Chapter 103 Polycythemia Vera and Other Myeloproliferative Diseases (Part 8) potx

... recognized because we currently lack adequate diagnostic tools. Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 8) Chronic Idiopathic Myelofibrosis: Treatment No specific ... to distinguish ET from the other chronic myeloproliferative disorders, which may also present with thrombocytosis but have differing prognoses and therapy (Ta...

Ngày tải lên: 07/07/2014, 04:20

... agents. This chapter, therefore, will focus only on PV, IMF, and ET, because their clinical overlap is substantial and their clinical courses are distinctly different. Other chronic myeloproliferative ... different. Other chronic myeloproliferative disorders will be discussed in Chapter 104. Polycythemia Vera Polycythemia vera (PV) is a clonal disorder involving a...

Ngày tải lên: 07/07/2014, 04:20

... polycythaemia vera and apparent polycythaemia. Br J Haematol 129:701, 2005 Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 10) Complications Perhaps no other condition ... al: Thrombosis and hemorrhage in polycythemia vera and essential thrombocythaemia. Br J Haematol 128:275, 2005 Levine RL, Gilliland DG: JAK- 2 mutations an...

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... Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 2) Etiology The etiology of PV is unknown. Although nonrandom chromosome abnormalities ... family and serves as the cognate tyrosine kinase for the erythropoietin and thrombopoietin receptors. It also functions as an obligate chaperone for these receptors in the Golgi apparatus and ... e...

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... fibromyoma Adrenal tumors Meningioma Pheochromocytoma Drugs Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 3) Diagnosis When PV presents with erythrocytosis ... previous hemoglobin levels and a family study are important. Other laboratory studies that may aid in diagnosis include the red cell count, mean corpuscular volume, and...

Ngày tải lên: 07/07/2014, 04:20

... hematopoiesis. Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 5) Chronic Idiopathic Myelofibrosis Chronic IMF (other designations include agnogenic myeloid ... myelofibrosis and splenomegaly are also features of both PV and CML. Furthermore, myelofibrosis and splenomegaly also occur in a variety of benign and malignant disorders...

Ngày tải lên: 07/07/2014, 04:20

... myeloblasts, older Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 6) Figure 103- 2 age, the presence of complex cytogenetic abnormalities, and constitutional ... thrombocytosis with large and bizarre platelets, and circulating myelocytes suggests the presence of a myeloproliferative disorder as opposed to a secondary form of...

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... Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 7) Table 103- 4 Risk Stratification for Idiopathic Myelofibrosis

Ngày tải lên: 07/07/2014, 04:20

... IMF and PV have also been observed in some kindreds. Clinical Features Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 9) Etiology Megakaryocytopoiesis and ... patients, and by the expression in patients of nonrandom, though variable, cytogenetic abnormalities. Although thrombocytosis is its principal manifestation, like the other c...

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... gluconate (Ferrlecit) and iron sucrose (Venofer), that have a much lower rate of adverse effects. Chapter 098. Iron Deficiency and Other Hypoproliferative Anemias (Part 8) Of the complications ... use has been rising rapidly in the last several years with the recognition that recombinant erythropoietin therapy induces a large demand for iron—a demand that frequently can...

Ngày tải lên: 07/07/2014, 04:20