bone marrow failure syndromes adults

... Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 1) Harrison's Internal Medicine > Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes Aplastic ... leukemia (AML) Some acute lymphoid leukemia Some lymphomas of bone marrow Pancytopenia with Cellular Bone Marrow Primary bone marrow diseases Myelodysplasia Paroxysmal nocturnal Secondary ... leukopenias). Hematopoietic failure syndromes are classified by dominant morphologic features of the bone marrow (Table 102-1). While practical distinction among these syndromes usually is clear,...

Ngày tải lên: 07/07/2014, 04:20

... Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 2) Aplastic Anemia Definition Aplastic anemia is pancytopenia with bone marrow hypocellularity. Acquired aplastic ... anomalies and the development of pancytopenia early in life, can also present as marrow failure in normal-appearing adults. Acquired aplastic anemia is often stereotypical in its manifestations, ... bone marrow hypocellularity. Acquired aplastic anemia is distinguished from iatrogenic marrow aplasia, marrow hypocellularity after intensive cytotoxic chemotherapy for cancer. Aplastic anemia...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 3) Radiation Marrow aplasia is a major acute sequela of radiation. Radiation damages ... a notorious cause of bone marrow failure. Vast quantities of epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute leukemia, and blood and marrow abnormalities. ... environment. The association between marrow failure and other chemicals is much less well substantiated. Drugs (Table 102-3) Many chemotherapeutic drugs have marrow suppression as a major toxicity;...

Ngày tải lên: 07/07/2014, 04:20

... cooperate in a repair complex to maintain telomere length. In Shwachman-Diamond syndrome, marrow failure is seen with pancreatic insufficiency and malabsorption; most patients have compound ... thrombotic episodes occur in patients with large PNH clones (>50%). Functional studies of bone marrow from PNH patients, even those with mainly hemolytic manifestations, show evidence of ... an initial clinical diagnosis of PNH, especially younger individuals, may later develop frank marrow aplasia and pancytopenia; patients with an initial diagnosis of aplastic anemia may suffer...

Ngày tải lên: 07/07/2014, 04:20

... Related Bone Marrow Failure Syndromes (Part 5) Pathophysiology Bone marrow failure results from severe damage to the hematopoietic cell compartment. In aplastic anemia, replacement of the bone ... responsible for benzene-induced tissue injury. Excessive generation of toxic intermediates or failure to detoxify the intermediates may be genetically determined and apparent only on specific ... severe damage to the hematopoietic cell compartment. In aplastic anemia, replacement of the bone marrow by fat is apparent in the morphology of the biopsy specimen (Fig. 102-1) and MRI of the...

Ngày tải lên: 07/07/2014, 04:20

... history of hematologic diseases or blood abnormalities may indicate a constitutional etiology of marrow failure. Physical Examination Petechiae and ecchymoses are typical, and retinal hemorrhages ... expression on CD34 cells, leading to apoptotic cell death; localization of activated T cells to bone marrow and local production of their soluble factors are probably important in stem cell destruction. ... presence of immature myeloid forms suggests leukemia or MDS; nucleated red blood cells suggest marrow fibrosis or tumor invasion; abnormal platelets suggest either peripheral destruction or...

Ngày tải lên: 07/07/2014, 04:20

... anemia. Genetic analysis applicable to the constitutional marrow failure states is available in some laboratories. Chromosome studies of bone marrow cells are often revealing in MDS and should be ... patients with bone marrow hypocellularity have depression of only one or two of three blood lines, sometimes showing later progression to more recognizable aplastic anemia. The bone marrow in constitutional ... etiology of the marrow failure. Ancillary Studies Chromosome breakage studies of peripheral blood using diepoxybutane or mitomycin C should be performed on children and younger adults to exclude...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

... resurrection after bone- marrow- derived Anastasiadis et al. Journal of Translational Medicine 2011, 9:12 http://www.translational-medicine.com/content/9/1/12 Page 4 of 5 Chronic ischemic heart failure epidemic. ... al.: Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion. Journal of Translational ... Cardiol 2002, 39:1189-1198. 8. McMurray JV, Pfeffer MA: Heart failure. Lancet 2005, 365:1877-1889. 9. Gheorghiade M, Bonow RO: Chronic heart failure in the United States: a manifestation of coronary...

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... http://www.medsci.org 75 searchers have transplanted the bone marrow stem cells into the necrotic femoral heads, and results show bone marrow stem cells can remove vascular lesions and promote ... GFP labeled MSCs were noted in the lungs, liver, bone marrow and normal and necrotic femoral heads of rabbits, and the number of MSCs in bone marrow was higher than that in the, femoral head, ... with autologous bone marrow grafting. Indian J Orthop. 2009 Jan;43(1):40-45 35. Sun Y, Feng Y, Zhang C. The effect of bone marrow mononu- clear cells on vascularization and bone regeneration in...

Ngày tải lên: 25/10/2012, 11:18

... All rights reserved Research paper Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice Marco ... hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on ... cancer therapeutic regimen. In the present study, we investigated whether AP could protect the bone marrow and the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled...

Ngày tải lên: 02/11/2012, 10:19