... lost in the lineage of the phylum Nematoda and in that of the order Rod-entia in mammals: Nox5 is absent in the nematodeCa. elegans and the rodents mouse and rat (Fig. 3).On the other hand, Nox2, ... including the Opi-sthokonta, the Amoebozoa, the Plantae, the Excavata, the Rhizaria, and the Chromalveolata (the Hetero-konta plus the Alveolata): animals and fungi belong to the Opisthokonta; the ... toprovide the axial and distal ligands for binding to the irons of two nonidentical hemes, thereby placing oneheme towards the cytoplasmic face and the othertowards the outer face (Fig. 1B). As the...