Neurochemical Mechanisms in Disease P43 pptx
Neurochemical Mechanisms in Disease P43 pptx
... repeat in FMR1 causes FXTAS, which is characterized by intention tremor, Parkinsonism, cognitive decline, and neuropathy (Hagerman and Hagerman, 2004). In FXTAS, CGG-binding proteins including hnRNP ... muscleblind proteins and deregulated alternative splicing in neurons. Hum Mol Genet 13:3079–3088 Kashima T, Rao N, Manley JL (2007) An intronic element contributes to splicing repression...
Ngày tải lên: 07/07/2014, 09:20
Neurochemical Mechanisms in Disease P9 pptx
... in the Parkin Gene (PARK2) The parkin gene, which maps to chromosome 6, encodes a 465 amino acid pro- tein containing an N-terminal ubiquitin-like domain, a central linker region, and C-terminal ... and a serine–threonine protein kinase domain. Most reported mutations were distributed throughout the serine–threonine protein kinase domain. Thus, loss of function of kinase activity of PINK1 i...
Ngày tải lên: 07/07/2014, 09:20
Neurochemical Mechanisms in Disease P20 pptx
... Repeated cocaine use has been shown to increase DAT activity in humans (Mash et al., 2002). The ini- tial increase in extracellular dopamine after cocaine administration is thought to result in increased ... GABA B receptor agonist, has resulted in increased cocaine abstinence in cocaine-addicted patients (Shoptaw et al., 2003). Similarly, the GABA transporter inhibitor tiagabine th...
Ngày tải lên: 07/07/2014, 09:20
Neurochemical Mechanisms in Disease P25 pptx
... plextrin homology (PH) domains, it contains an N-terminally located calponin homology (CH) domain, an SH3 domain, a GIT binding domain, and a C-terminally located leucine zipper that mediates the formation ... Lowe-syndrome patients, in addition to increased PI(4,5)P 2 levels, also had alterations in the actin cytoskeleton, an increased sensitivity to actin depolymerizing agents, and misl...
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Neurochemical Mechanisms in Disease P42 pptx
... 3 end of an intron to form a spliceosome complex E (Sperling et al., 2008). SF1, a 75 kDa protein, is a mammalian homologue of yeast BBP (branch point-binding protein). U2AF65 and U2AF35 bring U2 ... families. Invest Clin 33:13–31 Moreno-Fuenmayor H, Borjas L, Arrieta A, Valera V, Socorro-Candanoza L (1996) Plasma excitatory amino acids in autism. Invest Clin 37:113–128 Narayan M, Srinath...
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Neurochemical Mechanisms in Disease P51 pptx
... the involvement of a descending cholinergic pathway in systemic morphine analgesia. Brain Res 478:293–300 Chiari A, Eisenach JC (1999) Intrathecal adenosine: interactions with spinal clonidine ... Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain 86:11–18 Barke KE, Hough LB (1993) Simultaneous measurement of opiate-induced histamine release...
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Neurochemical Mechanisms in Disease P58 pptx
... Factors Involved in Myelination and Demyelination in the CNS 4.1 Astrocytes and Mutations in GFAP Alexander disease (AxD) is a leukodystrophy caused by dominant mutations in GFAP, the main intermediate ... lipid-binding proteins. Unlike other myelin proteins, its quantitative expression varies greatly according to species, ranging from less than 1% in rodent sciatic nerves up to 5...
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Neurochemical Mechanisms in Disease P79 pptx
... convincingly implicate nAChRs in the etiology of autism. Therefore, the relevance of the altered expression of nAChRs in this disease remains to be determined. Nicotinic Receptors in Brain Diseases ... Perry EK (2000) Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease and in...
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Neurochemical Mechanisms in Disease P86 pps
... 299–301 in brain diseases, 307 domains, 298 in glial cells, 306 in Huntington’s disease (HD), 309–310 inhibitors, 297 in ischemic and traumatic brain injury, 307–308 in learning and memory, 305 in ... 364 Receptor-interacting kinase-1 (RIP1), 24 Reelin, 392 Rel family, 297 polypeptides, 301 Remyelination, in MS, 545 Renin-angiotensin system (RAS), 444 Retina, 250, 260 dopamine...
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Neurochemical Mechanisms in Disease P1 ppsx
... material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Contents Mechanisms Versus Diagnoses 1 John P. Blass Molecular Mechanisms ... Neurodegenerative Disorders: Parkinson’s Disease and Alzheimer’s Disease 243 Ivan Bodis-Wollner and Herman Moreno NF-κB in Brain Diseases 293 Cheng-Xin Gong Trinucleotide-Expansion D...
Ngày tải lên: 07/07/2014, 09:20