alternatives to routine drug design and synthesis

... biodistribution and selective localization of the nanovector and its cytotoxic and/ or imaging agent Although the first type of molecules used to enhance the selective localization and delivery of nanovectors ... been my mentors and collaborators, as well as many other researchers from academia and industry Special thanks are due to the postdoctoral associates and graduate students in my laboratory at Northeastern ... approach to lead optimization, metabolism, and toxicity screening from that of small-molecule drugs Factors such as stability, immunogenicity, and species specificity had to be considered and tested...

Ngày tải lên: 04/06/2014, 14:30

... are viable and healthy [32], and inhibitors that are specific for PARP-1 are relatively non-toxic and not directly damage DNA, PARP-1 inhibitors might be both safe and effective for BRCA1/2-associated ... inhibition, there is evidence to suggest that PARP inhibitors may be useful in treating tumors in combination with cytotoxic drugs by increasing the sensitivity of the tumors to these agents Indeed, ... that by sensitizing tumor cells to cytotoxic agents one might be able to give a lower dose and maintain the same relative efficacy while at the same time reducing the toxic side effects Figure A...

Ngày tải lên: 31/10/2012, 16:57

... indicated the low dark toxicity and good biocompatibility In Vitro Photodynamic Efficacy Likewise, the MTT assay was performed to examine the phototoxicity of PHPP-SMNPs to SW480 colon carcinoma ... Biosafety Assessment and Photodynamic Activity Assay Intracellular Uptake As an essential tool in material science and biology, fluorescence microscopy demonstrates the ability to monitor the precise ... from 399 to 409 nm (c) Spectrum (d) indicated absorptions of SMNPs and HCl at 240, 314, and 364 nm, demonstrating that the 240, 314, and 364 nm peak of the spectrum (e) attributed to SMNPs and HCl...

Ngày tải lên: 22/06/2014, 01:20

... Management what it wants):  On-demand and scheduled reports with support for customisation  XML:  WAFs are expected to provide basic support for XML parsing and validation  Full XML support ... to independently audit traffic, and go back in time OWASP AppSec Europe 2006 Monitoring Requirements  Centralisation  Transaction data storage  Control over which transactions are logged and ... completely separate product OWASP AppSec Europe 2006 Other Things To Consider (2)  Extensibility:  Is it possible to add custom functionality to the firewall?  Is the source code available? (But not...

Ngày tải lên: 08/07/2013, 01:27

... need to seek out others with whom to work and collaborate seemed to stand out as an important characteristic of managers When asked, for example, to write imaginative stories in response to a ... both he and his subordinate would learn to validate the distinction between the authority to be preserved and the issues to be debated The ability to confront is also the ability to tolerate ... self-absorption and the inability to pay attention to the ordinary tasks at hand The only sure way an individual can interrupt reverielike preoccupation and self-absorption is to form a deep attachment to...

Ngày tải lên: 24/10/2013, 07:15

... “Chú làm vườn”) John is in his car now He is driving to work (Bây John xe anh Anh lái xe làm) Tom isn’t playing football this season (Mùa Tom không chơi bóng đá) (Hai người bạn gặp nói chuyện) ... từ thời gian tương lai “- What are you doing tomorrow evening?” “I’m going to the theatre” ("Bạn làm vào tối mai?” “Tôi xem hát”) Ann is buying a car tomorrow (Ngày mai Ann mua xe hơi) Groupwork: ... queue lie tie – queueing – lying – tying a Affirmative Mr Charlie is teaching History in the class They are talking to each other a Affirmative S be V-ing … I am / ’m You are / ’re She is / ’s...

Ngày tải lên: 31/10/2013, 09:11

Ngày tải lên: 01/11/2013, 12:20

... aren't satisfied, I'll go back to their homes and reclean their ducts as well." Jeff understands how to create a lifetime customer and a book of referrals out of a lost customer Since ducts are usually ... "You are the only customer who called to complain since we started using the new system at the beginning of this week I'm going to call all of the other customers and alert them to the problem If ... said to himself: "Why should I go out of my way to make this customer satisfied? They won't be a repeat customer anyway for years, if ever." But Jeff understands the power of both positive, and...

Ngày tải lên: 20/12/2013, 18:15

... xấu xí nhỏ bé phải không? - Không đâu, chúng không xấu xí nhỏ bé - Chúng đẹp to lớn phải không? - Đúng thế, chúng đẹp to lớn - Chúng phải không? - Không đâu, chúng chúng ta, chúng bạn Bước 6: Chỉ ... Trees vẽ hồng vẽ hoa cúc Roses Daisies vẽ hai ba người bác sĩ vẽ hai ba người y tá phải không? Doctors Nurses vẽ hai ba đội vẽ hai ba cảnh sát Armymen Policemen vẽ hai ba chó vẽ hai ba mèo Dogs ... chỗ trống câu sau: (Dùng từ: Flowers, trees, roses, daisies, dogs, cats, horses, buffaloes, doctors, nurses, armymen, policemen Mỗi từ dùng lần đặt từ "yes", "no" chỗ cần thiết) - Are we ...

Ngày tải lên: 21/01/2014, 15:20

... Transit peptide of Toc75 A J Baldwin and K Inoue Fig The biogenesis of pea Toc75 The precursor, intermediate, and mature forms of Toc75 are indicated as prToc75, iToc75, and mToc75 with the numbers ... supernatant to those in the membrane fraction appeared to be consistent among different reaction times within a single precursor (e.g., for AGA, compare lanes 19 and 20, 23 and 24, 27 and 28, and 31 and ... and GAG were prepared using sets of primers corresponding to nucleotide numbers 256–293 and 268–299 of psToc75, respectively, and pET-psToc75 as a template A plasmid encoding the AGG mutant and...

Ngày tải lên: 19/02/2014, 07:20

... afford to pay as a lump sum and/ or in monthly payments Be completely honest about your circumstances They’ll then put together a proposal to show to your creditors; you’ll be asked to sign this and ... is to send the proposal to your creditors who are asked to vote on it at a creditors’ meeting If 75% of your creditors ‘by value’ vote for the IVA to go ahead, it becomes binding on all creditors, ... loans, credit and store cards, catalogue debts and student loans You can also include tax or VAT owed to HM Revenue and Customs, though it may be given priority However, mortgages and other loans...

Ngày tải lên: 06/03/2014, 04:21

... Hoffman and Winston [47] The gene for eEF2 was amplified by PCR using primers eEF2F and eEF2R (supplementary Table S1) The 2.5 kb PCR-product was introduced into the TOPO vector pYES2.1 and the ... is regulated by the mitogen-activated protein (MAP) kinase and mTOR-signalling pathways [17] These signalling pathways activate the eEF2 kinase in response to mitogens and other stimuli that ... sequencing and by growing on the selective media, SC-Ura-Leu and SC-Leu-His GB1 cells transformed with empty pCBG1202 vector and the same vector containing wild-type eEF2 were used as negative and positive...

Ngày tải lên: 07/03/2014, 05:20

... the steps to be taken to achieve the transition from one state to another, or the steps to be taken to prohibit a transition THE BUSINESS RULES CONCEPTUAL MODEL To express the concepts and structure ... business were to define a new organization type (such as ‘GROUP’) between SECTION and DEPARTMENT, a new entity (and its corresponding table) would have to be added to the model, and the relationships ... is formal and specific, it is typically described in a general and informal fashion, and it often remains for the employees to translate it into meaningful specific statements of what to Yet, even...

Ngày tải lên: 15/03/2014, 21:20

Ngày tải lên: 18/03/2014, 11:20

... (Figure 1B and Table 1) Time course of anti-CCP antibodies Certain drugs that are commonly used to treat TB, such as INH and RIF, are known to be associated with drug- induced lupus and the production ... during apoptosis (13), and protein citrullination is a process associated with various inflammatory conditions regardless of the diagnosis (14), suggesting that inflammatory tissue and apoptotic cells ... antibodies or to the differences between epitopes expressed on solid-phase peptides bound to the plastic surface (considered partially denatured) and epitopes expressed on inhibitors in liquid...

Ngày tải lên: 22/03/2014, 18:20

... operators (MTOs) And for a while, they partnered up exclusively with dominant MTOs (Western Union, Money Gram) Today, savings banks have developed business cooperation with new and promising MTOs ... Postbank Kenya and Safaricom (a mobile phone operator) to offer mobile wallet service 22   Conclusion and recommendations Overall, the microfinance sector is continuing to expand despite tremendous ... a requirement of the Financial Sector Charter, which requires banks to make banking more accessible to the nation and, specifically, to increase banking reach to all communities The collaboration...

Ngày tải lên: 22/03/2014, 21:20

... (5¢TGGAGTCATCACCTGGCTTCC-3¢), and AP1 and SSI (5¢-CTGCCCACTGCATCAGGAAGC-3¢) Amplified products were cloned into a pCR 3.1 vector and transformed TOP10F¢ competent cells (Invitrogen, Breda, the Netherlands) DNA was ... (B and C) Autoradiography was performed for h (A) or days (B and C) The positions of the probes used are given in Fig The sizes of the bands are indicated The correspondence between the bands and ... (20 lg) of total RNA from each fraction were hybridized to a probe derived from exon 3; autoradiography was performed for days (T) Total RNA from prostate tissue The bands corresponding to cloned...

Ngày tải lên: 23/03/2014, 20:22

... Suzuki, and M Okumura 2004 Automatically collecting, monitoring, and mining Japanese weblogs In Proc 13th International World Wide Web Conf., pages 320–321 J.G Shanahan, Y Qu, and J Wiebe, editors ... (1) the full set of blog posts, referred to as the standard corpus, and (2) a corpus associated with the peaking interval, referred to as the sample corpus To compare word frequencies across the ... observed frequency of a term, Ni its total frequency, and Ei = (Ni · i Oi )/ i Ni its expected frequency in corpus i (where i takes values and for the standard and sample corpus, respectively) Then,...

Ngày tải lên: 24/03/2014, 03:20

... perform successfully? To get an objective perspective, ask your mentors Are you a great front man for the business? Are you able to tell a great story to investors and potential customers, but maybe ... a linesman trying to test the ‘tip’ and ‘ring’ signals on top of a telephone pole and that he didn’t have enough hands to all the functions required with separate speaking and listening devices ... that question is to examine the two sides to the recipe: You and The Business The “YOU” Factor: Health & Wellness You are priority number one, and you’ll need to stay in-shape to be successful...

Ngày tải lên: 24/03/2014, 05:22