... TYLOSINTylosinisamacrolideantibioticwithactivityagainstgram-positiveandcertaingram-negative bacteria, including Staphylococcus, Listeria, Legionella, and Entero-coccus.Ithaslittleactivityagainstgram-negativeentericbacteriasuchasE. ... label).Tylosinwaslistedinthetoptenmostfrequentlydetectedantibioticsinsurfacewaterfrom1999to2000(Kolpinetal.,2002).Boxalletal.(2003)identiedtylo-sinasakeypharmaceuticalofinterestintheenvironment.Severalstudieshaveshownthatthisantibioticmayhaveanafnityforclayparticlesandorganicmatterinsoil,aswellastheorganiccomponentsofmanure,whichcouldaffectitsabilitytodegrade(RabølleandSpliid,2000;Kolzetal.,2005).Sorptiontosoilandmanurecomponents ... Kilpper-Balz, 19 87; Schaechter, 2000). Both organ-ismsarepotentiallypathogenicandcandevelopresistancetoantibioticsandhavethepotentialtotransferresistancegenestootherbacteria(Wegeneretal.,1999;Ochmanetal.,2000).Thesebacteriaarealsousedasfecalindicatorspeciesforwaterqual-ity...