... Asia in 2003. The causa-tive agent of SARS is a coronavirus-related virus [1,2]. The genome sequence ofthe SARS virus is only mod-erately similar to that of other species of coronaviruses[3] ... phosphorylation.Effect of RS motif phosphorylation onoligomerization ofthe N proteinTo better understand the effect of RS motif phosphor-ylation on the biological function ofthe N protein, weFig. 3. The translation ... Journal compilation ª 2008 FEBS 4157 Phosphorylation ofthe arginine/serine dipeptide-rich motif of thesevereacuterespiratorysyndrome coronavirusnucleocapsid protein modulates its multimerization,translation...
... tail ofthe spike protein of most coronaviruses, mediates the intracellular retention of the spike protein. This motif is missing from the spike protein ofthesevereacute respiratory syndrome- coronavirus ... could confer certainadvantages during the replication ofthesevereacuterespiratory syndrome- coronavirus.Background The recent severeacuterespiratorysyndrome (SARS) epi-demic, which affected ... will indicate that thesevere acute respiratory syndrome- coronavirus modulates the surface expression ofthe spike protein via adifferent mechanism from other coronaviruses. The interaction between...
... tail ofthe spike protein of most coronaviruses, mediates the intracellular retention of the spike protein. This motif is missing from the spike protein ofthesevereacute respiratory syndrome- coronavirus ... could confer certainadvantages during the replication ofthesevereacuterespiratory syndrome- coronavirus.Background The recent severeacuterespiratorysyndrome (SARS) epi-demic, which affected ... will indicate that thesevere acute respiratory syndrome- coronavirus modulates the surface expression ofthe spike protein via adifferent mechanism from other coronaviruses. The interaction between...
... determinants of spread of causal agent ofsevereacute respiratory syndrome in Hong Kong. Lancet, 2003. 361:1761-6. 68. Pan S.F., et al. Cardiac arrest in severeacuterespiratory syndrome: analysis of ... Effectiveness of non-invasive positive pressure ventilation in the treatment of acuterespiratory failure in severeacuterespiratory syndrome. Chest (in press) 44. Liu X.Q., et al. Management of critical ... Pattern of Disease in Patients with Severe AcuteRespiratory Syndrome. Am J Roentgenol, 2004. 182:493-498. 64. Lew T.W., et al. Acuterespiratorysyndrome in critically-ill patients with severe acute...
... bindingwith the small molecule involves a larger molecularinterface in the case ofthe former helicase. Further-more, the absence ofthe S259 OH group in the mutated viral enzyme prevents the formation ... Similarly, the structures of heli-case S ⁄ L and L ⁄ F mutants were obtained, and the atomiccoordinates ofthe lowest energy structures ofthe wild-typeform of SARS-CoV helicase are available from the ... interfere in the interaction ofthe enzyme with itsnatural substrates. The presence ofthe leucyl sidechain in the protein mutant appears to cause sterichindrance to bananin binding, leaving the traffic...
... presentation ofthe material in this publication do not imply the expression of any opinion whatsoever on the part ofthe World Health Organization concerning the legal status of any country, ... efforts in the next few years will focus on responding to the needs ofthe ten countries with the highest number of pregnant women with HIV. It is in these countries, where 75% ofthe need for ... 00080% The bar indicates the uncertainty range around the estimate. Percentage of pregnant women living with HIV receiving antiretrovirals to reduce the risk of mother-to-child transmission of...
... sequencing of a total of 6946 bp, which include the ata genes most likely implicatedin the biosynthesis of this moiety of A201A. Evidence for the functional identification of three of these genes ... it. Further sequencing ofthe atacluster could provide an insight into the biosyntheticpathway ofthe other moieties of A201A and provideprobes which may be useful to identify genes of the hygromycin ... identical tothose ofthe similar genes ofthe pur cluster. In Actinomyc-etes, this approach has led to the functional characterization of genes implicated in the biosynthesis of a variety of antibiotics...
... quality model to estimate the dispersion function, the accuracy ofthe estimated emissions will depend on the ability ofthe model to reproduce the dispersion ofthe pollutants. Until now, ... in the emission factors of VOCs for LDVs and HDVs. The emission factors calculated in this study are generally higher compared to the results ofthe other studies around the world. Only the ... observed at this period ofthe day. From 2 pm to 6 pm, the wind direction is oblique to the street axis and the wind speed is higher than in the morning. At these hours ofthe day, tracer ...
... absolutely ignorant ofthe meaning ofthe words Soul, Spirit, Intelligence: how, then, can we logically reason from the presence ofthe one to the existence ofthe other? I reject, then, even when ... further delay, that the hopes ofthe friends of association were groundless. Thus, then, the gentlemen ofthe Academy disavow, in their session-chamber, their announcements from the tripod! There ... seeking for the meaning and content ofthe idea of God; and that the tradesmen ofthe university will impute to me the impiety of demonstrating the non-value of their philosophical products, when...
... the death of holder thereof and before the maturity ofthe certificate, or before the certificate having reached maturity has been discharged, the nominee shall on the death ofthe holder of ... may be, appoint the person to receive payment of the amount due on the account in the event of death ofthe depositor or depositors, as the case may be, during the minority ofthe nominee. ... (iii) the period from the date of opening the account to the date of death ofthe depositor or surviving depositor, as the case may be, is not less than two years. (iv) The age ofthe depositor...
... itoescanserveasmechanicalvectors of PRRSVandcantransport thevirus atleast2.4kmfromaninfectedfarm. The site of retentiono f thevirus in the flyis the GItractand the rate of viraldecayovertimeisinfluencedbyquantityingestedandenvironmentaltemperature.Inordertopreventspread of PRRSVviainsects the followingstepsarer ... Once the evacuationperiodisover, the interiordoorcanbeopenedallowingpersonnel/pigstoenterinside the facility orleave the facilityvia the externaldoor.Aview ofthe baffleinletin the chamberNote: The doubledoorsystem ... isrecommendedtoenhancedetection of peracuteinfections. Samplescollectedlatein the isolationperiodcanalsobetestedby ELISAfor the presence of PRRSVantibodies.o With the advent ofthe bloodswabtechnique,AIcenterscanproactivelymonitor...
... you, the hypotheses of time, space, motion, thought, and the laws of thought. Then you may verify the hypothesis of pauperism, the hypothesis of inequality of conditions, the hypothesis of universal ... association, the hypothesis of happiness, the hypotheses of monarchy and republicanism, the hypothesis of Providence! . . . . A complete criticism of God and humanity. I point to the programme ofthe ... WHAT, THEN, IS THE TRUTH IN RELATION TO US, AND WHAT IS THE CHARACTER OF CERTAINTY? As if the Academy had said to us: You shall verify the hypothesis of your existence, the hypothesis of the...
... by tetramer staining inthree ofthe four patients, although the frequencies of tetramer-positive cells were rather low in 2 of them as theydid not exceed 0.2% of CD8+ T cells which was muchlower ... protein either in the interferon-gamma ELISPOT assay or in the proliferationassay in five ofthe seven patients (figures 1 and 2). None of the 4 patients who remained negative in the anti-HCVELISA ... [26,31,32]. Nevertheless, for the manage-ment ofacute hepatitis C patients our study supports the concept to investigate the kinetic of HCV-viremia for 2–3weeks before an antivirial therapy is considered...
... governmental activities in the statement of activitiesare different because:Governmental funds report capital outlays as expenditures. However, in the statement of activities the cost of those assets ... compensation liability reported in the statement of activities do notrequire the use of current financial resources and therefore are not reported as expenditures in the governmental funds until ... Accrual and other adjustments 2,338,525 12,655,143 Excess (deficiency) of revenues over expenditures – GAAP basis $ (22,934,844) $ 12,186,380 The following reconciles the excess of revenues...
... by tetramer staining inthree ofthe four patients, although the frequencies of tetramer-positive cells were rather low in 2 of them as theydid not exceed 0.2% of CD8+ T cells which was muchlower ... [26,31,32]. Nevertheless, for the manage-ment ofacute hepatitis C patients our study supports the concept to investigate the kinetic of HCV-viremia for 2–3weeks before an antivirial therapy is considered ... clearance in the absence of anti-HCV. HCV-RNA levels, ALT levels and T cell responses are shown. Coloured bars show the sum of SI values ofthe proliferation assay and the sum of specific interferon-gamma...