Chapter 105 Malignancies of Lymphoid Cells (Part 9) Two other features may be used to assess pptx

... Chapter 105. Malignancies of Lymphoid Cells (Part 9) Two other features may be used to assess prognosis in B cell CLL, but neither has yet been incorporated into a staging ... g/dL)] and number of extranodal sites with number of nodal sites (more than four). Low risk (zero or one factor) was assigned to 36% of patients, intermediate risk (two fac...

Ngày tải lên: 07/07/2014, 04:20

... lymphoma Chapter 105. Malignancies of Lymphoid Cells (Part 1) Harrison's Internal Medicine > Chapter 105. Malignancies of Lymphoid Cells Malignancies of Lymphoid Cells: Introduction ... cytochemical stains became available, it was possible to divide these objectively into myeloid malignancies and acute leukemias of lymphoid cells. Ac...

Ngày tải lên: 07/07/2014, 04:20

... lymphoid tissue; NK, natural killer; WHO, World Health Organization. Malignancies in bold occur in at least 1% of patients. Source: Adapted from Harris et al. Chapter 105. Malignancies of ... of Lymphoid Cells (Part 2) Non-Hodgkin's lymphomas were separated from Hodgkin's disease by recognition of the Sternberg-Reed cells early in the twentieth cent...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 3) General Aspects of Lymphoid Malignancies Etiology and Epidemiology The relative frequency of the various lymphoid malignancies ... distribution of age at diagnosis has been observed, with one peak incidence occurring in patients in their twenties and the other in those in their eighties. Some of the l...

Ngày tải lên: 07/07/2014, 04:20

... symptoms of fever, malaise, and weight loss. In addition to infectious agents, a number of other diseases or exposures may predispose to developing lymphoma (Table 105- 5). A number of environmental ... Chapter 105. Malignancies of Lymphoid Cells (Part 4) The incidence of non-Hodgkin's lymphomas and the patterns of expression of the various sub...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 5) Table 105- 5 Diseases or Exposures Associated with Increased Risk of Development of Malignant Lymphoma Inherited ... committed to the lymphoid lineage and then gives rise to B and T cells. About 75% of all lymphoid leukemias and 90% of all lymphomas are of B cell origin. A cell becomes committed t...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 6) Figure 105- 3 In the case of diffuse large B cell lymphoma, the translocation t(14;18) occurs in ~30% of patients and leads to overexpression ... (see below), had to develop early in ontogeny as an error in the process of immunoglobulin gene rearrangement. Why the subsequent steps that led to transformation...

Ngày tải lên: 07/07/2014, 04:20

... challenge remains to provide information from such techniques in a clinically useful time frame. Chapter 105. Malignancies of Lymphoid Cells (Part 7) Table 105- 6 presents the best documented ... ALL, hyperdiploidy has been shown to have a favorable prognosis. Gene profiling using array technology allows the simultaneous assessment of the expression of thousand...

Ngày tải lên: 07/07/2014, 04:20

... either or both of these abnormalities are due to progressive marrow infiltration and loss of productive marrow. However, either or both may be due to autoimmune phenomena or to hypersplenism ... autoimmune hemolytic anemia, autoimmune thrombocytopenia, and hypogammaglobulinemia. Patients with hypogammaglobulinemia benefit from regular (monthly) γ globulin administration. B...

Ngày tải lên: 07/07/2014, 04:20

... Relationship of International Prognostic Index (IPI) to survival. Kaplan- Meier survival curves for 1300 patients with various kinds of lymphoma stratified according to the IPI. Chapter 105. Malignancies ... the IPI. Chapter 105. Malignancies of Lymphoid Cells (Part 10) Table 105- 9 International Prognostic Index for NHL Five clinical risk f...

Ngày tải lên: 07/07/2014, 04:20