TARGETS IN GENE THERAPY pptx
TARGETS IN GENE THERAPY pptx
... polylysine (K) or a polyarginine (R) tails, based on the Contents Preface IX Part 1 Target Strategy in Gene Therapy 1 Chapter 1 Choosing Targets for Gene Therapy 3 Karina J. ... chronic pseudomonas aeruginosa infections, and dornase alfa use. J Pediatr 153 (6):752-7. Part 1 Target Strategy in Gene Therapy Choosing Targets for Gene Therapy 9 Gene therapy of human β-thalassemia ... protein-DNA or protein-RNA interactions, examples for protein-protein interactions also exist. One example is Ikaros, a transcription factor participating in gene silencing and activation in...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... its receptor, trig-gering receptor kinase activity and signaling pathwaysinvolving the binding of ezrin to ezrin–radixin–moesinproteins, and thus actin cytoskeleton binding and Rasactivation. ... proteinsexist in three states with respect to HA binding: non-binding; nonbinding unless activated by physiologicalstimuli; and constitutively binding [17–19]. HA inducessignaling when it binds ... short cytoplasmic tailof CD44 binds to ankyrin and ezrin–radixin–moesinproteins, providing a link to the cytoskeleton, as wellas to merlin, which abrogates this binding. However,the multiple cellular...
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Báo cáo khoa học: Piecing together the structure of retroviral integrase, an important target in AIDS therapy pptx
... two-domain IN constructs, namely NTD–CCD and CCD–CTD, are being used as starting points for buildingmodels of the complete HIV-1 IN protein and IN DNA complexes [44]. These structures will beinformative, ... the IN domains are connected by flexiblelinkers allowing significant interdomain variability, anda three-domain model may not reflect the actual con-formation(s) of the intact protein alone or in ... implicate certain positivelycharged or hydrophobic residues in IN–DNAinteractions. Such residues identified in HIV-1 IN include His114, Tyr143, and Lys159 [85]. The DNA-binding CTD contains less...
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vectors in gene therapy
... promotor, resulting in tat-independent transcription. The self-inactivating vector was constructed by deleting133 bp in the U3 region of the 3¢ LTR including the TATA box and the binding sitesfor ... deletingretroviral genes and adding gene( s) of interest. Vectors can be produced in pack-aging cell lines that express packaging genes. The major advantage of retroviralvectors is the precise integration ... summarized in Table 4.4. Initially, packag-ing cell lines simply deleted the packaging sequence from a single packaging gene plasmid that contained all four genes and both LTRs. These lines occasionally...
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Báo cáo sinh học: " The state of the art of adeno-associated virus-based vectors in gene therapy" ppt
... ofexpressing foreign genes in mammalian cells [8,9], in theearly 1980s, AAV2 vectors have rapidly gained popularity in gene therapy applications, due to some of their distin-guishing biological ... overcome, rAAV-based gene transfer vectors still rep-resent one of the most promising gene therapy systemsand gain increasing popularity. In a search for "AAV gene therapy& quot;, 1,016 ... promising and distinguishing fea-tures of AAV vectors.However, there are also a few drawbacks in using AAV vec-tors for gene therapy applications. (1) Their size limits theinsertion of gene...
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Báo cáo hóa học: " The state of the art of adeno-associated virus-based vectors in gene therapy" doc
... overcome, rAAV-based gene transfer vectors still rep-resent one of the most promising gene therapy systemsand gain increasing popularity. In a search for "AAV gene therapy& quot;, 1,016 ... and insertional oncogenesis mediated by the"random" insertion of retroviruses into cellular DNA [48].Presently, other virus vectors have been gaining an impor-tant place in gene therapy ... isolation, as well asmethods for gene transfer and expression in in vitro stud-ies. As this vector system was used with increasing in gene delivery protocols, the interest in the complexities of AAVbiology...
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báo cáo hóa học:" Hypertriglyceridemia in Antiretroviral Therapy" pptx
... accelerated clinical trial of acombination of stavudine/lamivudine/nevirapine in thetreatment of people living with HIV-AIDS in Nigeria atthe University of Benin teaching hospital, one of the des-ignated ... monitoring of triglyceride andother indices of lipid profile in individuals on HAART,with a view to instituting therapy as early as possible whenvalues are found deranged, particularly in those ... choices. Curr Opin Infect Dis 2003, 16:19-23. Abstract4. Fontas E, van Leth F, Sabin CA, et al.: Lipid profiles in HIV-infectedpatients receiving combination antiretroviral therapy: aredifferent...
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NON-VIRAL GENE THERAPY pptx
... defective host gene remains unaltered. In general, the gene therapy recipient cells may be germline cells or somatic cells. Germline cells therapy involves modifying the genes in germ cells ... Non-Viral Gene Therapy Vectors Carrying Genomic Constructs 9 invasin, from the inv gene of Yersinia pseudotuberculosis, which binds to β1-integrins on mammalian cells leading to internalization, ... excluded (Harrington et al., 1997). This would not be a problem in ex vivo therapy where individual clones expressing the gene of interest from a HAC could be isolated, but in in vivo gene therapy, ...
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GENE THERAPY pptx
... and plays an importantrole in getting the virus inside a cell. Most of the remaining genes code18 Gene Therapy CoreFiberProtein VICapsidDNA genome Terminal protein PentonHexonStructure of ... terminal proteins. Several otherproteins, not shown, are stored in the core to initiate and maintain protection.The product of this gene is a protein called alpha-synuclein, which mayalso be involved ... developed, and investigators know thatmice have a gene that is similar to the human HD gene. Gene therapy trials for HD are in the planning stage. (See the gene therapy updates in chapter 8 for...
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Báo cáo y học: "Garden of therapeutic delights: new targets in rheumatic diseases" pptx
... protein kinasesMitogen-activated protein (MAP) kinases are stress-activatedserine/threonine kinases that include the p38, ERK (extra-cellular regulating kinase), and JNK (c-Jun-N-terminal kinase)(Figure ... these newkinase inhibitors.Lipid kinases: phosphatidylinositol 3-kinaseSeveral phosphatidylinositol 3-kinase (PI3K) inhibitors haveentered clinical trials in different fields, including oncology,cardiology, ... tyrosine kinases have intrinsic tyrosine phos-phorylation activity. The four Janus kinases (JAKs) are cyto-plasmic tyrosine kinases that pair in at least six differentcombinations to integrate...
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Từ khóa: and cterminal ring finger and pest domains homologous proteins include grail gene related to anergy in leukocytesthe product of the first gene in the nirbiogenesis operonwas recently identified in human peripheral blood monocytes treated with monocyte chemotactic protein 1 mcp1 and in human monocytederived macrophages stimulated with interleukin il1b these experiments revealed that the gene undergoes rapid and potentin searching for new targets for antimalarials we investigated the biosynthesis of hypusine present in eukaryotic initiation factor5a eif5a in plasmodium heremutations in the tumor suppressor breast cancer susceptibility gene 1 brca1Nghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ