Báo cáo sinh học : "Exploiting the promiscuity of imatinib" pdf

... structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor. Journal of Biology 2009, 8 8:: 30 Published: 15 ... (CML), in which the chronic phase of the disease is characterized by the increased proliferation of the myeloid lineage and which is cytogenetically diagnosed by...

Ngày tải lên: 06/08/2014, 19:20

... on the pay bill in the first full year of implementation. The absence of a detailed costing by all the trusts, and the absence of a consistent approach to costing, provides one example of the ... limited evaluation of the experience of implementation and of the impact of Agenda for Change. The results of the case study research highlighted variable local...

Ngày tải lên: 18/06/2014, 17:20

... institutions. Outside of the MoH, the Cabinet Office and the Minis- try of Finance control the annual budget for all minis- tries. The Ministry of Education and the Ministry of Science, Technology and ... [http://www.who.int/nha/ country/zmb/Zambia_NH_Strategic_plan,2006-2010%20 .pdf] . 11. Human Resources Crisis in the Zambian Health System: A Call for Urgent Action. [h...

Ngày tải lên: 18/06/2014, 17:20

... The objective of the paper is to contribute to developing a better understanding of workforce stability as a major aspect of the overall policy goal of improved retention of health workers. The ... of workforce stability and methods of monitoring it. The objective of the paper is therefore to contribute to developing a better under- standing of workforce stabilit...

Ngày tải lên: 18/06/2014, 17:20

... point of view of the donor and that of the government. However, there was a certain amount of resistance in the form of a lack of commitment from certain civil service administrators, for whom the ... preparation of decentrali- zation of functions, hampered the attainment of increased equity. Other reasons for failure were cumber- some bureaucracy, loss of staff...

Ngày tải lên: 18/06/2014, 17:20

... Girardi 6 Abstract Introduction: One of the components of the Health Observatory for Latin American and the Caribbean (HO-LAC) is the design and implementation of metrics for human resources for health. Under the HO-LAC ... determine the quantitative dimension of the occurrence of a phenomenon in the field of HRH’. A metric should preferably correspond with some, i...

Ngày tải lên: 18/06/2014, 17:20

... Gilbert D: When kinases meet mathe- matics: the systems biology of MAPK signalling. FEBS Lett 2005, 57 9:1 891-1895. 9. Papin JA, Palsson BO: The JAK-STAT signaling network in the human B-cell: an ... theme described by Zhang et al. [15] corresponds to the between-pathway interpretation of a dense bundle of genetic interactions. On the other hand, the network theme in whic...

Ngày tải lên: 06/08/2014, 18:21

... traits. These predicted missing values influence the right-hand side of the RAM equa- tions, which after canonical transformation is of the form: After each solution of the ... transformation. The other two blocks to solve are: The constraints will be applied on these smaller systems. For example, for the f block, we want to solve: No...

Ngày tải lên: 09/08/2014, 18:22

... than the other two models. Furthermore, the stochastic approach intrinsically takes account of the reduction in selection intensity as compared with the theory, of the relationships ... of the genetic model used for the MC simulations. 4.1. Effect of number of loci Table I presents the values of RV[30] provided by the three models...

Ngày tải lên: 09/08/2014, 18:22

... also the mucous membranes of the throat." Then they mixed all the "stuff" together and sprayed 1 cc of the mixture in each of the nostrils of 10 volunteers, and "into the throat, ... was the largest of the studies, illustrative of the attempts, and remarkable for the courageousness of the volunteers [52]. In 1919 – in a series of exper...

Ngày tải lên: 20/06/2014, 01:20