Báo cáo sinh học: "Dimerization in protein kinase signaling" ppsx

... marrow kinase in chromosome X BTK - Bruton’s tyrosine kinase FAK - Focal adhesion kinase ITK - T cell specific kinase Pyk2 - Protein- tyrosine kinase 2 Syk - Spleen tyrosine kinase TEC - Tec protein- tyrosine ... kinase TEC - Tec protein- tyrosine kinase ZAP70 - 70 kDa zeta T chain-associated kinase Non-receptor protein- serine/threonine kinases • Doubled catalytic dom...

Ngày tải lên: 06/08/2014, 18:21

... they would be in a paper in which they were explored in more depth and in which the individual hypothesis-driven experiments could be sum- marized. For instance, a paper we published in Journal ... although contributing some human interest, may be a poor investment of resources, making papers unnecessarily long, delaying the entry of valuable reagents and datasets into the public do...

Ngày tải lên: 06/08/2014, 18:21

... protein kinase C, Ca 2+ /calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing ... factors, cytokines, neurotransmitters, adhesion molecules, drugs, and physical stimuli [2]. Pathways leading to PLD activation include protein serine/threonine kinases, e.g. prote...

Ngày tải lên: 16/03/2014, 16:20

... blebbing through tropomyosin phosphorylation. However, DAPK is not the only kinase exerting its inhibitory effects on blebbing via tropomyosin. Indeed, DAPK is insensitive to the kinase inhibitor ... moesin (ERM) family of actin–membrane linker proteins or by being chelated by myristoylated alanine-rich C kinase sub- strate [24]. Delamination from the actin cortex is observed in filami...

Ngày tải lên: 29/03/2014, 08:20

... death-associated protein kinase (DAPK) in the regulation of autophagy is particularly interesting. DAPK is a serine ⁄ threonine kinase originally isolated by a genetic screening for positive mediators of interferon-c-induced ... C, Lin Y, Harrison B, Burch L, Ridgway RA, Sansom O & Hupp T (2009) Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase...

Ngày tải lên: 29/03/2014, 08:20

... Sciences, Faculty of Medicine, University of Glasgow, UK Introduction Death-associated protein kinase (DAPK) is a cal- cium ⁄ calmodulin-regulated serine ⁄ threonine protein kinase, located on chromosome ... revealed that DAPK protein was inactive, sug- gesting that the kinase activity of DAPK was inacti- vated in cancer cells [38]. Our own studies assessing protein expression...

Ngày tải lên: 29/03/2014, 08:20

... expression in calnexin-containing but not in calnexin-deficient cellsFigure 2 HPV16 E5 decreases HLA-I surface expression in calnexin-containing but not in calnexin-deficient cells. CEM-C7 (calnexin) ... suggesting that this binding might be involved in HLA-I down-regulation. Nevertheless, our results point to the binding of E5 to cal- nexin as the critical molecular event directly...

Ngày tải lên: 18/06/2014, 18:20

... usage of VX-680 inhibition of Aurora kinase in ATRA-resistant APL remains unknown. Here we showed that Aurora kinase small-molecule inhibitor VX-680 led to mitotic defects in spindle and decreased ... assessing the sub-G1 population (Figure 4B). In addition, apoptotic cells were also detected by both Annexin V/PI staining and immunofluorescent staining with Hoechst 33342. Annexin V/...

Ngày tải lên: 18/06/2014, 19:20

... CRC carcinogenesis [37]. There- fore, early during CRC carcinogenesis, an effect ive cyto- toxic effect induced by 5-FU in the KIAA0247- expressing cells could be crucial in controlling the G2/ M ... inactivates the G2/ M checkpoint leading to tumor cell death [24]. When testing the cDNA fr om mu ltiple tissues, KIAA0247 expression was highest in PBL and at various levels in gastroint...

Ngày tải lên: 18/06/2014, 19:20

... protein kinase; MAPKK, mitogen-activated protein kinase kinase; MBP, myelin basic protein; OXI1, oxidative signal-inducible 1; PDK1, 3-phosphoinositide-dependent kinase 1; PTI1, Pto-interacting ... two proteins was confirmed by in vivo co-immunoprecipitation experiments. We then examined how both proteins interact with MPK3 and MPK6 proteins. Results AGC kinases interact with PTI1...

Ngày tải lên: 14/02/2014, 19:20