Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P46 docx

... tissue Index G.S. Lynch (ed.), Sarcopenia – Age-Related Muscle Wasting and Weakness, DOI 10.1007/978-90-481-9713-2, © Springer Science+Business Media B.V. 2011 470 J.G. Ryall and G.S. Lynch Ryall, J. ... Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia. The Journals of Gerontology. Series...

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... USA

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... attenuate, prevent, and potentially reverse age-related muscle wasting and weakness. 3 Overview of Our Current Understanding of the Cellular and Molecular Mechanisms Underlying Sarcopenia Several ... resource for understanding all of the signalling pathways implicated in age-related muscle wasting and weakness and describing the comprehensive list of drugs and ap...

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... combat sarcopenia age-related muscle wasting and weakness. Internal Medicine Journal, 34, 294–296. Lynch, G. S. (2004b). Emerging drugs for sarcopenia: age-related muscle wasting. Expert Opinion ... A., Giorgino, F. (2010). The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosi...

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... 2 1Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia 3.3 Age-Related Muscle Wasting: Mechanisms Despite numerous theories and intensive research, the principal ... onset of age-related disease and disabilities depend on solid funda- mental scientific knowledge and a detailed mechanistic insight. Some of the mechanisms and determinants involved in muscl...

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... −8 and −9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia. British Journal of Cancer, 84, 1135–1140. 3 5Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia Warren, ... shortening TNF-a IGF-1 IGF-1 MUSCLE ATROPHY MUSCLE MASS MUSCLE STRENGTH SARCOPENIA MUSCLE WEAKNESS MOBILITY SATELLITE CELLS Fig. 9 Role of cytokines in myofiber...

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... type IIx and/ or IIb fibers (Prakash and Sieck 1998; Mantilla et al. 2004; Prakash et al. 1995, 1996b; Sieck and Prakash 1997). 37 G.S. Lynch (ed.), Sarcopenia – Age-Related Muscle Wasting and Weakness, ... influences (Vandervoort 2002; Delbono 2003). The effects of age-related inactivity, motor neuron loss and sarcopenia all depend on motor unit and/ or muscle fi...

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... amplitude and quantal content are limited to limb muscles and do not reflect a general response across all muscles. An age-related decrease in cross-sectional area, in particular at type IIx and/ or ... hindlimb muscles from young and aged rats. Mechanisms of Ageing and Development, 125, 619–627. Lowe, D. A., Warren, G. L., Snow, L. M., Thompson, L. V., Thomas, D. D. (2004b)....

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... proposed by Krnjevic’ and Miledi (1958) and successfully used first by Edström and Kugelberg (1968), Burke et al. (1971), Brandstater and Lambert (1969, 1973), and Doyle and Mayer (1969). After ... the elasticity of the muscle and the muscle tendons, patterns of motor unit recruitment, and activation of antagonist muscles. Single fiber preparations, on the other hand,...

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... in the field of skeletal muscle physiology to probe previously unexplored domains of muscle proteins, and to test and refine molecular models of muscle structure and function (reviewed in ... with a change in muscle strength is an alteration in muscle mass. 3 Age-Related Changes in Contractility Aging is associated with a progressive decline of muscle mass, strength, a...

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