Chapter 074 Biology of Obesity (Part 1) ppsx
Chapter 074. Biology of Obesity (Part 1) ppsx
... role in systemic complications of obesity is an area of active
investigation.
Definition and Measurement
Obesity is a state of excess adipose tissue mass. Although often viewed as
equivalent ... measure of adiposity, the most widely used method to
gauge obesity is the body mass index (BMI), which is equal to weight/height
2
(in
kg/m
2
) (Fig. 74 -1). Other approaches to qu...
Chapter 074. Biology of Obesity (Part 4) ppsx
... common forms of obesity.
Figure 74-4
Chapter 074. Biology of Obesity
(Part 4)
SPECIFIC GENETIC SYNDROMES
For many years obesity in rodents has been known to be caused by a
number of distinct ... several other genes cause severe obesity in humans (Table 74-
1); each of these syndromes is rare. Mutations in the gene encoding
proopiomelanocortin (POMC) cause sever...
Chapter 074. Biology of Obesity (Part 2) pdf
... expenditure includes the following components: (1) resting or basal
metabolic rate; (2) the energy cost of metabolizing and storing food; (3) the
thermic effect of exercise; and (4) adaptive thermogenesis, ... activity of
BAT is increased by a central action of leptin, acting through the sympathetic
nervous system, which heavily innervates this tissue. In rodents, BAT deficiency...
Chapter 074. Biology of Obesity (Part 5) docx
... Chapter 074. Biology of Obesity
(Part 5)
Figure 74-5
A central pathway through which leptin acts to regulate ... for hypothalamic mediators of human obesity or
leanness. The tub gene encodes a hypothalamic peptide of unknown function;
mutation of this gene causes late-onset obesity. The fat gene encodes ...
associated with obesity (Table 74-2). Although specif...
Chapter 074. Biology of Obesity (Part 6) ppt
... that is in the
Chapter 074. Biology of Obesity
(Part 6)
OTHER SPECIFIC SYNDROMES ASSOCIATED WITH OBESITY
Cushing's Syndrome
Although obese patients commonly have central obesity, hypertension, ...
PATHOGENESIS OF COMMON OBESITY
Obesity can result from increased energy intake, decreased energy
expenditure, or a combination of the two. Thus, identifying the e...
Chapter 074. Biology of Obesity (Part 7) ppt
... sensitivity and often improve glucose control in diabetes.
Chapter 074. Biology of Obesity
(Part 7)
WHAT IS THE STATE OF ENERGY EXPENDITURE IN
OBESITY?
The average total daily energy expenditure ...
Pathologic Consequences of Obesity
(See also Chap. 75) Obesity has major adverse effects on health. Obesity is
associated with an increase in mortality, with a 50–10...
Chapter 075. Evaluation and Management of Obesity (Part 1) ppt
... 76
Chapter 075. Evaluation and
Management of Obesity
(Part 1)
Harrison's Internal Medicine > Chapter 75. Evaluation and Management
of Obesity
Evaluation and Management of Obesity: ... Blood
Institute (NHLBI) and a number of medical societies. The five main steps in the
evaluation of obesity are described below and include (1) focused obesity- relate...
Chapter 075. Evaluation and Management of Obesity (Part 7) ppsx
... Lifestyle modification for the management of obesity.
Gastroenterology 132(6):2226, 2007 [PMID: 17498514]
Chapter 075. Evaluation and
Management of Obesity
(Part 7)
The three restrictive-malabsorptive ... Association for
the Study of Obesity: Practical guide: Identification, evaluation, and treatment of
overweight and obesity in adults. Bethesda, MD, National...
Chapter 107. Transfusion Biology and Therapy (Part 1) ppsx
... antigens may block this binding.
Chapter 107. Transfusion
Biology and Therapy
(Part 1)
Harrison's Internal Medicine > Chapter 107. Transfusion Biology and
Therapy
Blood Group ... formed by the
addition of fucose to the glycolipid or glycoprotein backbone. The subsequent
addition of N-acetylgalactosamine creates the A antigen, while the addition of
galactose...
