TUMOR SUPPRESSOR GENES ppt

... Epithelium to Chapter 2 PTEN-Deficient Tumorigenesis 35 Chun-Ming Chen, Tsai-Ling Lu, Fang-Yi Su and Li-Ru You Identification of Tumor Suppressor Genes Chapter 3 via Cell Fusion and Chromosomal ... (13246-13256). 0006-2960. Tumor Suppressor Genes 36 Cre under the control of a ubiquitous promoter, ROSA26 (R26), to examine the susceptibility of all tissues to Pten-defici...

Ngày tải lên: 27/06/2014, 13:20

... never-smokers. 2. Oncogenes and Tumor Suppressor Genes (TSGs) Tumor growth is the result of the deregulation of intrinsic cell proliferation (cell di- vision). Genes known as protooncogenes code for ... adducts, and cause genetic changes, including mutations in oncogenes and tumor suppressor genes. There are major differences in the molecular pathogenesis of lung cancers arisi...

Ngày tải lên: 11/04/2014, 10:38

... advantage of yeast in order to gain new insights into tumor suppressor genes. Studies of true yeast homologs for human tumor suppressor genes, such as DNA repair enzymes, have not been included; ... Studies of the Wilms Tumor Suppressor Protein NMR spectroscopy has been used to study the structural changes resulting from post- transcriptional modification of the Wilms tumor s...

Ngày tải lên: 11/04/2014, 10:38

... to adjunct tumor classification, but also for clinical outcome prognosis. The general character of the assay used (with predefined tumor suppressor genes not necessary specific to any tumor type) ... progressive age- dependent promoter methylation of tumor suppressor genes and possible role of IGSF4 gene in colorectal carcinogenesis of microsatellite instable tumors. Cancer In...

Ngày tải lên: 18/06/2014, 16:20

... it is, in our case, not yet clear whether the tumor suppressor acts on the expression of the quoted genes directly or indirectly. With respect to tumor cells, the case of the differentiation-dependent ... 2007) doi:10.1111/j.1742-4658.2007.05851.x Expression of the tumor suppressor p16 INK4a after stable transfection can restore the susceptibility of epithelial tumor cells to an...

Ngày tải lên: 16/03/2014, 10:20

... the two tested housekeep- ing genes and for Gal-3 (Fig. 2C, right). De novo Gal-1 gene transcription, by contrast, increased significantly in the presence of the tumor suppressor (not shown). Thus, the ... Ludwig-Maximilians-Universita ¨ tMu ¨ nchen, Germany Introduction The tumor suppressor p16 INK4a , a frequent target for deletion mutations underlying carcinogenesis, is known as a...

Ngày tải lên: 29/03/2014, 21:20

... that RIZ1 might possess dual functions during tumor progression, acting as a tumor suppressor to induce apoptosis in the early stages and a tumor promoter to induce me- tastasis in late stages. ... hepatoma and suppression of he- patoma tumorigenicity by RIZ1. Int J Cancer 1999; 83: 541-6. 2. Jiang GL, Huang S. The yin-yang of PR-domain family genes in tumorigenesis. Histol His...

Ngày tải lên: 25/10/2012, 11:15

... between oncogenes and tumor suppressor is upset, favoring growth and survival of the tumor cell. One of the most important cellular barriers to cancer de- velopment is the retinoblastoma tumor suppressor ... normal cells into tumors. 3.1 The Discovery of pRB Thepathofdiscoveryfortheprototypictumorsuppressor,RB, has been repeated many times with the identification of human tumor sup...

Ngày tải lên: 25/10/2013, 21:20

... NF-jB target genes mentioned in an NF-jB review paper [25]. These genes were matched to human ensembl gene entries, resulting in 81 NF-jB seed genes. Joining those genes with available genes in the expression ... 435 genes were matched to ensembl genes. Those matched genes were used for further analysis and the seed-distribution-dis- tance method. For the gene ontology analysis,...

Ngày tải lên: 18/02/2014, 18:20