Neurochemical Mechanisms in Disease P16 pot
MECHANISMS IN PARKINSON’S DISEASE – MODELS AND TREATMENTS pot
... dressing, feeding, bathing, getting out of chairs, and turning in bed. Constipation, chewing and swallowing difficulties, drooling of saliva, and urge incontinence of urine are common complaints. ... Parkinson’s disease drugs; increase water and salt intake; fludrocortisone, ephedrine, or midodrine Drooling 0-5% atropine eye drops sublingually, scopoderm patch, or botulinum toxin in...
Ngày tải lên: 27/06/2014, 13:20
Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
... tissue staining intensities influ- enced the measured values. Average value density measurements from individual Vgf immunoreactive dorsal spinal cord neurons, reflecting immunostaining intensity, ... dys- function/degeneration resulting in abnormal energy metabolism are important factors in the evolution of the disease in several SOD-1 mutant mouse models of ALS, including...
Ngày tải lên: 03/11/2012, 10:52
Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot
... recognition in the normal splicing process [55]. First, U1snRNP binding to an intronic splicing processing element has been found to inhibit pathological pseudoexon inclusion in intron 20 of ... splice- supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (C...
Ngày tải lên: 06/03/2014, 09:22
Báo cáo khoa học: Functional analysis of disease-causing mutations in human galactokinase potx
... also affects the binding of galactose at some point in the reaction. Modest changes in K m,ATP are seen in H44Y and R68C. That H44 in uences the binding of both substrates suggests that the binding sites ... 2003 homoserine kinase, proton transfer is unlikely to play a major role in the rate-determining step of catalysis. Several of the disease- causing mutations are not soluble fol...
Ngày tải lên: 08/03/2014, 02:20
Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
... shown to bind to and inhibit the ser- ine–threonine protein phosphatase calcineurin [5]. The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is highly ... data from other studies showing decreased calcineurin activ- ity in AD, and other data showing that calcineurin inhibition results in tau phosphorylation on serine and threonine resid...
Ngày tải lên: 16/03/2014, 11:20
Báo cáo khoa học: Molecular mechanisms in successful peripheral regeneration pot
... Giannakopoulos P, Srinivasan A & Dubois-Dauphin M (2000) In vivo study of motoneuron death induced by nerve injury in mice deficient in the caspase 1 ⁄ interleukin-1 beta-converting enzyme. Neu- roscience ... metabolism and protein synthesis [43,44] resulting in polyamines such as putrescine, spermine and spermidine show a strong enhancing effect on neurite outgrowth both in vitr...
Ngày tải lên: 30/03/2014, 16:20