Chapter 102 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 5) pdf

... Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 5) Pathophysiology Bone marrow failure results from severe damage to the hematopoietic cell compartment. In aplastic anemia, replacement ... complexity and specificity of the pathways imply multiple susceptibility loci and would provide an explanation for the rarity of idiosyncratic drug re...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 3) Radiation Marrow aplasia is a major acute sequela ... with aplastic anemia. Benzene is a notorious cause of bone marrow failure. Vast quantities of epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute leukemia, and ....

Ngày tải lên: 07/07/2014, 04:20

... Internal Medicine > Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes: Introduction ... transformation. Table 102- 1 Differential Diagnosis of Pancytopenia Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone...

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... Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 2) Aplastic Anemia Definition Aplastic anemia is pancytopenia with bone marrow hypocellularity. ... hypocellularity. Acquired aplastic anemia is distinguished from iatrogenic marrow aplasia, marrow hypocellularity after intensive cytotoxic chemotherapy for...

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... 316). Pancytopenia with marrow hypoplasia can also occur in systemic lupus erythematosus. Pregnancy Aplastic anemia very rarely may occur and recur during pregnancy and resolve with delivery ... detected in about half of patients with aplastic anemia at the time of presentation [and PNH cells are also seen in MDS (see below)]; frank hemolysis and thrombotic episodes occur i...

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... of aplastic anemia is the restriction of symptoms to the hematologic system, and patients often feel and look remarkably well despite drastically reduced blood counts. Systemic complaints and ... constitutional etiology of marrow failure. Physical Examination Petechiae and ecchymoses are typical, and retinal hemorrhages may be present. Pelvic and rectal examinations c...

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... children and younger adults to exclude Fanconi's anemia. Genetic analysis applicable to the constitutional marrow failure states is available in some laboratories. Chromosome studies of bone marrow ... radiograph (Table 102- 1). Diagnostic problems can occur with atypical presentations and among related hematologic diseases. While pancytopenia is most common, some patie...

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... Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 8) Hematopoietic Stem Cell Transplantation ... Most patients with aplastic anemia lack a suitable marrow donor, and immunosuppression is the treatment of choice. Overall survival is equivalent with transplantation and immunosuppression. ... cures marrow failu...

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... lymphocytes and can respond to immunosuppressive Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 9) Outcomes following both transplant and immunosuppression ... 109), and neutropenia without marrow myeloid cells in agranulocytosis (Chap. 61). In general, and in contrast to aplastic anemia and MDS, the un...

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... individual cases. Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 10) Definition and Differential Diagnosis PRCA is characterized by anemia, reticulocytopenia, ... characterized by anemia, reticulocytopenia, and absent or rare erythroid precursor cells in the bone marrow. The classification of PRCA is sho...

Ngày tải lên: 07/07/2014, 04:20