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Báo cáo hóa học: " New Insights into the RLS Algorithm" pdf

Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

... proteins were sequenced. Of these, 10clones were found to encode the LC2 and LC1 sub-units. Others were found to encode other variants of the C-lectin-like venom proteins. The amino acidsequences ... 3944–3958 ª 2008 The Authors Journal compilation ª 2008 FEBS 3945 the corresponding D ion. Third, the 0,4A ion wouldinclude the 6-arm substituents, but not the extra Glc-NAc residue, if the latter ... the latter bisects the b-Man residue at the C4 position. Finally, an H ion would be formedthrough concerted loss of the substituents on the 6-arm and the bisecting GlcNAc. The identification of...
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Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc

Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc

... concentration, the rate of their passive diffusionthrough the plasma membrane and then the kineticparameters characteristic of their P-gp-mediated efflux.Our data show that the efficiencies of the P-gp-mediatedefflux ... the measurementof the rate of passive diffusion of the dye through the plasma membrane. This cannot be done by the simplemeasurement of the increase of the fluorescence signal(Fcyto) of the ... ratio of the drugbound to the drug free in the cytosol, which subsequentlyallows the determination of the real number of moleculesthat penetrate per second into one cell and therefore the true...
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báo cáo hóa học:

báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

... Finally in 1996 these micropar-ticles were recognized for their central role in antigen pres-entation with the work of Graça Raposo and Hans Geuzeof Utrecht University in the Netherlands, who ... cellcross-priming through the expression of HLA/peptidecomplexes [6]. Based on these and following observationsabout the role of exosomes in antigen presentation, the exacerbated production of these vesicles ... scientistresponsible for the studies on the immunosuppressivefunctions of tumor exosomes. PF was responsible foreditorial reviewing, scientist responsible for the studies on the induction of myeloid-derived...
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báo cáo hóa học:

báo cáo hóa học:" New insights into HIV-1-primary skin disorders" pot

... about the pathogenesis of these disorderssuggest that not only the decline in CD4+T cell counts[6], but also the shift into a Th2 cytokine profile [7], the molecular mimicry [8] and the over-expression ... by S. aureus [9]. Thesesuperantigens penetrate the skin and bind to Langerhanscells, thereby stimulating the release of IL-4 and IL-5,which further enhance the production of the allergen-specific ... erythematosus [117]. The cause of this mutation is due to the insertion of anendogenous retrovirus (early transposon class) into intron 14 of the Tetrat ricopeptide repeat domain7 gene. Further...
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Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx

Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx

... perturbations in the vicinity of the introducedmutation, with the overall fold conserved. The data presented here represent the first biophysi-cal characterizations of the KH domains of dFXRP. The structure ... FMRP function as the primary cause of the syndrome.In spite of its key importance, the effect of the I304N mutation on the structure and function ofFMRP is still unclear, and there have been ... on either the structural or functional consequences of the muta-tion.Because of the limitations in working with humans,Fragile X studies have expanded to other organisms.In vertebrates there...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

... maintainedtogether in either the test set or the working set. Although the data could be processed up to 2.5 A˚, there were somepractical problems in using the full dataset in the refine-ment – the ... in the orientation of the P3 moiety is further influenced by the different orienta-tion pattern of the individual P2 Leu residues. In erva-tamin-A, the P3 moiety of both the molecules of the asymmetric ... along the extended backbone ofresidues 65–64 and is partly exposed to the solvent(Fig. 2B). On the other hand, the P3 moiety of E-64 ineach of the of the two ervatamin-C molecules in the asymmetric...
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Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

... while the remaining subunits of the bc1complex are encoded in the nucleus, synthesized by cytosolicpolysomes, and then imported into mitochondria, therebyreaching their final location in the ... known about the function of the seven supernumerary subunits. To gain fur-ther insight into the function of the supernumerary subunitsin the assembly process, we have examined the subunitcomposition ... to the subunits of the yeast bc1complex indicated on the left side of the blots.1212 V. Zara et al. (Eur. J. Biochem. 271) Ó FEBS 2004Further insights into the assembly of the yeast cytochromebc1complex...
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Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx

Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx

... clarify whether these enzymes do indeed fulfiltheir predicted function, and how the properties of the enzymes differ from those of the homologous enzymesfrom O. formigenes. Although the crystal ... atompairs). The locations of the cofactor ThDP and the activator ADP are clearly defined in the electron densitymap. In contrast, electron density of the S-acetylpantetheine moiety of the inhibitor ... density wasfound for the S-acetyl pantetheine part of acetyl CoA,and consequently the model for the inhibitor remainsincomplete. The nitrogen atom of the amino group of the adenosine ring of...
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Báo cáo khoa học: New insights into evolution of crustacean hyperglycaemic hormone in decapods – first characterization in Anomura pdf

Báo cáo khoa học: New insights into evolution of crustacean hyperglycaemic hormone in decapods – first characterization in Anomura pdf

... between the CPRP and the mature hormone sequence, the posi-tion of the six cysteyl residues in the sequence, the sizeof the putative mature peptide (72 amino acid resi-dues), and presence of the ... revealed the existence of two distinct groups of neurons: the major-ity of them were stained only by the anti-CHH serum,and therefore probably represent the CHH secretorycells, whereas other neurons ... from the X-organsof P. bernhardus and G. strigosa. All the structural fea-tures of the CHHs (type I peptides) are present in the deduced amino acid sequences: the presence of aCPRP, the di-basic...
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báo cáo hóa học:

báo cáo hóa học:" New views on the hypothesis of respiratory cancer risk from soluble nickel exposure; and reconsideration of this risk''''s historical sources in nickel refineries" potx

... the KNR refinery, an unlikely finding that signals the presence of misclassification problems. In retrospect, the Pedersen et al. [1] study was the first human health studyto raise the hypothesis ... evidence standard[63] to examine the support for the soluble nickel cancerhypothesis; and have presented new findings and new analyses of existing findings of the human health and tox-icological ... includingarsenic, as the most probable cause of the respiratory can-cer risk observed in KNR's electrolysis department; andtheir absence in the same environment at PCNR as the likely reason for the normal...
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