MEDICINAL CHEMISTRY AND DRUG DESIGN   pot

... age spots and sites of actinic damage which can give rise to esthetic problems (Briganti, 2003; Curto, 1999). Hyperpigmentation usually becomes a big problem as people age because darker spots ... test hypotheses leading to the characterization of proteins of unknown function (Marcotte et al., 1999a, Marcotte 2000, Enright and Ouzounis 2001). Marcotte et al., (1999) found 6,809 potentially ... are reported to have potent anti-tyrosinase activity with almost 20-fold stronger than kojic acid. However, the inhibitory activity of kojic acid is not sufficiently potent or unstable for...

... unchanged, confirming one more time the great potentiality of fullerene.1.7 Drug DeliveryFullerene was also studied as a possible drug delivery system. The hypothesis of C60 as drug vector has been ... antibody responses in vivo, thus demonstrating the potential use of peptide–CNT conjugates for their application in vaccine delivery.2.4.2 Immunopotentiation by Cytosine-Phosphodiester-Guanine-Containing ... necessary to stop the anaphylaxis process are 400–300,000 times lower than the toxic values, this potential antiallergic compound would have a very good thera-peutic index (Ryan et al., 2007).Recently,...

... to the electrostatic potentialsurface calculated by ab initio calculations [31]. The AMBER* force field also usescharges derived from fitting to molecular electrostatic potentials. In contrast, ... results of a molecular mechanics (MM)calculation are highly dependent on the functional forms of the potential energyfunctions of the force field and of the quality of their parameterization. Thus ... Searching 151Jens Sadowski, Christof H. Schwab, and Johann Gasteiger8. Molecular Electrostatic Potentials 213Peter Politzer and Jane S. Murray9. Nonbonded Interactions 235Steve ScheinerviiThe...

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