Chapter 110 Coagulation Disorders (Part 4) potx

... tapered depending on the extent of the surgical wounds. Oral surgery is Chapter 110. Coagulation Disorders (Part 4) Factor VIII and Factor IX are dosed in units. One unit is by definition

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... deficiencies of plasma coagulation are more frequent than congenital disorders; the most common disorders include hemorrhagic diathesis of liver disease, disseminated intravascular coagulation (DIC), ... disease, disseminated intravascular coagulation (DIC), and vitamin K deficiency. In these disorders, blood coagulation is hampered by the deficiency of more than one clotting...

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... 1 1–14 d Chapter 110. Coagulation Disorders (Part 1) Harrison's Internal Medicine > Chapter 110. Coagulation Disorders Coagulation Disorders: Introduction Deficiencies of coagulation ... bleeding disorders due to deficiencies of other factors, including FII (prothrombin), FV, FVII, FX, FXI, FXIII, and fibrinogen are usually inherited in an autosomal...

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... Chapter 110. Coagulation Disorders (Part 3) Clinically, hemophilia A and hemophilia B are indistinguishable. The ... after major trauma or during routine presurgery laboratory tests. Typically, the global tests of coagulation show only an isolated prolongation of the aPTT assay. Patients with hemophilia have

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... Chapter 110. Coagulation Disorders (Part 6) Factor XI Deficiency: Treatment The treatment of FXI deficiency is ... therapy. Other Rare Bleeding Disorders Collectively, the inherited disorders resulting from deficiencies of clotting factors other than FVIII, FIX, and FXI (Table 110- 1) represent a group of ... for plasma coagulation deficiencies are often asymptomati...

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... Recreational drugs (amphetamines) Envenomation Snake Insects Chapter 110. Coagulation Disorders (Part 7) Disseminated Intravascular Coagulation DIC is a clinicopathologic syndrome characterized ... purpura fulminans, with or without thrombosis of large vessels. Table 110- 2 Common Clinical Causes of Disseminated Intravascular Coagulation Sepsis Bacterial Sta...

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... Chapter 110. Coagulation Disorders (Part 8) The central mechanism of DIC is the uncontrolled generation of thrombin by exposure of the blood to pathologic levels of tissue factor (Fig. 110- 3). ... mediating the coagulation defects in DIC and symptoms associated with systemic inflammatory response syndrome. Figure 110- 3 The pathophysiology of disseminated intravas...

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... membranes (Fig. 110- 2). Inherited deficiency of the functional activity of the enzymes involved in vitamin K metabolism, notably the GGCX or VKOR-1 (see above), results in bleeding disorders. The ... proteases (PCCs), which further aggravates the disease. Replacement of Coagulation or Fibrinolysis Inhibitors Drugs to control coagulation such as heparin, antithrombin III (ATIII) co...

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... injection) to improve hemostasis. Table 110- 3 Coagulation Disorders and Hemostasis in Liver Disease Chapter 110. Coagulation Disorders (Part 10) Coagulation Disorders Associated with Liver Failure ... Decreased synthesis of coagulation inhibitors: protein C, protein S, antithrombin Hepatocyte failure Vitamin K deficiency (protein C, protein S) Failure to...

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... whereas acquired inhibitors are specific to a single factor. Further Readings Chapter 110. Coagulation Disorders (Part 11) Treatment with FFP is the most effective way to correct hemostasis ... patients. Critical Care 10:222, 2006 [PMID: 16879728] Mannucci PM, et al: Recessively inherited coagulation disorders. Blood 104:1243, 2004 [PMID: 15138162] Stafford DW: The vi...

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