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... tissue
Index
G.S. Lynch (ed.), Sarcopenia – Age-Related Muscle Wasting and Weakness,
DOI 10.1007/978-90-481-9713-2, © Springer Science+Business Media B.V. 2011
470 J.G. Ryall and G.S. Lynch
Ryall, J. ... Attenuation of age-related muscle wasting
and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia.
The Journals of Gerontology. Series...
Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P2 ppt
... attenuate, prevent, and potentially reverse age-related muscle
wasting and weakness.
3 Overview of Our Current Understanding of the Cellular
and Molecular Mechanisms Underlying Sarcopenia
Several ...
resource for understanding all of the signalling pathways implicated in age-related
muscle wasting and weakness and describing the comprehensive list of drugs and
ap...
Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P3 pptx
... combat
sarcopenia age-related muscle wasting and weakness. Internal Medicine Journal, 34,
294–296.
Lynch, G. S. (2004b). Emerging drugs for sarcopenia: age-related muscle wasting. Expert Opinion ... A., Giorgino, F. (2010). The
GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying
age-related skeletal muscle wasting and osteoporosi...
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... 2 1Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia
3.3 Age-Related Muscle Wasting: Mechanisms
Despite numerous theories and intensive research, the principal ... onset of age-related disease and disabilities depend on solid funda-
mental scientific knowledge and a detailed mechanistic insight.
Some of the mechanisms and determinants involved in muscl...
Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P5 ppsx
... −8 and −9
substrates by proteases in skeletal muscles from mice undergoing cancer cachexia. British
Journal of Cancer, 84, 1135–1140.
3 5Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia
Warren, ... shortening
TNF-a
IGF-1
IGF-1
MUSCLE ATROPHY
MUSCLE MASS
MUSCLE STRENGTH
SARCOPENIA
MUSCLE WEAKNESS
MOBILITY
SATELLITE CELLS
Fig. 9 Role of cytokines in myofiber...
Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P6 ppt
... type IIx and/ or IIb fibers (Prakash and Sieck
1998; Mantilla et al. 2004; Prakash et al. 1995, 1996b; Sieck and Prakash 1997).
37
G.S. Lynch (ed.), Sarcopenia – Age-Related Muscle Wasting and Weakness, ... influences (Vandervoort
2002; Delbono 2003). The effects of age-related inactivity, motor neuron loss and
sarcopenia all depend on motor unit and/ or muscle fi...
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...
amplitude and quantal content are limited to limb muscles and do not reflect a
general response across all muscles.
An age-related decrease in cross-sectional area, in particular at type IIx and/ or ... hindlimb muscles from young and aged rats. Mechanisms of Ageing and
Development, 125, 619–627.
Lowe, D. A., Warren, G. L., Snow, L. M., Thompson, L. V., Thomas, D. D. (2004b)....
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...
proposed by Krnjevic’ and Miledi (1958) and successfully used first by Edström
and Kugelberg (1968), Burke et al. (1971), Brandstater and Lambert (1969, 1973),
and Doyle and Mayer (1969). After ... the elasticity of the muscle and the muscle tendons, patterns
of motor unit recruitment, and activation of antagonist muscles. Single fiber
preparations, on the other hand,...
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... in the
field of skeletal muscle physiology to probe previously unexplored domains of
muscle proteins, and to test and refine molecular models of muscle structure and
function (reviewed in ... with a change in muscle
strength is an alteration in muscle mass.
3 Age-Related Changes in Contractility
Aging is associated with a progressive decline of muscle mass, strength, a...