... CD8+cells, which express very high levels ofthe transcription factor eomesodermin, whose owntranscription is suppressed by ITK [35,51]. Anotherimportant transcriptional regulator is promyelocyticleukemia ... permissive for missense, butnot for nonsense, changes, as there are no reportedXLA patients with an R1 3 or R2 88 substitution, butplenty with stop codons [21]. Conversely, for otherarginine ... very stable and shorter proteinin COS7 and 293T cells. This shorter isoform, whichcan also be phosphorylated, is generated as a result ofalternative translation initiation. BTK–SYK also pro-duces...