Nicotinic acetylcholine receptors potx

Nicotinic acetylcholine receptors potx

... sites of expression: muscle-type nicotinic receptors and neuronal-type nicotinic receptors. In the muscle-type receptors, found at the neuromuscular junction, receptors are either the embryonic ... receptors, glycine receptors, and the type 3 serotonin receptors (which are all ionotropic receptors) , or the signature Cys-loop proteins. Nicotinic receptors are broadly clas...

Ngày tải lên : 29/07/2014, 00:20

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Báo cáo khoa học: Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors potx

... were 200 pm (for M 1 ,M 3 and M 5 receptors) or 500 pm (for M 2 and M 4 receptors) , in the presence of 5 lm (M 1 ,M 3 and M 5 receptors) or 50 lm (M 2 and M 4 receptors) of GDP. Nonspeciﬁc binding ... selectivity for subtypes of muscarinic acetylcholine receptors. Biochi- mie 82, 793–806. 3 Nirthanan S & Gwee MC (2004) Three-ﬁnger alpha- neurotoxins and the nicotinic acetylchol...

Ngày tải lên : 23/03/2014, 05:22

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Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt

... (2002) Nicotinic acetylcholine receptors and epi- lepsy. Curr. Drug Target CNS Neurol. Disord. 1, 443–448. 10. Sciamanna, M.A., Griesmann, G.E., Williams, C.L. & Lennon, V.A. (1997) Nicotinic acetylcholine ... neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr. Drug Target CNS Neurol. Disord. 1, 399–411. 8. Geerts, H., Finkel, L., Carr,...

Ngày tải lên : 19/02/2014, 12:20

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Tài liệu Báo cáo khoa học: A synthetic weak neurotoxin binds with low afﬁnity to Torpedo and chicken a7 nicotinic acetylcholine receptors docx

... that natural weak neurotoxins from cobras have poor affinity for nicotinic acetylcholine receptors. Keywords: snake neurotoxins; nicotinic acetylcholine receptors. During the past three decades, the most ÔobviousÕ ... small proteins with five disulfide bonds, which have been shown to be poor binders of nicotinic acetylcholine receptors. We report on the cloning and sequencing of...

Ngày tải lên : 21/02/2014, 03:20

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Báo cáo khoa học: Novel a-conotoxins from Conus spurius and the a-conotoxin EI share high-afﬁnity potentiation and low-afﬁnity inhibition of nicotinic acetylcholine receptors doc

... drugs. Abbreviations a 1 b 1 cd, muscular nicotinic acetylcholine receptor; a 3 b 4 , peripheral nervous system nicotinic acetylcholine receptor; a 4 b 2 , central nervous system nicotinic acetylcholine receptor; ... selectivity of a-conotoxin MI for nicotinic acetylcholine receptors. Biochemistry 38, 13310–13315. 23 Dutton JL & Craik DJ (2001) a-Conotoxins: nicotinic...

Ngày tải lên : 16/03/2014, 11:20

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Báo cáo khoa học: a-Conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californicaand some neuronal subtypes of nicotinic acetylcholine receptors pdf

... domain of nicotinic receptors. Nature 411, 269– 276. 17 Celie PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB & Sixma TK (2004) Nicotine and carba- mylcholine binding to nicotinic acetylcholine ... have become widely used tools in studies on nicotinic acetylcholine receptors (nAChRs) [6,7] because they can distinguish between different nicotinic acetylcholine rec...

Ngày tải lên : 16/03/2014, 13:20

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Tài liệu Báo cáo khoa học: Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 ppt

... desensiti- zation of acetylcholine receptors. Proc R Soc Lond B 209, 447–452. 35 Barnard EA, Miledi R & Sumikawa K (1982) Transla- tion of exogenous messenger RNA coding for nicotinic acetylcholine receptors ... a–c and a–d subunit interfaces of the nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 87, 2785–2789. 6 Grutter T & Changeux JP (2001) Nicotinic recept...

Ngày tải lên : 19/02/2014, 07:20

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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

... neuronal nicotinic acetylcholine receptor subtypes; pharmacology; venom peptides; Xenopus oocytes. Neuronal nicotinic acetylcholine receptors The nicotinic acetylcholine receptor family The nicotinic ... structure of a receptor. The nicotinic acetylcholine receptor. Eur. J. Biochem. 239, 539–557. 8. Karlin, A. (2002) Emerging structure of the nicotinic acetylcholine r...

Ngày tải lên : 19/02/2014, 12:20

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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx

... interaction with cognate G proteins. As both bradykinin receptors coupled to the same G a subunit G q ⁄ 11 the different IP responses obtained with the wild-type receptors and the chimera let us speculate ... provided that the new chimeric receptors have an intact ⁄ homogeneous helix 8 either from B 2 wt or B 1 wt or a chimeric B 1 ⁄ B 2 helix with a conserved V323. Chimeric receptors...

Ngày tải lên : 07/03/2014, 16:20

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