentrations in relation tothat for bikunin-induced suppression of < /b> uPA expression.ERK activation is associated...
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Báo cáo khoa học: Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control doc
... (Aurion) at 37 °C. This was followed byincubation with mouse anti-insulin receptor < /b> b- chain mono-clonal antibodies, or anti-IRS1 polyclonal antibodies, orrabbit anti-caveolin polyclonal antibodies ... basalnoninsulin-stimulated conditions, colocalized with theinsulin receptor < /b> in caveolae. In type 2 diabetes the tissuesrespond poorly to insulin, exhibiting insulin resistance thatcan be overcome by increasing ... question of < /b> IRS2localization in these cells. Differential localization of < /b> IRS1and IRS2 could explain why IRS1 is a preferred mediator of< /b> insulin signalling under normal conditions. Receptor < /b> inter-nalization...
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Báo cáo khoa học: Control of nuclear receptor function by local chromatin structure doc
... Transfection experiments with dominantnegative forms of < /b> either BRG1 or BRM have resultedin an inhibition of < /b> transcription, lack of < /b> both Pol IIloading and chromatin transition, as well as compro-mised ... The observed high level of < /b> DNAmethylation within gene bodies and non-coding regionsis believed to serve as a suppressor of < /b> transcriptionalnoise by preventing the spurious transcription initia-tion ... divergent A ⁄ B region con-tains the transcription activation function domain 1(AF1) and is followed by two domains with high degree of < /b> sequence conservation: the DNA binding domain(DBD, region C)...
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Báo cáo khoa học: Effect of ecdysone receptor gene switch ligands on endogenous gene expression in 293 cells docx
... family member-9 (KIF9).The reliability of < /b> microarray results depends on sev-eral factors such as array production, RNA extraction,probe labeling, hybridization conditions and imageanalysis [50–53]. ... lL of < /b> supermix (Bio-RadLaboratories) and 7 lL of < /b> nuclease free water. All theqRT-PCR reactions were performed using the followingreaction conditions: Initial incubation of < /b> 95 °C for 3 minfollowed ... the acid [14], we found that esterifica-tion to the methyl ester followed by controlled brominationwith N-bromosuccinimide and distillation provides pureand plentiful quantities of < /b> 3-bromomethyl-5-methyl...
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