... Hellenic Research Foundation. Journal compilation ª 2010 FEBS 3017ABCDE – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – Fig. 2. Sp1 binds to the p73 P1 ... alternativesplicing in the 3¢-end (leading to the formation of a, b,c, d, e, f and g isoforms) [ 8–1 2]; (b) the use of anextrinsic promoter (P1) and an alternative, intrinsicpromoter (P2) in the 5¢-end ... between the primary structure of TAp73a,TAp73b, and TAp73c. Alternative splicing results in the loss of the Pro-rich domain and in the truncation of the Glu ⁄ Pro-rich domain,which contains a...