Chapter 105 Malignancies of Lymphoid Cells (Part 9) Two other features may be used to assess pptx
Chapter 105. Malignancies of Lymphoid Cells (Part 9) Two other features may be used to assess pptx
... Chapter 105. Malignancies of Lymphoid Cells (Part 9) Two other features may be used to assess prognosis in B cell CLL, but neither has yet been incorporated into a staging ... g/dL)] and number of extranodal sites with number of nodal sites (more than four). Low risk (zero or one factor) was assigned to 36% of patients, intermediate risk (two factors) to 37%, and poor ... classification. At least two subsets of CLL have been identified based on the cytoplasmic expression of ZAP-70; expression of this protein, which is usually expressed in T cells, identifies a subgroup...
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Chapter 105. Malignancies of Lymphoid Cells (Part 1) docx
... lymphoma Chapter 105. Malignancies of Lymphoid Cells (Part 1) Harrison's Internal Medicine > Chapter 105. Malignancies of Lymphoid Cells Malignancies of Lymphoid Cells: Introduction ... cytochemical stains became available, it was possible to divide these objectively into myeloid malignancies and acute leukemias of lymphoid cells. Acute leukemias of lymphoid cells have been ... Introduction Malignancies of lymphoid cells range from the most indolent to the most aggressive human malignancies. These cancers arise from cells of the immune system at different stages of differentiation,...
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Chapter 105. Malignancies of Lymphoid Cells (Part 2) ppt
... lymphoid tissue; NK, natural killer; WHO, World Health Organization. Malignancies in bold occur in at least 1% of patients. Source: Adapted from Harris et al. Chapter 105. Malignancies of ... of Lymphoid Cells (Part 2) Non-Hodgkin's lymphomas were separated from Hodgkin's disease by recognition of the Sternberg-Reed cells early in the twentieth century. The histologic ... classification of lymphoid malignancies was devised through a process of consensus development among international leaders in hematopathology and clinical oncology. The WHO classification takes into account...
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Chapter 105. Malignancies of Lymphoid Cells (Part 3) pptx
... Chapter 105. Malignancies of Lymphoid Cells (Part 3) General Aspects of Lymphoid Malignancies Etiology and Epidemiology The relative frequency of the various lymphoid malignancies ... distribution of age at diagnosis has been observed, with one peak incidence occurring in patients in their twenties and the other in those in their eighties. Some of the late age peak may be attributed ... United States at the rate of 4% per year between 1950 and the late 1990s. The rate of increase in the past few years seems to be decreasing. About 63,190 new cases of non-Hodgkin's lymphoma...
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Chapter 105. Malignancies of Lymphoid Cells (Part 4) pptx
... symptoms of fever, malaise, and weight loss. In addition to infectious agents, a number of other diseases or exposures may predispose to developing lymphoma (Table 105- 5). A number of environmental ... Chapter 105. Malignancies of Lymphoid Cells (Part 4) The incidence of non-Hodgkin's lymphomas and the patterns of expression of the various subtypes differ ... predisposes to the development of aggressive, B cell non-Hodgkin's lymphoma. This may be through overexpression of interleukin 6 by infected macrophages. Infection of the stomach by the...
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Chapter 105. Malignancies of Lymphoid Cells (Part 5) pdf
... Chapter 105. Malignancies of Lymphoid Cells (Part 5) Table 105- 5 Diseases or Exposures Associated with Increased Risk of Development of Malignant Lymphoma Inherited ... committed to the lymphoid lineage and then gives rise to B and T cells. About 75% of all lymphoid leukemias and 90% of all lymphomas are of B cell origin. A cell becomes committed to B cell development ... to lymphoid, myeloid, erythroid, monocyte, and megakaryocyte lineages. Through the ordered and sequential activation of a series of transcription factors, the cell first becomes committed to...
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Chapter 105. Malignancies of Lymphoid Cells (Part 6) pot
... Chapter 105. Malignancies of Lymphoid Cells (Part 6) Figure 105- 3 In the case of diffuse large B cell lymphoma, the translocation t(14;18) occurs in ~30% of patients and leads to overexpression ... (see below), had to develop early in ontogeny as an error in the process of immunoglobulin gene rearrangement. Why the subsequent steps that led to transformation became manifest in a cell of ... receptors must create a site of vulnerability to aberrant recombination. B cells are even more susceptible to acquiring mutations during their maturation in germinal centers; the generation of...
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Chapter 105. Malignancies of Lymphoid Cells (Part 7) docx
... challenge remains to provide information from such techniques in a clinically useful time frame. Chapter 105. Malignancies of Lymphoid Cells (Part 7) Table 105- 6 presents the best documented ... ALL, hyperdiploidy has been shown to have a favorable prognosis. Gene profiling using array technology allows the simultaneous assessment of the expression of thousands of genes. This technology ... either those of follicular center B cells or activated peripheral blood B cells. Patients whose lymphomas have a germinal center B cell pattern of gene expression have a considerably better prognosis...
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Chapter 105. Malignancies of Lymphoid Cells (Part 8) potx
... either or both of these abnormalities are due to progressive marrow infiltration and loss of productive marrow. However, either or both may be due to autoimmune phenomena or to hypersplenism ... autoimmune hemolytic anemia, autoimmune thrombocytopenia, and hypogammaglobulinemia. Patients with hypogammaglobulinemia benefit from regular (monthly) γ globulin administration. Because of ... stage. Table 105- 7 Staging of Typical B Cell Lymphoid Leukemia Stage Clinical Features Median Survival, Years establish rapport with the patient that will make it possible to develop and...
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Chapter 105. Malignancies of Lymphoid Cells (Part 10) potx
... Relationship of International Prognostic Index (IPI) to survival. Kaplan-Meier survival curves for 1300 patients with various kinds of lymphoma stratified according to the IPI. Chapter 105. Malignancies ... the IPI. Chapter 105. Malignancies of Lymphoid Cells (Part 10) Table 105- 9 International Prognostic Index for NHL Five clinical risk factors: Age ≥60 years Serum lactate dehydrogenase ... based upon the type of lymphoma For diffuse large B cell lymphoma: 0, 1 factor = low risk: 35% of cases; 5-year survival, 73% 2 factors = low-intermediate risk: 27% of cases; 5-year...
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