Báo cáo sinh học: "Roughing up Smoothened: chemical modulators of Hedgehog signaling" potx

... 2002, 1:8 Minireview Roughing up Smoothened: chemical modulators of Hedgehog signaling Randall W King Address: Institute of Chemistry and Cell Biology, Department of Cell Biology, Harvard Medical ... addition of Shh protein. Screening of 140,000 compounds for the ability to activate luciferase expression in the absence of Shh protein led to the identification of the le...

Ngày tải lên: 06/08/2014, 18:20

... and 9.21). In the off- site group two hospitals could not manage a score of >10 (7.50 and 8.67). Figure 4 provides a graphic depiction of the distribution of the scores of individual hospitals ... impor- tance of these other factors still needs to be tested. Five hospitals, three in Group A and two in Group B, failed to achieve evidence of practice. The one that failed Performa...

Ngày tải lên: 18/06/2014, 17:20

... a team of Egyptian consultants to design the contents of the LDP. AES led the scale -up process of the LDP in Aswan- including the adaptation of local training materials and development of 35 local ... Swesy 2 Abstract Introduction: In 2002, the Egypt Ministry of Health and Population faced the challenge of improving access to and quality of services in rural Upper Egypt in t...

Ngày tải lên: 18/06/2014, 17:20

... strain 6BC, the chemical structures of which are already known [12,13]. The negative ion MALDI-TOF mass spectrum of the native LPS (Fig. 1) exhibited a complex pattern of several groups of ion peaks ... of laser-induced fragment ions [18] representing the lipid A moiety of LPS (centered around m/z 1850, 1641, and 1347). The mass difference of D m/z 660 between the respective g...

Ngày tải lên: 20/02/2014, 23:20

... Therefore, it is possible that cofactors bind to their corresponding polypeptides before or during folding in vivo. Cofactors most often stabilize the native states of the proteins with which they interact ... determine the origin of thermostability in monomeric proteins (most often without cofactors) have led to several hypotheses, such as stabiliza- tion by an increased number of ioni...

Ngày tải lên: 16/03/2014, 23:20

... of centers of public health, and b) qual- itative study – Focus Group Discussions (FGD) of selected professionals. From September to November 2004, 30 randomly selected, local CPH (of total of ... Human resources (HR) are one of the most important components determining performance of public health system. The aim of this study was to assess adequacy of HR of local public h...

Ngày tải lên: 18/06/2014, 17:20

... and therefore periods of support should con- tinue beyond this. Evidence from the US [42] suggests that extending the mandatory period of support is a successful way of supporting newly qualified ... Interface Notice of off duty Combining work hours with social life Frequency with which I leave work on time Resources Adult and Child Availability of equipment(e.g. hoists) Availabilit...

Ngày tải lên: 18/06/2014, 17:20

... Distribution of health workers relative to population and alternative indicators of health care needs District level data (113 districts) Measures of need Share of population Share of U5 deaths Share of ... clear graphical illustration of the importance of alternative indicators of health care needs for the measurement of health worker distributional inequalities. Moreover...

Ngày tải lên: 18/06/2014, 17:20

... on the advice of one of the authors (PF), an expert in the field of maternal health and EmOC, the search strat- egy was supplemented by a systematic review of the table of contents of specific ... per- ceptions of the quality of care. This is reported in Tanzania in 2003, where the low rate of utilization of health centres providing EmOC is partially due to the poor percep...

Ngày tải lên: 18/06/2014, 17:20

... significance of the courses in terms of potential application and organi- zational impact. Generally, the results tallied with that of the first level of enquiry, i.e. the higher the usefulness of the ... satis- Importance of ways of learning about health planning and managementFigure 1 Importance of ways of learning about health planning and management. 0.0 0.5 1.0 1.5 2.0...

Ngày tải lên: 18/06/2014, 17:20