Chapter 003 Decision-Making in Clinical Medicine (Part 1) doc
Chapter 003. Decision-Making in Clinical Medicine (Part 1) doc
... Chapter 003. Decision-Making in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical Medicine Decision-Making in Clinical Medicine: ... Uncertainty is compounded by the information overload that characterizes modern medicine. Today's experienced clinician needs close to 2 million pieces of information to practice medicine. Doctors ... Despite the great technological advances of medicine over the last century, uncertainty still plays a pivotal role in all aspects of medical decision-making. We may know that a patient does not...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 1) doc
... No Chapter 065. Gene Therapy in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 65. Gene Therapy in Clinical Medicine Gene Therapy in Clinical Medicine: Introduction ... transfer in dividing cells gene transfer in transduced tissues effective in transducing various tissues few inflammatory responses, nonpathogenic gene expression in both dividing and ... steps in which the donated DNA enters the target cell and begins expression is referred to as transduction. Gene delivery can take place in vivo, in which the vector is directly injected into...
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Chapter 003. Decision-Making in Clinical Medicine (Part 4) doc
... influence this role include the physician's knowledge, training, and experience. It is obvious that physicians cannot practice evidence-based medicine (EBM; described later in the chapter) if ... therapy in their heart failure patients because they are more familiar with what the targets are (as defined by large clinical trials), have more familiarity with the specific drugs (including ... are less likely to overreact to foreseeable problems in therapy such as a rise in creatinine levels or symptomatic hypotension. Other intriguing research has shown a wide distribution of acceptance...
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Chapter 003. Decision-Making in Clinical Medicine (Part 6) doc
... predictive value is best avoided in favor of the more informative posttest probability. Chapter 003. Decision-Making in Clinical Medicine (Part 6) Calculating sensitivity and specificity ... response in a treadmill exercise test) to the exclusion of other potentially relevant data. In addition, ROC area comparisons do not simulate the way test information is actually used in clinical ... measure of the information content of a test. Values range from 0.5 (no diagnostic information at all, test is equivalent to flipping a coin) to 1.0 (perfect test). In the testing literature,...
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Chapter 003. Decision-Making in Clinical Medicine (Part 7) docx
... whereas test specificity will be higher in outpatients. times more likely in a patient with the disease than in a patient without it. Most tests in medicine have likelihood ratios for a positive ... finding of a reversible exercise-induced perfusion defect has both a sensitivity and specificity of 90%, yielding a likelihood ratio for a positive test of 9.0 [0.90/(1 – 0.90)]. If we again ... change management. In fact, the test has moved us from being fairly certain that the patient did not have CAD to being completely undecided (a 50:50 chance of disease). In a patient with a...
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Chapter 003. Decision-Making in Clinical Medicine (Part 8) docx
... considered, their relevant Chapter 003. Decision-Making in Clinical Medicine (Part 8) Statistical Prediction Models Bayes' theorem, as presented above, deals with a clinical prediction problem ... of HIV infection and the prevalence and incidence of HIV infection in the population targeted. This model, which required over 75 separate data points, provides novel insights into a clinical ... enhance understanding of the most important questions that deserve particular attention in clinical decision-making instead of the small handful of data that clinicians can manage in their heads...
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Chapter 003. Decision-Making in Clinical Medicine (Part 11) docx
... are on an ACE inhibitor. Routine measurement and reporting of such quality indicators can Reilly BM et al: Translating clinical research into clinical practice: Impact of using prediction ... little or no supporting evidence and, thus, reflect the expert consensus of the guideline panel. In part to protect against errors by individual panels, the final step in guideline construction ... Refining clinical diagnosis with likelihood ratios. Lancet 365:1500, 2005 [PMID: 15850636] Haynes RB et al: Clinical Epidemiology: How to Do Clinical Practice Research. Philadelphia, Lippincott...
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Chapter 003. Decision-Making in Clinical Medicine (Part 9) doc
... other institutions Cochra Collection http://www.cochrane.org Subscrip Chapter 003. Decision-Making in Clinical Medicine (Part 9) Evidence-Based Medicine The "art of medicine& quot; ... traditionally defined as a practice combining medical knowledge (including scientific evidence), intuition, and judgment in the care of patients (Chap. 1). Evidence-based medicine (EBM) updates ... problem in question (Table 3-3). Table 3-3 Selected Tools for Finding the Evidence in Evidence-Based Medicine Name Description Web Address Availability Evidence-Based Medicine Reviews...
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Chapter 064. The Practice of Genetics in Clinical Medicine (Part 1) pptx
... role in educating patients about the indications, benefits, risks, and limitations of genetic testing in the management of Chapter 064. The Practice of Genetics in Clinical Medicine (Part 1) ... (Part 1) Harrison's Internal Medicine > Chapter 64. The Practice of Genetics in Clinical Medicine Implications of Molecular Genetics for Internal Medicine The field of medical genetics ... classified, enhancing our understanding of pathophysiology, providing practical information concerning drug metabolism and therapeutic responses, and allowing for individualized screening and health...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) ppt
... Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 67. Applications of Stem Cell Biology in Clinical Medicine ... Applications of Stem Cell Biology in Clinical Medicine: Introduction Organ damage and the resultant inflammatory responses initiate a series of repair processes, including stem cell proliferation, ... largely lacking. The quantity of cells from any single source can also be limiting. Organ-specific multipotent stem cells are already somewhat specialized and may be easier to induce into desired...
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