... altering bind-ing properties of aminoglycosides such as paromomycin,neomycin, gentamicin, and kanamycin at the A-site of 12S rRNA [14]. Thus, the administration of aminoglyco-side s can induce or ... subjects (58 males and 40 females) had a his-tory of exposure to aminoglycosides including gentami-cin, streptomycin and kanamycin, accounting for 22.3%cases of hearing loss in this cohort. These ... screening of 12SrRNA gene in a cohort of 440 hearing-impaired HanChinese pediatric subjects from two otology clinics atNingbo and Wenzhou, Zhejiang Province, China. Muta-tional analysis of 12S...