báo cáo hóa học:" The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike protein" docx

... Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike protein Yee-Joo Tan* Address: Institute of Molecular and Cell ... postulate a functional role for the evolution of the SARS-CoV 3a protein. The SARS-CoV S protein lacks the YxxΦ motif but it can bi...

Ngày tải lên: 20/06/2014, 04:20

... the premature release of unassembled viral RNA. It may also enhance virus packaging as it appears that the assembly of coronavirus occurs intracellularly, probably in the intermediate compartments ... postulate a functional role for the evolution of the SARS-CoV 3a protein. The SARS-CoV S protein lacks the YxxΦ motif but it can bind to the 3a protein whi...

Ngày tải lên: 18/06/2014, 22:20

... Institute of Molecular Medicine, National Tsing Hua University, Hsin-Chu, Taiwan An outbreak of severe acute respiratory syndrome (SARS) occurred primarily in Asia in 2003. The causa- tive agent of SARS ... 11507–11512. Supplementary material The following supplementary material is available online: Fig. S1. The SARS N protein is phosphorylated by SRPK1 but not by Clk1 a...

Ngày tải lên: 23/03/2014, 07:20

... 0.046, was also associated with severe anaemia. In this analysis, AZT was similarly not associated with early severe anae- mia in both men and women. Outcomes of patients with baseline anaemia Among ... had early severe anaemia (Hb ≤8 g/dl). Thirty (27.5%) of the patients with early severe anaemia had b aseline severe anaemia and these had unreso lved baseline severe anae- m...

Ngày tải lên: 20/06/2014, 08:20

... in tumour invasion, metastases associated with melanomas, as well as with cancer of the breast, colon, lung, pancreas, and prostate [7,8]. Although the exact role of PAR1 in tumour cell invasion is ... first appearance. In all cases diagnosis of metastases was con- firmed by X-ray and/or CT-scan for lung metastasis, gamma gram for bone metastases, ultrasonic detection or CT-scan...

Ngày tải lên: 18/06/2014, 15:20

... behalf of International Malignant Melanoma Collaborative G: Interferon -a as adjuvant therapy for melanoma: an individual patient data meta-analysis of randomised trials. J Clin Oncol (Meeting Abstracts) ... postoperative adjuvant IFN -a 2b therapy and 5 (23%) received preo- perative neoadjuvant IFN -a 2b therapy. Two of the stage IV patients had lung metastases and 1 had distant...

Ngày tải lên: 18/06/2014, 16:20

... and Pain Research Center Amsterdam, Waalstraat 25-31, 1078 BR Amsterdam, The Netherlands Full list of author information is available at the end of the article Vermeulen et al. Journal of Translational ... worsened in the second test. This implies an increase of lactate, the product of anaerobic glycolysis, and a decrease of the mitochondrial ATP production in the...

Ngày tải lên: 18/06/2014, 16:20

... report the number of falls in the past year. Data Analysis Prior to data analyses the gait variability data were exam- ined for normality. The gait variability data were relatively normally distributed ... the association with future falls [2,3]. In actuality, the participants' gait was measured after the person had fallen. Having experienced a fall, the partici- pant...

Ngày tải lên: 19/06/2014, 10:20

... The vertical oscillation of the head has been found to oscillate at the same frequency as the trunk [46]. We have also observed that average SF measured by GPS was identical to average SF measured ... research area. In the field of wind engineering and industrial aerody- namics, Tamura and colleagues [45] recently demon- strated that GPS (RTK mode) was capable of an accurate...

Ngày tải lên: 19/06/2014, 10:20

... GraphPad Software, San Diego CA, http://www.graphpad.com ). GraphPad Prism was also used to construct Kaplan-Meier mortality curves and assess for significance. Statistical significance was assumed ... bio- chemical and histological measurements of microglial activation. This increase in microglial activation in the IL1raKO mice is also associated with an increase in the degree of syn...

Ngày tải lên: 19/06/2014, 22:20