Báo cáo sinh học: "Mechanisms of ubiquitin transfer by the anaphase-promoting complex" pdf
Báo cáo sinh học: "Mechanisms of ubiquitin transfer by the anaphase-promoting complex" pdf
... thioester bond between the active-site cysteine of the E1 and the carboxyl
terminus of ubiquitin. The E1 then transfers the activated ubiquitin to the active-site cysteine of an E2, or ubiquitin- conjugating ...
Finally, the E3, or ubiquitin- protein ligase (green), facilitates the transfer of the ubiquitin from the E2 to a lysine on the target protein...
Báo cáo khoa học: Mechanisms of cholinesterase inhibition by inorganic mercury potx
... affect the folding
of the protein; it may therefore protect the enzyme
from unfolding, due to the binding of two mercury
ions on the same enzyme molecule.
Putative mechanism of inhibition
A goal of ... denaturation (D). This
part of the scheme describes the two phases of inhibi-
tion. To describe the effect of protection by enzyme
concentration, we introduced i...
báo cáo sinh học:" Mobility of primary health care workers in China" pdf
... was rebuilt at the end of the 1990s. Even though
the number of CHCs has increased rapidly over the past
decade, the quality of health care provided by CHCs is a
concern [5]. A lack of both qualified ... on the mobilization of primary health
care workers in China, with the exception of a few papers
looking at mobilization in a single hospital [7,8]. The pur-
pose...
Báo cáo sinh học: " Selection of Recombinant MVA by Rescue of the Essential D4R Gene" doc
...
approach for the generation of recombinant MVA [43,44]. While the BAC technology offers the
advantage of targeting any genomic locus of MVA, the method is dependent on the use of a
helper virus, ... procedure, the absolute titer of the defective virus is
not critical. However, the growth kinetics of dMVA suggest that the expression level of the
vaccinia...
Báo cáo sinh học: " Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR" doc
... contain
the U3 region of an FeLV LTR containing one, two or three
copies of the 21-bp element. The U3 region of the FeLV-A/
61E LTR, containing one copy of the 21-bp element, was
cloned into the ... identified across the
repeat junctions of the 21-bp triplication. Such sites would not occur in the absence of the repeat;
thus, a requirement for c-Myb binding to...
Báo cáo sinh học: " Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription" potx
... both of the other residues yielded the lowest levels
of transcription. These results were in agreement with the
in vitro phosphorylation data and support the hypothesis
that phosphorylation of ... and since the beginning of the
epidemic, 31 million people have died as a result of HIV/
AIDS [3]. One of the major mechanisms employed by the
immune system to countera...
Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx
... systemically, the virus protects the host from
any fatal consequences of the suppression of the immune
system by compensatory enhanced activities of splenic
macrophages and lymphocytes. This cascade of ... reduces the
production of IL-2, IFN and TNF by murine Th1 cells [14]
as well as the IL-12 production by APC [18]. IL-10 may
also, intervene at the level of a...
Báo cáo sinh học: "Conservation of core gene expression in vertebrate tissues" pdf
... not
attempt to align the 94 (of 4,898) ortholog pairs for which
one of the orthologs appears in the intron of another gene.
The motif models input into EEL were the 138 models
returned by JASPAR webserver ... species. The total number of aligned bases in an aligned
conserved element is the sum of counts in each species. TF
genes within the set of unique orthologs...
Báo cáo sinh học: "Adaptations of proteins to cellular and subcellular pH" pdf
... the pH
optimum of stability of monomeric proteins and of their
complexes [10]. This suggests that pH-dependent proper-
ties of the monomers and of the complexes coevolved at
the same pH. The ...
averaged. Their study illustrates the power of quantitative
physicochemical approaches in the analysis of proteomes.
The effectiveness of this approach is also illu...