Chapter 066 Stem Cell Biology (Part 2) pdf
Chapter 066. Stem Cell Biology (Part 2) pdf
... another cell type) and are not, therefore, considered unipotent cells. Chapter 066. Stem Cell Biology (Part 2) Self-Renewal and Proliferation of Stem Cells Symmetric and Asymmetric Cell Division ... cultured stem cells. For abbreviations of stem cells, see Table 66-1. Note that stem cells are often abbreviated with or without "cells," e.g., ES cells or ESCs for embryonic stem cells. ... germ cells. Multipotent cells (e.g., HS cells) can form multiple cell lineages but cannot form all of the body's cell lineages. Oligopotent cells (e.g., NS cells) can form more than one cell...
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Chapter 066. Stem Cell Biology (Part 3) pdf
... oocyte to produce live offspring. Molecular Characterization of Stem Cells Genomics and Proteomics Chapter 066. Stem Cell Biology (Part 3) Nuclear Reprogramming Development naturally progresses ... Differentiation of Stem Cells Pluripotent stem cells (e.g., ES cells) can differentiate into multiple cell types, but in culture they normally differentiate into heterogeneous cell populations ... therapeutic uses, it is desirable to direct stem cells into specific cell types (e.g., insulin-secreting beta cells). This is an active area of stem cell research, and protocols are being developed...
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Chapter 066. Stem Cell Biology (Part 1) potx
... Biology (Part 1) Harrison's Internal Medicine > Chapter 66. Stem Cell Biology Stem Cell Biology: Introduction Stem cell biology is a relatively new field that explores the characteristics ... Isolation, and Derivation of Stem Cells Resident Stem Cells The definition of stem cells remains elusive. Stem cells were originally postulated as unspecified or undifferentiated cells that provide ... various cell lineages of mesodermal, ectodermal, and endodermal origin in vitro (m). Spermatogonial SS cells can be derived by culturing newborn Chapter 066. Stem Cell Biology (Part 1)...
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Chapter 035. Hypoxia and Cyanosis (Part 2) pdf
... simultaneously: (1) increasing the cardiac output and ventilation and, thus, O2 delivery to the tissues; (2) preferentially directing the blood to the exercising muscles by changing vascular resistances ... IMPROPER OXYGEN UTILIZATION Cyanide (Chap. e35) and several other similarly acting poisons cause cellular hypoxia. The tissues are unable to utilize O2, and as a consequence, the venous blood ... inflow. Edema, which increases the distance through which O2 must diffuse before it reaches cells, can also cause localized hypoxia. In an attempt to maintain adequate perfusion to more vital...
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Chapter 099. Disorders of Hemoglobin (Part 2) pdf
... ubiquitous (e.g., Sp1 and YY1), while others are more or less limited to erythroid cells or hematopoietic cells (e.g., GATA-1, NFE-2, and EKLF). The LCR controlling the α-globin gene cluster ... charged amino acids, and interaction with protons or 2,3-BPG. Developmental Biology of Human Hemoglobins Red cells first appearing at about 6 weeks after conception contain the embryonic ... normal gestation. Small amounts of HbF are produced during postnatal life. A few red cell clones called F cells are progeny of a small pool of immature committed erythroid precursors (BFU-e)...
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Chapter 106. Plasma Cell Disorders (Part 2) potx
... Golgi apparatus. Binucleate and multinucleate malignant plasma cells can be seen. Chapter 106. Plasma Cell Disorders (Part 2) Figure 106-1 Representative patterns of serum electrophoresis. ... petroleum products. The neoplastic event in myeloma may involve cells earlier in B cell differentiation than the plasma cell. Circulating B cells bearing surface immunoglobulin that share the clear ... and 11q abnormalities predominate. The most common translocations are t(11;14)(q13;q 32) and t(4;14)(p16;q 32), and evidence is strong that errors in switch recombination—the genetic mechanism...
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Chapter 108. Hematopoietic Cell Transplantation (Part 2) ppt
... of bone marrow have also been shown to diminish tumor cell numbers in stem cell products. Another technique is positive selection of stem cells using antibodies to CD34, generally required for ... studying the use of peripheral blood stem cells for allogeneic transplantation was because peripheral blood stem cell products contain as much as one log more T cells than are contained in the typical ... adherence or flow techniques to select normal stem cells while leaving tumor cells behind. All these approaches can reduce the number of tumor cells from 1000- to 10,000-fold and are clinically...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) pps
... Medicine (Part 2) Strategies for Stem Cell Replacement Stem cell transplantation is not a new concept and it is already part of established medical practice. Hematopoietic stem cells (HSCs) ... the damaged tissue; (2) in vitro differentiation of stem cells followed by transplantation into a damaged organ—e.g., pancreatic islet cells could be generated from stem cells prior to transplantation ... strategies for cell replacement, the ex vivo or in situ generation of tissues provides an alternative means of tissue engineering (Chap. 69). Stem cells are also excellent vehicles for cellular...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) ppt
... of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells for treatment of the brain), and somatic stem cells ... obtaining more pluripotent stem cell populations, such as bone marrow mesenchymal stem cells (MSCs) or adipose stem cells, for use in regenerative strategies. Sources of Stem Cells for Tissue Repair ... regenerated tissue. Each organ system will also pose tissue-specific problems for stem cell therapies. Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) Harrison's...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 3) pot
... available cells also limits this strategy. Potential sources of stem cells include endogenous liver stem cells (such as oval cells), ES cells, bone marrow cells, and umbilical cord blood cells. ... diabetes. Nervous System Neural cells have been differentiated from a variety of stem cell populations. Human ES cells can be induced to generate neural stem cells, and these cells can give rise ... engineer cells to produce factors that will enhance cell survival. Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 3) Diabetes Mellitus The success of islet cell...
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