Chapter 003 Decision-Making in Clinical Medicine (Part 4) doc

... influence this role include the physician's knowledge, training, and experience. It is obvious that physicians cannot practice evidence-based medicine (EBM; described later in the chapter) if ... therapy in their heart failure patients because they are more familiar with what the targets are (as defined by large clinical trials), have more familiarity with the specific drugs...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 003. Decision-Making in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical Medicine Decision-Making in Clinical Medicine: ... Uncertainty is compounded by the information overload that characterizes modern medicine. Today's experienced clinician needs close to 2 million pieces of inform...

Ngày tải lên: 06/07/2014, 08:20

... predictive value is best avoided in favor of the more informative posttest probability. Chapter 003. Decision-Making in Clinical Medicine (Part 6) Calculating sensitivity and specificity ... response in a treadmill exercise test) to the exclusion of other potentially relevant data. In addition, ROC area comparisons do not simulate the way test information is actuall...

Ngày tải lên: 06/07/2014, 08:20

... whereas test specificity will be higher in outpatients. times more likely in a patient with the disease than in a patient without it. Most tests in medicine have likelihood ratios for a positive ... finding of a reversible exercise-induced perfusion defect has both a sensitivity and specificity of 90%, yielding a likelihood ratio for a positive test of 9.0 [0.90/(1 – 0.90)]. I...

Ngày tải lên: 06/07/2014, 08:20

... considered, their relevant Chapter 003. Decision-Making in Clinical Medicine (Part 8) Statistical Prediction Models Bayes' theorem, as presented above, deals with a clinical prediction problem ... of HIV infection and the prevalence and incidence of HIV infection in the population targeted. This model, which required over 75 separate data points, provides novel...

Ngày tải lên: 06/07/2014, 08:20

... are on an ACE inhibitor. Routine measurement and reporting of such quality indicators can Reilly BM et al: Translating clinical research into clinical practice: Impact of using prediction ... little or no supporting evidence and, thus, reflect the expert consensus of the guideline panel. In part to protect against errors by individual panels, the final step in guideline construct...

Ngày tải lên: 06/07/2014, 08:20

... other institutions Cochra Collection http://www.cochrane.org Subscrip Chapter 003. Decision-Making in Clinical Medicine (Part 9) Evidence-Based Medicine The "art of medicine& quot; ... traditionally defined as a practice combining medical knowledge (including scientific evidence), intuition, and judgment in the care of patients (Chap. 1). Evidence-based m...

Ngày tải lên: 06/07/2014, 08:20

... disorder. In addition to molecular testing for established disease, genetic testing for susceptibility to chronic disease is being increasingly integrated into the practice of medicine. In most ... majority of adult-onset, multifactorial genetic Chapter 064. The Practice of Genetics in Clinical Medicine (Part 4) Figure 64-2 disorders, testing is purely predictive. Te...

Ngày tải lên: 07/07/2014, 01:20

... expression of angiogenesis inhibitors such as angiostatin and endostatin; use of siRNA to reduce levels of Chapter 065. Gene Therapy in Clinical Medicine (Part 4) Another local approach ... encoding a T cell receptor–like molecule, with a tumor antigen–binding domain fused to an intracellular signaling domain to allow T cell activation, thereby converting normal lymphocyt...

Ngày tải lên: 07/07/2014, 01:20

... Diego, Elsevier Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 4) Other Organ Systems and the Future The use of stem cells in regenerative medicine has been studied ... Stem cells: A revolution in therapeutics- recent advances in stem cell biology and thei r therapeutic applications in regenerative medicine and cancer therapies. Clin...

Ngày tải lên: 07/07/2014, 01:20