Neurochemical Mechanisms in Disease P69 potx

... activity (Frederickson, 1989) or by conferring structural stability to Zn finger domains of DNA binding proteins (Colvin et al., 2003) including stimulating protein-1 (sp-1), a transcription factor responsible ... alterations of zinc (Zn) in the brain in Alzheimer’s disease (AD), although the potential fole of these alterations in the pathogenesis of AD remains unclear. The following e...

Ngày tải lên: 07/07/2014, 09:20

... three or four tubulin-binding domains, Grey boxes: inserts from exon 2 near the N-terminus, Vertical lines in boxes: inserts from exon 3 near the N-terminus, and Black boxes: inserts from exon ... deposits in the parenchyma, indicating that BACE1 is in tight control of the balance in amyloid pathology in brain, promoting either parenchyma or vasculature. APP/ApoE Mice In epidemiol...

Ngày tải lên: 07/07/2014, 09:20

... Brain Edema 133 6 Role of Aquaporins in Brain Edema 134 7 Injury Cascade in Brain Edema: Molecular Mechanisms 136 7.1 Cation Channels Involved in Cytotoxic Edema 137 7.2 Role of MMPs in the ... sulfate, and binding sites on the laminin and fibronectin molecules (Zlokovic, 2008). Within the basal lamina reside the pericytes (Fig. 1). Mesenchymal in origin, pericytes form an incom...

Ngày tải lên: 07/07/2014, 09:20

... Orientation in PD 256 6.2 Aging and Cognitive Event-Related Potentials 259 6.3 Neurotransmitters and Cognitive ERP-S in PD 259 6.4 Dopamine in Visual Processing in the Retina 260 6.5 Retinal Model ... emphasized in relation to visuocogntive and attentive dysfunction. The main neurotransmitter systems involved are dopamine (in PD) and acetyl- choline (both in PD and AD). The l...

Ngày tải lên: 07/07/2014, 09:20

... aligned according to ankyrin repeats. The amino-terminal signal response domain (SRD) and the carboxyl-terminal acidic region rich in prolines, glutamates, serines, and threonines (PEST) are indicated. ... NF-κB in Brain Diseases 297 Interestingly, two larger proteins, p105 (also called NF-κB1) and p100 (NF-κB2), contain the Rel homology region of p50 and p52 in their amino-terminal hal...

Ngày tải lên: 07/07/2014, 09:20

... Trinucleotide Expansion—Polyglutamine (Q n )-Expansion Diseases Ten CAG-expansion diseases are currently known. In nine of these diseases (listed in Table 2), the mutation occurs in an exon (coding region) and results in an ... findings suggest a toxic gain of function in the mutated SBMA. Androgens are important in regulating sexually dimorphic neurons in the rat brain. They are...

Ngày tải lên: 07/07/2014, 09:20

... acetylcholinesterase inhibitors including donepezil, rivastigmine, and galantamine have shown some promise in treating symptoms of autism. Interestingly, both donepezil and galan- tamine are effective in improving prepulse ... demonstrating reduced [ 3 H]epibatidine binding to α 4 and β 2 receptor subunits and reduced α 4 subunit mRNA in parietal cortex and increased α 7 binding and red...

Ngày tải lên: 07/07/2014, 09:20

... Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438:71–75 Tseng LF, Collins KA (1993) Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventriculary ... oxytocin-stained and neurophysin-stained fibers in the spinal-cord of the rat and monkey. J Comp Neurol 188:87–106 Sweeney MI, White TD, Sawynok J (1987) Involvement...

Ngày tải lên: 07/07/2014, 09:20

... M, Gwinn-Hardy K, Cookson MR, Singleton AB (2004) Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 62:1835–1838 Mineur YS, McLoughlin D, ... gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Nat Genet 23:47–51 Sandbrink R, Masters CL, Beyreuther K (1994) Similar alternative splicing of a non-homologous domain in b...

Ngày tải lên: 07/07/2014, 09:20

... 299–301 in brain diseases, 307 domains, 298 in glial cells, 306 in Huntington’s disease (HD), 309–310 inhibitors, 297 in ischemic and traumatic brain injury, 307–308 in learning and memory, 305 in ... 364 Receptor-interacting kinase-1 (RIP1), 24 Reelin, 392 Rel family, 297 polypeptides, 301 Remyelination, in MS, 545 Renin-angiotensin system (RAS), 444 Retina, 250, 260 dopamine...

Ngày tải lên: 07/07/2014, 09:20