Báo cáo sinh học: "Dosage compensation is less effective in birds than in mammals" doc

... ratios than A genes. In (b) the panel on the far right shows distributions for brain of individual chromosomes containing more than 50 genes. In all panels in (a) and (b) the rightmost bin (at ... constitutively higher levels in one sex compared with the other. Sex-chromosome dosage compensation is surprisingly ineffective in birds, suggesting that some genomes can do with...

Ngày tải lên: 06/08/2014, 18:21

... and 20 µM indomethacin was added to the culture medium immediately (t = 0 h post binding) or at the indicated times. Cells were maintained in culture medium containing indomethacin until they ... The role of COXs during CoV infection and pathogenesis is not well understood. MHV strain 3, which causes fulminant hepatitis, was shown to induce the synthesis of PGE 2 in macrophages [25]....

Ngày tải lên: 18/06/2014, 18:20

... the other hantaviruses. In terms of coding region, the N protein central region is highly conserved. This region has been shown to contain the RNA binding domain, which in the case of HTN virus has ... a minimal region spanning amino acids 194–204 [10]. Studies of several hantaviruses have implicated the amino- and carboxy-termini in N protein interactions, and although the N protein...

Ngày tải lên: 18/06/2014, 18:20

... proteins by immunoblot assay. F313A contained a change in the amino acid while F 1 313F 2 contained a change in the encoding RNA at the same position but maintained the wild type phenylalanine ... membrane targeting, and this portion would be imbedded in the host membranes. In support of this, we have identified a putative type 2 perox- isome targeting sequence (PTS2) in the N-...

Ngày tải lên: 19/06/2014, 08:20

... (d) DAPI staining of nuclei in the same field as in (c). Nuclear staining is marked by arrowheads (c,d). (e,f) The Ds3 construct, lacking amino acids 334-381, remained in the cytoplasm in the (e) ... for Wnts in morphogenesis and tissue polarity. Nat Cell Biol 2000, 2:E124-E126. 12. Winklbauer R, Medina A, Swain RK, Steinbeisser H: Frizzled-7 signalling controls tissue separation...

Ngày tải lên: 06/08/2014, 18:21

... step and is known to have a role in protection against oxidative stress [11,12]. Confirming this role, G6PDH and 6PGDH enzyme activities have been shown to be maintained in yeast cells during oxidant exposure ... global gene-expression patterns, including trans- cription and translation of genes encoding antioxidants and other metabolic enzymes. It is becoming increasingly recognized,...

Ngày tải lên: 06/08/2014, 18:21

... polymerase, is involved in cytoplasmic polyadenylation in Xenopus oocytes. In this study, a new XGld2-interacting protein was identified: Xenopus RNA-binding motif protein 9 (XRbm9). This RNA-binding ... that are characteristic of RNA-binding proteins, and an alanine-rich carboxy-terminal sequence that could be involved in protein–protein interactions. Interestingly, this alanine-ric...

Ngày tải lên: 07/03/2014, 05:20

... medical doctors are important in the existing relationship between the two categories. " Something very important is missing in the TC profile and it is the training itself that is failing, ... difficulties in retaining medical doc- tors in rural areas and the brain drain from low-income to high-income countries has renewed the interest in look- ing at alternatives of p...

Ngày tải lên: 18/06/2014, 17:20

... strategies into systems and practices that result in sustainable improvements. At the beginning of this piece, HR manag- ers who were uninspired concerning their ability to bring about these kinds ... professionals before lasting change can occur. ▪ Key stakeholders, especially outside the health sector, are not involved Ministries of health cannot solve the HR crisis on their own. Minist...

Ngày tải lên: 18/06/2014, 17:20

... work for the districts in these provinces is based on information available in the annual district health sector report and discussions with senior adminis- trators in the district health office. Results The ... impor- tance for midwives (nine districts had more than one third of their midwives employed on this basis) and of declining importance for doctors. Nurses were not included...

Ngày tải lên: 18/06/2014, 17:20