VIRAL GENE THERAPY pot

... expression from lentiviral vectors. J Gene Med 10(1):21-32. 1 Retroviral Vectors in Gene Therapy: Mechanism of Integration, Successes in Gene Therapy Trials, Emerging Problems and Potential Solutions ... reviews the biology of HSV-1, and clinical trails and VIRAL GENE THERAPY Edited by Ke Xu Production of Retroviral and Lentiviral Gene Therapy Vectors: Challeng...

Ngày tải lên: 28/06/2014, 05:20

... the major gene therapy applications. Nevertheless, the plasmatic secretion peak of transgenic protein may be deleterious in many gene therapy applications including Epo gene therapy. Epo gene transfer ... Central Page 1 of 6 (page number not for citation purposes) Genetic Vaccines and Therapy Open Access Research Careful adjustment of Epo non -viral gene therapy for β-thal...

Ngày tải lên: 14/08/2014, 19:22

... vehicles for gene transfer: 1) Viral vectors for gene transduction (e.g., retroviral, adenoviral, adeno-associated viral and lentiviral vectors), and 2) Non -viral vectors for gene transfection ... Nucleic acids research, 31(15), e81. Non -Viral Gene Therapy 20 gene therapy for cystic fibrosis requires only partial gene correction. Gene therapy, 3(9), pp. 79...

Ngày tải lên: 27/06/2014, 18:20

... mammalian cells. Nature 1985, 313:812-815. 22. Calos MP: The potential of extra chromosomal replicating vectors for gene therapy. Trends Genet 1996, 12:463-466. 23. Kelleher ZT, Fu H, Livanos E, ... the long-term transgene (shRNA) expression vector was evaluated with the view of establishing highly effective therapeutic agents that can be further developed for HCV gene therapy applicat...

Ngày tải lên: 12/08/2014, 04:20

... introduction of genes using viral vectors or for the resistance to oncolytic gene therapy. We believe that this finding can be of cru- cial interest for the fie ld of c ancer vaccines and gene therapy ... purpose of gene therapy and adenoviruses are commonly used gene- delivery vectors due to the efficiency of their in vivo gene transfer [7]. Since 1993, about 300 clinical tri...

Ngày tải lên: 18/06/2014, 16:20

... E2b genes and the use of homologous (rat) BMP genes do not improve the osteogenic potential of direct BMP adenovirus vector gene therapy, the results of this study indicate that BMP gene therapy ... animals. 1. INTRODUCTION Gene therapy provides a novel method to repair damaged bone by using bone morphogenetic protein (BMP). BMP gene vectors can be divided into DNA, viral,...

Ngày tải lên: 31/10/2012, 17:08

... to human germline gene therapy. 2. Criteria for Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have ... important advances in gene transfer technology. K K e e y y w w o o r r d d s s gene targeting; gene therapy; genetic modification; pronuclear microinjection; sperm-medi...

Ngày tải lên: 03/11/2012, 10:01

... rapidly to background level by day 7 (figure 1a). When Gene Therapy - Tools and Potential Applications38 Gene types trasnferred in gene therapy clinical trials Adhesion molecule Antigen Antisense Cell ... intracellular de‐ livery, will lead to the design of better adapted non -viral vectors for gene therapy applica‐ Gene Therapy - Tools and Potential Applications20 vivo”, h...

Ngày tải lên: 17/03/2014, 21:20