stem cell biology books pdf

... cultured stem cells. For abbreviations of stem cells, see Table 66-1. Note that stem cells are often abbreviated with or without "cells," e.g., ES cells or ESCs for embryonic stem cells. ... germ cells. Multipotent cells (e.g., HS cells) can form multiple cell lineages but cannot form all of the body's cell lineages. Oligopotent cells (e.g., NS cells) can form more than one cell ... another cell type) and are not, therefore, considered unipotent cells. Chapter 066. Stem Cell Biology (Part 2) Self-Renewal and Proliferation of Stem Cells Symmetric and Asymmetric Cell...

Ngày tải lên: 07/07/2014, 01:20

... Differentiation of Stem Cells Pluripotent stem cells (e.g., ES cells) can differentiate into multiple cell types, but in culture they normally differentiate into heterogeneous cell populations ... therapeutic uses, it is desirable to direct stem cells into specific cell types (e.g., insulin-secreting beta cells). This is an active area of stem cell research, and protocols are being developed ... Stemness This term has been used to designate the essential molecular characteristics of stem cells. It is also used to indicate common genetic programs shared among ES cells and tissue stem...

Ngày tải lên: 07/07/2014, 01:20

... the syncytial hyp7 hypodermal cell which surrounds the VPC equivalence Figure 2 (See facing page for legend.) Cell Cycle Control 83 division plane, and therefore cell cell or cell extracellular matrix con- tacts, ... Issues 1 Introduction: Stem Cell Biology, 1 Daniel R. Marshak, David Gottlieb, and Richard L. Gardner 2 Differentiated Parental DNA Chain Causes Stem Cell Pattern of Cell- type Switching in ... Notch/LIN-12 Communication System, 37 Domingos Henrique 4 Cell Cycle Control, Checkpoints, and Stem Cell Biology, 61 Gennaro D’Urso and Sumana Datta 5 Senescence of Dividing Somatic Cells, 95 Robin Holliday 6...

Ngày tải lên: 08/04/2014, 12:53

... (Part 1) Harrison's Internal Medicine > Chapter 66. Stem Cell Biology Stem Cell Biology: Introduction Stem cell biology is a relatively new field that explores the characteristics ... Isolation, and Derivation of Stem Cells Resident Stem Cells The definition of stem cells remains elusive. Stem cells were originally postulated as unspecified or undifferentiated cells that provide ... number and types of cultured stem cells have increased progressively (Table 66-1). The cultured stem cells derived from resident stem cells are often called adult stem cells to indicate their adult...

Ngày tải lên: 07/07/2014, 01:20

... of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells for treatment of the brain), and somatic stem cells ... obtaining more pluripotent stem cell populations, such as bone marrow mesenchymal stem cells (MSCs) or adipose stem cells, for use in regenerative strategies. Sources of Stem Cells for Tissue Repair ... stem cells. Umbilical cord blood stem/ progenitor cells are associated with less graft- versus-host disease compared to marrow stem cells. They have less HLA restriction than adult marrow stem...

Ngày tải lên: 07/07/2014, 01:20

... (Part 2) Strategies for Stem Cell Replacement Stem cell transplantation is not a new concept and it is already part of established medical practice. Hematopoietic stem cells (HSCs) (Chap. 68) ... stem cells to facilitate repair—e.g., administration of appropriate growth factors to amplify numbers of endogenous stem/ progenitor cells or direct them to differentiate into the desired cell ... strategies for cell replacement, the ex vivo or in situ generation of tissues provides an alternative means of tissue engineering (Chap. 69). Stem cells are also excellent vehicles for cellular...

Ngày tải lên: 07/07/2014, 01:20

... available cells also limits this strategy. Potential sources of stem cells include endogenous liver stem cells (such as oval cells), ES cells, bone marrow cells, and umbilical cord blood cells. ... diabetes. Nervous System Neural cells have been differentiated from a variety of stem cell populations. Human ES cells can be induced to generate neural stem cells, and these cells can give rise ... of different cell types are candidates for use in stem cell replacement, including ES cells, hepatic progenitor cells, pancreatic ductal progenitor cells, and bone marrow stem cells. Successful...

Ngày tải lên: 07/07/2014, 01:20

... Essentials of Stem Cell Biology. San Diego, Elsevier Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 4) Other Organ Systems and the Future The use of stem cells in ... Applications of Stem Cell Research et al: Stem Cells and the Future of Regenerative Medicine. Washington, D.C., National Academies Press, 2002 Holland S et al: The Human Embryonic Stem Cell Debate: ... 17671448] National Institutes of Health: Stem cell information page. URL: http://stemcells.nih.gov/index.asp. Puceat M, Ballis A: Embryonic stem cells: From bench to bedside. Clin Pharmacol...

Ngày tải lên: 07/07/2014, 01:20

... effector T cells upon recognition of the beta -cell- specific peptide bound to MHC class I molecules in the presence of beta -cell- specific CD4 + T helper cells. The cytotoxic CD8 + T cells then ... affect beta -cell damage by releasing perforin and granzyme, and by Fas-mediated apoptosis. In this way, macrophages, CD4+ T cells, and CD8+ T cells synergistically destroy beta-cells, resulting ... that lead to beta -cell- specific T cell activation (The term cross-presentation denotes the ability of certain antigen-presenting cells to take up, process and present extracellular antigens...

Ngày tải lên: 16/03/2014, 21:20

... dif- ferent cell lines at the six chosen temperatures, from 0 to 30°C. The substrates studied were CHO cells stably transfected with human A 3 adenosine receptors, Jurkat T cells, A375 and HL60 cell ... Auchampach 11 A 3 Adenosine Receptor in the Pulmonary System 209 Yifat Klein and Idit Matot 12 A 3 Adenosine Receptor Regulation of Cells of the Immune System and Modulation of Inflammation 235 Stefania ... evidence that in the human mast cell line, HMC-1 (which although derived from a patient with mast cell leukaemia shows some biochemical characteristics similar to the mast cells of the lung (Feoktistov...

Ngày tải lên: 22/03/2014, 23:20

... accom- panied by cell sorting to mini mise the number of pluri/ multipotent stem cells in the cell preparation [86], or to separate tumourigenic stem cells from non-tumouri- genic stem cells (by e.g. cell ... cultured cells, includ- ing stem cells. These risk factors are not unique to stem cells and apply to all cell based medicinal products. Donor history is of particular importance for stem cell lines ... Approach for the Generation of Induced Pluripotent Stem Cells. Cell Stem Cell 2008, 2:525-528. 81. Uccelli A, Moretta L, Pistoia V: Mesenchymal stem cells in health and disease. Nature Reviews Immunology...

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