best evidence in clinical medicine systematic reviews and meta analysis

... abstraction After pretesting and refining the forms on two trials of surfactant therapy in adults and clarifying definitions based on feedback from the reviewers, two reviewers then independently abstracted ... (respiratory therapist not involved in patient care) 100% More immunosuppressed in control group (30 versus 22) Yes No aPatients randomized but not included in the analysis bPotentially clinically significant ... population) and abstraction of clinically important outcomes in duplicate, independently blinded to information that may bias evaluation The strength of the inference we can make from our subgroup analysis...

Ngày tải lên: 13/08/2014, 03:21

... prevented analysis of pooled data This finding is in contrast with that reported for preterm neonates The systematic reviews and metaanalyses overall provide no evidence that HFO as the initial ... derived from randomised and non-randomised studies Health Technol Assess 2000, 4:1-154 Shapiro S: Meta- analysis/ Shmeta -analysis Am J Epidemiol 1994, 140:771-778 Greenland S: Can meta- analysis be ... Watson RS, Martin LD: Inspiratory work of breathing is not decreased by flow-triggered sensing during spontaneous breathing in children receiving mechanical ventilation: a preliminary report Pediatr...

Ngày tải lên: 14/08/2014, 07:21

... ordinal and interval scales is inadequate in relation to meta- analysis Ann Rheum Dis 2001, 60:349-352 Barden J: Meta- analysis to investigate methodological issues in clinical trials using pain ... anti-inflammatory drug Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded ... extraction, analysis, and preparing the manuscript; SD with data extraction, analysis, and writing; GTM with planning, data extraction, analysis, and writing the manuscript; HJM with planning, analysis, ...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20

... standard guidelines and methods for systematic reviews and meta- analyses of diagnostic tests [18–21] Search Methods We previously published systematic and narrative reviews on the accuracy and ... systemic review and meta- analysis to determine IGRA test performance in persons with suspected or confirmed active pulmonary tuberculosis living in low- and middle-income settings modeling, which ... was performed with blinding to IGRA results Industry involvement was unknown in studies (19%) and acknowledged in (30%), including donation of IGRA kits (6 studies) and work and/ or financial relationships...

Ngày tải lên: 22/03/2014, 18:20

... regimens including pyrazinamide, 31% received drug regimens including a fluoroquinolone, and 17% received drug regimens including streptomycin Induction drug regimens consisted of drugs in 5% of ... fluoroquinolone in 52%, pyrazinamide in 18%, and streptomycin in 14% Most maintenance regimens consisted of 2-drug (46%) or 3-drug (29%) regimens No patients received single-drug MTB therapy during induction ... pulmonary MTB infection was defined as including lung or mediastinal lymph node involvement We defined multiorgan (ie, miliary) MTB infection as involvement of or more organs (lymph nodes draining infected...

Ngày tải lên: 29/03/2014, 03:20

... the original idea for the paper and vouches for the integrity of the analysis DW, UM and MVG extracted and analysed the data All authors collaborated in interpreting the data and writing the ... decreasing asbestos exposure in the Brazil chrysotile mines and mills Occup Environ Med 2005, 62:381-389 Kilburn KH, Warshaw RH, Einstein K, Bernstein J: Airway disease in nonsmoking asbestos ... radiological findings for other lung function parameters [33,32] There is evidence from clinical studies that discrepancies between lung function and radiological findings can be due to asbestos-induced...

Ngày tải lên: 20/06/2014, 00:20

... Results of an influence analysis in which the metaanalysis is re-estimated omitting each study in turn Rerunning the analysis without the study by Mathias and Kent [32] increased the standardised ... overall meta- analysis summary The influence of individual studies on the estimated overall effect size (removing each study and recalculating overall effect) was minor Rerunning the meta- analysis ... synthesis Meta- analyses were carried out using Stata V 9.1 (Stata, College Station, TX, USA) using the user-contributed commands for meta- analyses: ‘metan’ [19], ‘metainf’ [20], ‘metabias’ [21] and ‘metatrim’...

Ngày tải lên: 09/08/2014, 01:21

... homogeneity tests in meta- analyses in pain using simulations of individual patient data Pain 2000, 85:415-424 33 L'Abbe KA, Detsky AS, O'Rourke K: Meta- analysis in clinical research Ann Intern Med 1987, ... treatment as defined by the original authors (mainly urine protein excretion, serum creatinine or creatinine clearance, or a combination of these) and subsequent relapse Adverse events sought included ... tailing doses of MMF and appeared to involve both induction and maintenance Only one trial [39] was clearly a maintenance regimen of MMF in a comparison with both cyclophosphamide and azathioprine,...

Ngày tải lên: 09/08/2014, 08:23

... overall meta- analysis results in the randomized clinical trials Comparison of (a) the forced vital capacity (FVC) and (b) the diffusing overall meta- analysis results in the randomized clinical ... counted in our nine studies included two cases of hemorrhagic cystitis [17] and several cases of hematuria – one case in Valentini and colleagues [18], two cases in Hoyles and colleagues [10] and nine ... analysis, and in manuscript preparation CPW and ELM participated in the study design, data acquisition and analysis, and in manuscript preparation PJE participated in data acquisition and in manuscript...

Ngày tải lên: 09/08/2014, 13:22

... combination of offspring, siblings and/ or parents In the first of these studies [14], the ages of all three groups were similar, suggesting that the relatives group were principally siblings and ... the indexing of the omitted paper was scrutinized, and the search strategy was modified and re-run This process continued until no new papers were identified The original search performed in September ... (although adequate blinding is difficult to attain and this bias cannot be fully eliminated); and degree of age matching between comparison groups (see table 2) Data were extracted independently by...

Ngày tải lên: 11/08/2014, 15:22

... ethically inappropriate considering the documented symptomatic and functional benefits of many treatments in PAH This illustrates the role of a meta- analysis in determining the improvement in mortality ... This analysis was based on 1404 patients from eleven studies that evaluated prostacyclin or prostacyclin analogues, including intravenous epoprostenol and treprostinil, subcutaneous treprostinil, ... compared trepostinil to placebo [18] The study of intravenous treprostinil and one study of inhaled treprostinil were published in abstract form only, but provided sufficient information for analysis...

Ngày tải lên: 12/08/2014, 11:20

... training protocol was at least (on average) 40% of maxHR or if the training protocol included exercise involving at least one-sixth of the skeletal muscles (for example, walking, running, biking, ... Aerobic exercise combined with education or psychotherapy or pharmacotherapy 35 of studies included in meta- analysis Figure Preferred Reporting Items for Systematic Reviews and Meta- Analyses flow ... post treatment, and on pain, fatigue and sleep at follow-up Continuing exercise is necessary to maintain positive effects on pain Page of 14 The following statements are valid for pain reduction...

Ngày tải lên: 12/08/2014, 12:20

... assessing the quality of non randomised studies in meta- analysis [http://www.ohri.ca/programs/ clinical_ epidemiology/oxford.htm] DerSimonian R, Laird N: Meta- analysis in clinical trials Control Clin ... review 29 studies included in updated meta- analysis 31 studies included from Strachan and Cook Review 60 studies included in updated meta- analysis Figure Flow diagram of included and excluded studies ... studies has increased substantially since the original systematic review was published however, and the updated systematic review and meta- analysis described in the present study combines data...

Ngày tải lên: 12/08/2014, 13:22

... patients receiving PDT and ST varies greatly in different practice settings, with ST being performed exclusively in some ICUs, PDT being performed almost exclusively in others and others using a mixture ... MEDLINE (inception to 2005), EMBASE (inception to 2005), CINAHL (inception to 2005) and the Cochrane Controlled Clinical Trials Register databases (inception to 2005) were searched via OVID MEDLINE ... critically ill patients remains unanswered To address these shortcomings and provide a comprehensive and contemporary overview, we performed a systematic review and meta- analysis to investigate whether,...

Ngày tải lên: 12/08/2014, 23:23

... this evidence of clinical efficacy into context, it is also important to take into account the costs and difficulties involved in implementing non-invasive ventilation in clinical practice and ... preferred intervention in ACPE patients Finally, we think it is important for researchers in this field to create consensus guidelines over methods for reporting and defining population, interventions ... for measuring efficacy and side effects because clinicians find it a more intuitive and interpretable metric as it measures the absolute difference between outcome risks in intervention and control...

Ngày tải lên: 12/08/2014, 23:23

... technique of drainage, including the use of imaging guidance, the level of training of the operator, and the type of drainage procedure performed; and outcomes Only outcomes reported in mechanically ... participated in data analysis and manuscript preparation NA participated in data analysis and manuscript preparation NF participated in study design and manuscript preparation Competing interests ... differences for analyzing continuous outcome variables in meta- analysis: a simulation study BMC Med Res Methodol 2008, 8:32 29 Higgins JP, Thompson SG: Quantifying heterogeneity in a meta- analysis Stat...

Ngày tải lên: 14/08/2014, 07:21

... Medical (mixed, n = 7) Table Baseline characteristics and outcomes in intervention and control groups in 14 studies included in metaanalysis Author: Year Creatinine* Urea* APACHE II score Early ... RIFLE Criteria Risk: Increase in serum Creatinine by 1.5 times or urine output

Ngày tải lên: 14/08/2014, 07:21

... reduce falls in older people with dementia living in the community: A systematic review and meta- analysis Clin Interv Aging 2015;9:421–34 20 Guo J, Tsai Y, Liao J, Tu H, Huang C Interventions ... falls and fractures in hospitals and care homes and effect of cognitive impairment: Systematic review and meta- analyses BMJ 2007;334:82–7 26 Winter H, Watt K, Peel NM Falls prevention interventions ... multifaceted intervention on falls in nursing home residents J Am Geriatr Soc 2003;51:306–13 38 Jensen J, Lundin-Olsson L, Nyberg L, Gustafson Y Fall and injury prevention in older people living in residential...

Ngày tải lên: 25/08/2016, 21:43

... falls in older people Clinical practice guideline Oliver, D., Healey, F., & Haines, T P (2010) Preventing falls and fall-related injuries in hospitals Clinics in Geriatric Medicine, 26, 645–692 Perell, ... Repeated falls and their consequences often have led to the initial institutionalization of the NHR and falls continue to affect the residents’ remaining independence, once they are living in a facility ... meta- analysis are in common with our previous one in community-dwelling older people (Deandrea et al., 2010) They were discussed in detail in that article, and are briefly summarized here We included...

Ngày tải lên: 25/08/2016, 23:00